scholarly journals In Vitro Evaluation of Cerebrospinal Fluid Velocity Measurement Agreement, Reliability, and Reproducibility in Type I Chiari Malformation Using 2D Phase Contrast Magnetic Resonance Imaging and 4D Flow Imaging

2020 ◽  
Author(s):  
Gwendolyn Williams ◽  
Suraj Thyagaraj ◽  
Audrey Fu ◽  
John Oshinski ◽  
Daniel Giese ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Chiari Malformation ◽  
Phase Contrast ◽  
Resonance Imaging ◽  
4D Flow ◽  
Csf Dynamics ◽  
Contrast Magnetic Resonance ◽  
Repeatability And Reproducibility ◽  
Flow Techniques

Abstract Background Phase contrast magnetic resonance imaging, PC MRI, is a valuable tool allowing for non-invasive quantification of CSF dynamics, but has lacked adoption in clinical practice for Chiari malformation diagnostics. To improve these diagnostic practices, a better understanding of PC MRI based measurement agreement, repeatability, and reproducibility of CSF dynamics is needed. Methods An anatomically realistic in vitro subject specific model of a Chiari malformation patient was scanned three times at five different scanning centers using 2D PC MRI and 4D Flow techniques to quantify intra-scanner repeatability, inter-scanner reproducibility, and agreement between imaging modalities. Peak systolic CSF velocities were measured at nine axial planes using 2D PC MRI, which were then compared to 4D Flow peak systolic velocity measurements extracted at those exact axial positions along the model. Results Comparison of measurement results showed good overall agreement of CSF velocity detection between 2D PC MRI and 4D Flow (p = 0.86), fair intra-scanner repeatability (confidence intervals ± 2 cm/s), and poor inter-scanner reproducibility. On average, 4D Flow measurements had a larger variability than 2D PC MRI measurements (standard deviations 1.83 and 1.04 cm/s, respectively). Conclusion Agreement, repeatability, and reproducibility of 2D PC MRI and 4D Flow detection of peak CSF velocities was quantified using a patient-specific in vitro model of Chiari malformation. In combination, the greatest factor leading to measurement inconsistency was determined to be a lack of reproducibility between different MRI centers. Overall, these findings may help lead to better understanding for application of 2D PC MRI and 4D Flow techniques as diagnostic tools for CSF dynamics quantification in Chiari malformation and related diseases.

scholarly journals In Vitro Evaluation of Cerebrospinal Fluid Velocity Measurement Agreement, Reliability, and Reproducibility in Type I Chiari Malformation Using 2D Phase Contrast Magnetic Resonance Imaging and 4D Flow Imaging

2021 ◽  
Author(s):  
Gwendolyn Williams ◽  
Suraj Thyagaraj ◽  
Audrey Fu ◽  
John Oshinski ◽  
Daniel Giese ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Chiari Malformation ◽  
Phase Contrast ◽  
Resonance Imaging ◽  
4D Flow ◽  
Csf Dynamics ◽  
Contrast Magnetic Resonance ◽  
Repeatability And Reproducibility ◽  
Flow Techniques

Abstract Background: Phase contrast magnetic resonance imaging, PC MRI, is a valuable tool allowing for non-invasive quantification of CSF dynamics, but has lacked adoption in clinical practice for Chiari malformation diagnostics. To improve these diagnostic practices, a better understanding of PC MRI based measurement agreement, repeatability, and reproducibility of CSF dynamics is needed.Methods: An anatomically realistic in vitro subject specific model of a Chiari malformation patient was scanned three times at five different scanning centers using 2D PC MRI and 4D Flow techniques to quantify intra-scanner repeatability, inter-scanner reproducibility, and agreement between imaging modalities. Peak systolic CSF velocities were measured at nine axial planes using 2D PC MRI, which were then compared to 4D Flow peak systolic velocity measurements extracted at those exact axial positions along the model. Results: Comparison of measurement results showed good overall agreement of CSF velocity detection between 2D PC MRI and 4D Flow (p = 0.86), fair intra-scanner repeatability (confidence intervals ±1.5 cm/s), and poor inter-scanner reproducibility. On average, 4D Flow measurements had a larger variability than 2D PC MRI measurements (standard deviations 1.83 and 1.04 cm/s, respectively). Conclusion: Agreement, repeatability, and reproducibility of 2D PC MRI and 4D Flow detection of peak CSF velocities was quantified using a patient-specific in vitro model of Chiari malformation. In combination, the greatest factor leading to measurement inconsistency was determined to be a lack of reproducibility between different MRI centers. Overall, these findings may help lead to better understanding for application of 2D PC MRI and 4D Flow techniques as diagnostic tools for CSF dynamics quantification in Chiari malformation and related diseases.

