Inflammatory Pseudo Tumor-Like Follicular Dendritic Cell Sarcoma of the Liver with Hepatic Lymphoma History:A Case Report and Literature Review

Abstract Background:Inflammatory Pseudo Tumor (IPT)-like Follicular Dendritic Cell (FDC) Sarcoma of the liver is a very rare disease and occurs mostly in the lymph nodes. Till now, only 19 cases were reported in the English literature. However, the coexistence of IPT-like Sarcoma and Non-Hodgkin’s Lymphoma(NHL) in the same patient has never been reported.Case presentation:We reported a case of a 47-year-old male patient who had a history of Hepatitis B virus (HBV) infection and presented with right upper abdominal discomfort. Nineteen years ago, he underwent liver resection of segment VII for Hepatic Non-Hodgkin Lymphoma (B-cell lymphoma). Serum alpha fetoprotein (AFP) level was normal. However, Imaging studies revealed a well-circumscribed, solid mass in the right hepatic lobe and was diagnosed as (Hepatocellular Carcinoma) HCC or Hepatic Lymphoma preoperatively. Right hemi-hepatectomy was performed on this patient. Histological report showed features of a mixture of chronic inﬂammatory cells and variable amounts of spindle cells. Also, Immuno-Histo-Chemical (IHC) studies demonstrated that all the tumor cells showed strong nuclear in situ labeling for EBV-encoded small RNAs (EBER) and strongly positive stainings with CD21 and CD35. The patient is still disease free after a follow-up of 40 months. Conclusions:To our knowledge, this is the first report demonstrating Hepatic IPT-like FDC Sarcoma in a patient with Primary Hepatic Non-Hodgkin Lymphoma history. In regards to treatment, complete surgical resection should be performed and would acquire excellent long-term outcomes.

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Inflammatory Pseudo Tumor-Like Follicular Dendritic Cell Sarcoma of the Liver with Hepatic Lymphoma History: A Case Report and Literature Review

10.21203/rs.3.rs-144038/v1 ◽

2021 ◽

Author(s):

Jian Li ◽

Wenqiang Wang ◽

Dong Chen ◽

Wajeehullahi Akilu ◽

Zhiyong Huang ◽

...

Keyword(s):

Dendritic Cell ◽

Hodgkin Lymphoma ◽

English Literature ◽

B Cell Lymphoma ◽

Inflammatory Cells ◽

Follicular Dendritic Cell ◽

Non Hodgkin Lymphoma ◽

Dendritic Cell Sarcoma ◽

Follicular Dendritic ◽

Upper Abdominal

Abstract Background: Inflammatory Pseudo Tumor (IPT)-like Follicular Dendritic Cell (FDC) Sarcoma of the liver is a very rare disease and occurs mostly in the lymph nodes. Till now, only 19 cases were reported in the English literature. However, the coexistence of IPT-like Sarcoma and Non-Hodgkin’s Lymphoma(NHL) in the same patient has never been reported.Case presentation: We reported a case of a 47-year-old male patient who had a history of Hepatitis B virus (HBV) infection and presented with right upper abdominal discomfort. Nineteen years ago, he underwent liver resection of segment VII for Hepatic Non-Hodgkin Lymphoma (B-cell lymphoma). Serum alpha fetoprotein (AFP) level was normal. However, Imaging studies revealed a well-circumscribed, solid mass in the right hepatic lobe and was diagnosed as (Hepatocellular Carcinoma) HCC or Hepatic Lymphoma preoperatively. Right hemi-hepatectomy was performed on this patient. Histological report showed features of a mixture of chronic inﬂammatory cells and variable amounts of spindle cells. Also, Immuno-Histo-Chemical (IHC) studies demonstrated that all the tumor cells showed strong nuclear in situ labeling for EBV-encoded small RNAs (EBER) and strongly positive stainings with CD21 and CD35. The patient is still disease free after a follow-up of 40 months. Conclusions: To our knowledge, this is the first report demonstrating Hepatic IPT-like FDC Sarcoma in a patient with Primary Hepatic Non-Hodgkin Lymphoma history. In regards to treatment, complete surgical resection should be performed and would acquire excellent long-term outcomes.

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Inflammatory pseudotumor-like follicular dendritic cell sarcoma of the liver with hepatic lymphoma history: a case report and literature review

10.21203/rs.3.rs-84946/v1 ◽

2020 ◽

Author(s):

Erlei Zhang ◽

Wenqiang Wang ◽

Jian Li ◽

Dong Chen ◽

Zhiyong Huang

Keyword(s):

