scholarly journals Central Retinal Vascular Trunk Deviation in Unilateral Open-angle Glaucoma

2020 ◽  
Author(s):  
Kyoung Min Lee ◽  
Martha Kim ◽  
Sohee Oh ◽  
Seok Hwan Kim
Keyword(s):  
Axial Length ◽  
Open Angle Glaucoma ◽  
Estimating Equation ◽  
Lamina Cribrosa ◽  
Glaucomatous Optic Neuropathy ◽  
Open Angle ◽  
Susceptibility Factor ◽  
Systemic Factors ◽  
Parapapillary Atrophy ◽  
Generalized Linear Mixed Effects

Abstract Patients with unilateral open-angle glaucoma (OAG) have suffered glaucomatous optic neuropathy in one eye only despite shared systemic factors between two eyes. It suggests a locoregional susceptibility factor associated with glaucoma development. In this study, we measured the distance of the central retinal vascular trunk from the Bruch’s membrane opening (BMO) center relative to that of the BMO margin: the shift index, since it can be used as a surrogate of lamina cribrosa (LC) shift caused by different growth between retinal and scleral layers during eyeball expansion. The shift index was compared between OAG and fellow control eyes within individuals (129 OAG patients). Although OAG eyes also had higher baseline IOP, a larger β-zone parapapillary atrophy area, a larger shift index was the only risk factor of OAG diagnosis in a generalized linear mixed-effects model. Further, a generalized estimating equation regression model revealed that the shift index was larger in the OAG eyes than in the control eyes for all ranges of axial length, while it was the smallest for the axial length of 23.7 mm. Thus, a larger shift index and LC shift may act as a locoregional susceptibility factor for unilateral OAG eyes.

scholarly journals Central retinal vascular trunk deviation in unilateral normal-tension glaucoma

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0254889
Author(s):  
Ho-Kyung Choung ◽  
Martha Kim ◽  
Sohee Oh ◽  
Kyoung Min Lee ◽  
Seok Hwan Kim
Keyword(s):  
Axial Length ◽  
Normal Tension Glaucoma ◽  
Estimating Equation ◽  
Lamina Cribrosa ◽  
Angular Deviation ◽  
Linear Mixed Effects ◽  
Parapapillary Atrophy ◽  
Optical Coherence Tomography Imaging ◽  
Generalized Linear Mixed Effects

Purpose To investigate whether the position of the central retinal vascular trunk (CRVT), as a surrogate of lamina cribrosa (LC) offset, was associated with the presence of glaucoma in normal-tension glaucoma (NTG) patients. Methods The position of the CRVT was measured as the deviation from the center of the Bruch’s membrane opening (BMO), as delineated by spectral-domain optical coherence tomography imaging. The offset index was calculated as the distance of the CRVT from the BMO center relative to that of the BMO margin. The angular deviation of CRVT was measured with the horizontal nasal midline as 0° and the superior location as a positive value. The offset index and angular deviation were compared between glaucoma and fellow control eyes within individuals. Results NTG eyes had higher baseline intraocular pressure (P = 0.001), a larger β-zone parapapillary atrophy area (P = 0.013), and a larger offset index (P<0.001). In a generalized linear mixed-effects model, larger offset index was the only risk factor of NTG diagnosis (OR = 31.625, P<0.001). A generalized estimating equation regression model revealed that the offset index was larger in the NTG eyes than in the control eyes for all ranges of axial length, while it was the smallest for the axial length of 23.4 mm (all P<0.001). Conclusions The offset index was larger in the unilateral NTG eyes, which fact is suggestive of the potential role of LC/BMO offset as a loco-regional susceptibility factor.

scholarly journals Comparison of Ocular Biometry between Primary Open Angle Glaucoma Patients and Normal subjects

2021 ◽  
Vol 13 (2) ◽  
pp. 62-68
Author(s):  
Nisha Manandhar ◽  
Chandni Pradhan ◽  
Purushottam Joshi ◽  
Prabha Subedi ◽  
Pranav Shrestha
Keyword(s):  
Anterior Chamber ◽  
Axial Length ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Anterior Chamber Depth ◽  
Control Group ◽  
Open Angle ◽  
K Value ◽  
The Difference ◽  
Glaucoma Group

Introduction: Glaucoma is one of the major causes of irreversible blindness. In Nepal, the most common type of Glaucoma seen is Primary Open Angle Glaucoma. There are many risk factors associated with Primary Open Angle Glaucoma. The main objective of the study was to compare ocular biometric parameters in patients diagnosed with Primary Open Angle Glaucoma and age matched controls. Material and methods: This is a hospital based cross sectional study done at Mechi Eye Hospital. The study included 137 cases of Primary Open Angle Glaucoma and 75 normal individuals as control.  Axial length (AL), anterior chamber depth (ACD), Keratometry ‘K’ value and Central Corneal Thickness (CCT) were measured. Mann – Whitney U test was used for statistical analysis. Results: Mean age in Primary Open Angle Glaucoma group was (55.25 ± 10.16 years) and in the control group was (60.96 ± 10.91 years). Axial length  in the Primary Open Angle Glaucoma group (23.16 ±1.19 mm) was deeper as compared to the control group (22.69 ±0.89 mm), the difference was statistically significant (p<0.001). Anterior chamber depth (ACD) was statistically deeper in the Primary Open Angle Glaucoma group (3.05 ±0.51 mm) as compared to the control group (2.86 ±0.46 mm), (p<0.01). Central corneal thickness (CCT) was thinner in the Primary Open Angle Glaucoma group (519.5 ±36.25 um) as compared to the control group (525.40 ±37.77 um) but the difference was not found to be statistically significant (p<0.19). K value in Primary Open Angle Glaucoma (7.54 ±0.41mm) was higher than age-matched controls (7.58 ± 0.33mm) but the difference was not statistically significant (p<0.79). Conclusion: Patients with Primary Open Angle Glaucoma had longer Axial length (AL) and deeper Anterior chamber depth (ACD) as compared to normal individuals.