scholarly journals In vitro evaluation of cerebrospinal fluid velocity measurement in type I Chiari malformation: repeatability, reproducibility, and agreement using 2D phase contrast and 4D flow MRI

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Gwendolyn Williams ◽  
Suraj Thyagaraj ◽  
Audrey Fu ◽  
John Oshinski ◽  
Daniel Giese ◽  
...  
Keyword(s):  
Chiari Malformation ◽  
Phase Contrast ◽  
Patient Specific ◽  
Type I ◽  
4D Flow ◽  
Csf Dynamics ◽  
Flow Measurements ◽  
Repeatability And Reproducibility ◽  
Flow Techniques

Abstract Background Phase contrast magnetic resonance imaging, PC MRI, is a valuable tool allowing for non-invasive quantification of CSF dynamics, but has lacked adoption in clinical practice for Chiari malformation diagnostics. To improve these diagnostic practices, a better understanding of PC MRI based measurement agreement, repeatability, and reproducibility of CSF dynamics is needed. Methods An anatomically realistic in vitro subject specific model of a Chiari malformation patient was scanned three times at five different scanning centers using 2D PC MRI and 4D Flow techniques to quantify intra-scanner repeatability, inter-scanner reproducibility, and agreement between imaging modalities. Peak systolic CSF velocities were measured at nine axial planes using 2D PC MRI, which were then compared to 4D Flow peak systolic velocity measurements extracted at those exact axial positions along the model. Results Comparison of measurement results showed good overall agreement of CSF velocity detection between 2D PC MRI and 4D Flow (p = 0.86), fair intra-scanner repeatability (confidence intervals ± 1.5 cm/s), and poor inter-scanner reproducibility. On average, 4D Flow measurements had a larger variability than 2D PC MRI measurements (standard deviations 1.83 and 1.04 cm/s, respectively). Conclusion Agreement, repeatability, and reproducibility of 2D PC MRI and 4D Flow detection of peak CSF velocities was quantified using a patient-specific in vitro model of Chiari malformation. In combination, the greatest factor leading to measurement inconsistency was determined to be a lack of reproducibility between different MRI centers. Overall, these findings may help lead to better understanding for application of 2D PC MRI and 4D Flow techniques as diagnostic tools for CSF dynamics quantification in Chiari malformation and related diseases.

scholarly journals Numerical simulation of time-resolved 3D phase-contrast magnetic resonance imaging

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248816
Author(s):  
Thomas Puiseux ◽  
Anou Sewonu ◽  
Ramiro Moreno ◽  
Simon Mendez ◽  
Franck Nicoud
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Phase Contrast ◽  
Navier Stokes ◽  
Resonance Imaging ◽  
4D Flow Mri ◽  
4D Flow ◽  
Time Resolved ◽  
Contrast Magnetic Resonance ◽  
Flow Mri

A numerical approach is presented to efficiently simulate time-resolved 3D phase-contrast Magnetic resonance Imaging (or 4D Flow MRI) acquisitions under realistic flow conditions. The Navier-Stokes and Bloch equations are simultaneously solved with an Eulerian-Lagrangian formalism. A semi-analytic solution for the Bloch equations as well as a periodic particle seeding strategy are developed to reduce the computational cost. The velocity reconstruction pipeline is first validated by considering a Poiseuille flow configuration. The 4D Flow MRI simulation procedure is then applied to the flow within an in vitro flow phantom typical of the cardiovascular system. The simulated MR velocity images compare favorably to both the flow computed by solving the Navier-Stokes equations and experimental 4D Flow MRI measurements. A practical application is finally presented in which the MRI simulation framework is used to identify the origins of the MRI measurement errors.