Dendritic Cell ◽

Hodgkin Lymphoma ◽

Surgical Resection ◽

English Literature ◽

B Cell Lymphoma ◽

Follicular Dendritic Cell ◽

Positive Staining ◽

Non Hodgkin Lymphoma ◽

Follicular Dendritic ◽

Disease Free

Abstract BackgroundInflammatory pseudotumor (IPT)-like follicular dendritic cell (FDC) sarcoma of the liver is very rare and mostly occurs in females. Up to now, 19 cases were reported in the English literature. Surgical resection remains the preferred method for the management of this kind of tumor. Case presentationWe reported a case of a 47-year-old male patient who had hepatitis B virus infection history and presented with up-abdominal discomfort. He underwent liver resection of segment VII for hepatic non-hodgkin lymphoma (B-cell lymphoma) 19 years ago. Serum alpha fetoprotein was normal. Imaging studies revealed a well-circumscribed, solid mass in the right hepatic lobe and was diagnosed as HCC or hepatic lymphoma. Right hemihepatectomy was performed and the patient was disease free after a follow-up of 20 months. Histological feature showed a mixture of chronic inﬂammatory cells and variable amounts of spindle cells. Immunohistochemical studies demonstrated that all the tumor cells showed strong nuclear in situ labeling for EBV-encoded small RNAs (EBER) and strongly positive staining with CD21 and CD35. A diagnosis of hepatic IPT-like FDC sarcoma was rendered. The coexistence of IPT-like sarcoma and non-Hodgkin’s lymphoma in same patient is extremely rare. He remains disease-free more than 40 months after surgical resection.ConclusionTo our knowledge, this is the first report to demonstrate hepatic IPT-like FDC sarcoma in a patient with primary hepatic non-hodgkin lymphoma history. Complete surgical resection should be pursued.

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Follicular Dendritic Cell Sarcoma of the Thyroid Gland in a Patient with Preexisting Hashimoto’s Thyroiditis: A Rare Case Report with a Literature Review

Case Reports in Oncology ◽

10.1159/000520485 ◽

2021 ◽

pp. 1698-1705

Author(s):

Seyed-ahmad Seyed-alagheband ◽

Mohammad-kazem Shahmoradi ◽

Omid-Ali Adeli ◽

Tahereh Shamsi ◽

Maryam Sohooli ◽

...

Keyword(s):

Dendritic Cell ◽

Thyroid Gland ◽

English Literature ◽

Radical Neck Dissection ◽

Cervical Lymphadenopathy ◽

Follicular Dendritic Cell ◽

Follicular Dendritic Cell Sarcoma ◽

Cell Sarcoma ◽

Dendritic Cell Sarcoma ◽

Follicular Dendritic

Thyroid follicular dendritic cell sarcoma (FDCS) is an extremely rare malignancy that originates from follicular dendritic cells of the thyroid germinal centers. To the best of our knowledge, there are only 4 reported cases of thyroid FDCS in the English literature. Herein, we present the fifth case of FDCS of the thyroid gland. A 63-year-old woman presented with a painless midline neck mass, enlarging for the last 4 months. Physical examination revealed a 6-cm nonmobile, firm, multinodular thyroid mass with palpable cervical lymphadenopathy. Due to high suspicion for thyroid malignancy, the patient underwent total thyroidectomy with bilateral modified radical neck dissection. Histologic evaluations revealed sheets of storiform eosinophilic tumoral cells with prominent nucleoli containing multinucleated giant cells, and subsequent immunohistochemistry showed immunoreactivity for CD4, CD21, CD35, CD45 (LCA), and CD68. The patient was started on 6 cycles of doxorubicin, ifosfamide, and radiotherapy. She has had monthly thyroid ultrasonography and contrast-enhanced thoracoabdominal CT scan every 3 months for detecting potential recurrence and/or metastasis screening. Fortunately, 8 months after the operation, the patient is alive without any signs of local or distant metastasis.

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Proliferation of non-Hodgkin-lymphoma lymphocytes in vitro is dependent upon follicular dendritic cell interactions

British Journal of Haematology ◽

10.1111/j.1365-2141.1992.tb06395.x ◽

1992 ◽

Vol 80 (1) ◽

pp. 21-26 ◽

Cited By ~ 35

Author(s):

Stephan Petrasch ◽

Marie Kosco ◽

Carmelo Perez-Alvarez ◽

JÃ¶rn Schmitz ◽

GÃ¼nter Brittinger

Keyword(s):

Dendritic Cell ◽

Hodgkin Lymphoma ◽

Follicular Dendritic Cell ◽

Cell Interactions ◽

Non Hodgkin Lymphoma ◽

Follicular Dendritic

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Follicular Dendritic Cell Sarcoma Presenting as a Submucosal Tumor of the Stomach

Archives of Pathology & Laboratory Medicine ◽

10.5858/2000-124-1693-fdcspa ◽

2000 ◽

Vol 124 (11) ◽

pp. 1693-1696

Author(s):

Jae-Ho Han ◽

Se-Hoon Kim ◽

Sung-Hun Noh ◽

Yong-Chan Lee ◽

Ho-Guen Kim ◽

...

Keyword(s):

Dendritic Cell ◽

Submucosal Tumor ◽

English Literature ◽

Follicular Dendritic Cell ◽

Epithelioid Cell ◽

Hollow Viscus ◽

Ultrastructural Studies ◽

Dendritic Cell Sarcoma ◽

Follicular Dendritic ◽

High Index Of Suspicion

Abstract Follicular dendritic cell (FDC) sarcomas, especially those of extranodal origin, are extremely rare, and this entity could easily be missed without a high index of suspicion. We report a case of FDC sarcoma presenting as a submucosal tumor of the stomach in a 45-year-old man. The mass was a spindle and epithelioid mesenchymal tumor with many individually scattered and perivascular aggregates of lymphocytes. Immunohistochemical and ultrastructural studies confirmed the diagnosis. Although more than 50 cases of this tumor have been documented in the English literature, to our knowledge the presentation of FDC sarcoma as a submucosal tumor of the stomach has never been recorded. This case highlights the occurrence of FDC sarcoma as a submucosal tumor of the gastrointestinal tract. We believe that FDC sarcoma should be included in the differential diagnosis of spindle or epithelioid cell tumors of the gastrointestinal hollow viscus to prevent this still underrecognized tumor from being overlooked.

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