scholarly journals Comparison of Lamina Cribrosa Curvature in Pseudoexfoliation and Primary Open-Angle Glaucoma

2021 ◽  
Vol 223 ◽  
pp. 1-8
Author(s):  
Hun Jae Won ◽  
Kyung Rim Sung ◽  
Joong Won Shin ◽  
Youn Hye Jo ◽  
Min Kyung Song
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Lamina Cribrosa ◽  
Open Angle

3D Reconstruction of Scleral Shell Using Three Dimensional Active Contours

2012 ◽  
Author(s):  
Avinash Ayyalasomayajula ◽  
Jonathan P. Vande Geest
Keyword(s):  
Intraocular Pressure ◽  
Dynamic Response ◽  
Primary Open Angle Glaucoma ◽  
Active Contours ◽  
Open Angle Glaucoma ◽  
Three Dimensional ◽  
Constitutive Models ◽  
Lamina Cribrosa ◽  
Open Angle ◽  
Scleral Shell

There is a general consensus that elevation in intraocular pressure (IOP), due to a reduced outflow of aqueous humor, is a major factor leading to primary open-angle glaucoma (POAG). Studies indicated that the damage of the optic nervehead (ONH), due to the biomechanical environment in and around the lamina cribrosa (LC), could be an important event leading to POAG [Morgan]. Since experimentally testing tissues of such small dimensions is difficult, many researchers resorted to computationally model the biomechincal environment inside the eye [Avatar, Kobayashi, Sigal, Uchio, Xu, Tandon]. It also gives the flexibility to parametrically study and isolate the effects of individual tissues on the IOP and LC. Many of these studies involve stress analysis on a hypothetical geometry (for e.g. spherical or axisymmetric hemisphere) using a variety of constitutive models (for e.g. elastic, biphasic etc) to study the static, and dynamic response of the IOP [Tandon, Sigal].

Albuminuria and Primary Open-Angle Glaucoma: the Singapore Chinese Eye Study (SCES)

2020 ◽  
pp. bjophthalmol-2020-315920 ◽  
Author(s):  
Zhi Wei Lim ◽  
Miao-Li Chee ◽  
Sahil Thakur ◽  
Xiaoling Fang ◽  
Zhi Da Soh ◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Smoking Status ◽  
Open Angle Glaucoma ◽  
Estimating Equation ◽  
Population Based ◽  
Urinary Albumin ◽  
Open Angle ◽  
Chinese Adults ◽  
Medication History ◽  
Singapore Chinese

AimsTo determine the association between albuminuria and primary open-angle glaucoma (POAG).MethodsParticipants of the Singapore Chinese Eye study were recruited and underwent standardised ocular and systemic examinations. Albuminuria was determined using urinary albumin-to-creatinine ratio (UACR, mg/g) based on random spot urinary albumin and creatinine measurements. POAG was defined using the International Society of Geographic and Epidemiological Ophthalmology classification. Multivariable logistic regression with generalised estimating equation model was used to evaluate the association between albuminuria and POAG, while accounting for correlation between eyes.ResultsA total of 3009 Chinese adults (5963 eyes), aged 40–80 years, were included in this study, of which, 52 subjects (75 eyes) had POAG. Higher UACR (per 50 mg/g increase) was independently associated with POAG (OR=1.04, 95% CI 1.01 to 1.07, p=0.003) following adjustment for age, gender, intraocular pressure, diabetes mellitus, hyperlipidaemia, hypertension, anti-hypertensive medication, history of cardiovascular disease, current smoking status, alcohol intake, body mass index and estimated glomerular filtration rate. Further stratification revealed that individuals with macroalbuminuria were 8.00 times likely to have POAG (95% CI 2.97 to 21.54, p<0.001), compared with those with normoalbuminuria. Microalbuminuria was not significantly associated with POAG (OR=0.49, 95% CI 0.19 to 1.29, p=0.150). The association between macroalbuminuria and POAG remained significant among individuals who were diabetic (OR=9.89, 95% CI 2.49 to 39.30, p=0.001) and hypertensive (OR=8.39, 95% CI 3.07 to 22.94, p<0.001).ConclusionIn this population-based study of Chinese adults, albuminuria was independently associated with POAG. Our findings provide further understanding on the pathogenesis of POAG and may potentially help to better identify individuals at risk of POAG.

Sign in / Sign up

Export Citation Format

Share Document