In vitro characterization of aortic flow using numerical simulation, phase-contrast magnetic resonance imaging, and particle tracking images

2008 ◽  
Vol 222 (12) ◽  
pp. 2455-2462 ◽  
Author(s):  
A-S Yang ◽  
C-Y Wen ◽  
L-Y Tseng
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Thoracic Aorta ◽  
Phase Contrast ◽  
Aortic Flow ◽  
Resonance Imaging ◽  
Vitro Experiment ◽  
In Vitro Experiment ◽  
Contrast Magnetic Resonance

Thoracic aorta and its three branches at the aortic arch are the inceptive zones of the aortic dissection and atherosclerosis. Owing to the complicated aortic flow, the geneses of these highly fatal diseases are the abnormal pressures and shear stresses acting upon the vascular intima. Hence, it is important to determine the distributions of wall shear stress (WSS) and wall pressure to predict these aortic disorders. In this study, the phase-contrast magnetic resonance imaging (PC-MRI) method was used to obtain the true geometry of a normal human thoracic aorta, which can be converted into a transparent thoracic aorta model by the rapid prototyping technique. The thoracic aorta model is then used in the in vitro experiment and computations. Numerical calculations were performed using the computational fluid dynamic software ACE+® to determine the flow characteristics of the three-dimensional, steady, incompressible, and Newtonian fluid in the thoracic aorta model. The boundary conditions at the inlet and the outlet of the aortic flow were specified from the measured data in the in vitro experiment. The predictions were in reasonable agreement with the PC-MRI-measured velocity profiles in the sagittal plane of the thoracic aorta model. The predictions suggest the preferential development of the early aortic dissection and atherosclerosis in the areas of either maxima or minima of WSS and wall pressure.

Estimating the Hemodynamic Impact of Interventional Treatments of Aneurysms

Neurosurgery ◽  
2006 ◽  
Vol 59 (2) ◽  
pp. E429-E430 ◽  
Author(s):  
Gabriel Acevedo-Bolton ◽  
Liang-Der Jou ◽  
Bradley P. Dispensa ◽  
Michael T. Lawton ◽  
Randall T. Higashida ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Magnetic Resonance ◽  
Phase Contrast ◽  
Resonance Imaging ◽  
Contrast Magnetic Resonance Imaging ◽  
Phase Contrast Magnetic Resonance ◽  
Contrast Magnetic Resonance

Abstract OBJECTIVE: The goal of this study was to use phase-contrast magnetic resonance imaging and computational fluid dynamics to estimate the hemodynamic outcome that might result from different interventional options for treating a patient with a giant fusiform aneurysm. METHODS: We followed a group of patients with giant intracranial aneurysms who have no clear surgical options. One patient demonstrated dramatic aneurysm growth and was selected for further analysis. The aneurysm geometry and input and output flow conditions were measured with contrast-enhanced magnetic resonance angiography and phase-contrast magnetic resonance imaging. The data was imported into a computational fluid dynamics program and the velocity fields and wall shear stress distributions were calculated for the presenting physiological condition and for cases in which the opposing vertebral arteries were either occluded or opened. These models were validated with in vitro flow experiments using a geometrically exact silicone flow phantom. RESULTS: Simulation indicated that altering the flow ratio in the two vertebrals would deflect the main blood jet into the aneurysm belly, and that this would likely reduce the extent of the region of low wall shear stress in the growth zone. CONCLUSIONS: Computational fluid dynamics flow simulations in a complex patient-specific aneurysm geometry were validated by in vivo and in vitro phase-contrast magnetic resonance imaging, and were shown to be useful in modeling the likely hemodynamic impact of interventional treatment of the aneurysm.

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