scholarly journals Sjögren's Syndrome in Children: About 15 Cases in Guinea Conakry

2021 ◽  
Author(s):  
Kaba Condé ◽  
Carlos Othon Guelngar ◽  
Mamadou Ciré Barry ◽  
Hugues Ghislain Atakla ◽  
Awada Mohamed ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Rare Entity ◽  
Oral Ulceration ◽  
Male Predominance ◽  
Black Africa ◽  
African Context ◽  
Sjögren‘S Syndrome

Abstract Objectives- Sjögren's syndrome is difficult to diagnose in the African context. It is rarely reported in children in Black Africa. We report a series of 15 cases of Sjögren’s syndrome in order to clarify the particularities of this condition in children.Methods- This 2-year retrospective study focused on children under 16 years of age with a male predominance who were followed for AS in the rheumatology and pediatrics departments. Patient data were collected and analyzed using STATA/SE version 11.2 software. Anonymity and respect for ethical rules were the norm. There was no link between patients and researchers.Results- The average age of the patients was 11 years with extremes of 5 to 15 years. An anamnesis revealing dry mouth was found in more than half of the cases, i.e. in 10 (66.7%) patients. The clinical examination found oral ulceration and periodontitis in equal proportions, i.e. 6 (40%). The immunological assessment and the biopsy of the accessory salivary glands were used as diagnostic evidence in the 15 patients according to the American-European criteria of 2002.Conclusion- Sjögren's syndrome is a rare entity in pediatrics. It is difficult to diagnose in pediatrics and its severity is linked to the occurrence of visceral and lymphomatous late dry syndrome. Rapid diagnosis and the use of a synthetic antimalarial drug (Hydroxychloroquine) increases the hope of a cure.

scholarly journals Sjögren's Syndrome in Children: About 15 Cases in Guinea Conakry

2021 ◽  
Author(s):  
Kaba Condé ◽  
carlos othon Guelngar ◽  
Mamadou Ciré Barry ◽  
Hugues Ghislain Atakla ◽  
Awada Mohamed ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Rare Entity ◽  
Oral Ulceration ◽  
Male Predominance ◽  
Black Africa ◽  
African Context ◽  
Sjögren‘S Syndrome

Abstract Objectives- Sjögren's syndrome is difficult to diagnose in the African context. It is rarely reported in children in Black Africa. We report a series of 15 cases of Sjögren’s syndrome in order to clarify the particularities of this condition in children.Methods- This 2-year retrospective study focused on children under 16 years of age with a male predominance who were followed for AS in the rheumatology and pediatrics departments. Patient data were collected and analyzed using STATA/SE version 11.2 software. Anonymity and respect for ethical rules were the norm. There was no link between patients and researchers.Results- The average age of the patients was 11 years with extremes of 5 to 15 years. An anamnesis revealing dry mouth was found in more than half of the cases, i.e. in 10 (66.7%) patients. The clinical examination found oral ulceration and periodontitis in equal proportions, i.e. 6 (40%). The immunological assessment and the biopsy of the accessory salivary glands were used as diagnostic evidence in the 15 patients according to the American-European criteria of 2002.Conclusion- Sjögren's syndrome is a rare entity in pediatrics. It is difficult to diagnose in pediatrics and its severity is linked to the occurrence of visceral and lymphomatous late dry syndrome. Rapid diagnosis and the use of a synthetic antimalarial drug (Hydroxychloroquine) increases the hope of a cure.

The association of Raynaud’s phenomenon/syndrome with scleroderma and Sjögren’s syndrome – a meta-analysis

VASA ◽  
2008 ◽  
Vol 37 (Supplement 73) ◽  
pp. 26-32 ◽  
Author(s):  
Schlattmann ◽  
Höhne ◽  
Plümper ◽  
Heidrich
Keyword(s):  
Quantitative Analysis ◽  
Sjögren’S Syndrome ◽  
Mixture Model ◽  
Sjögren's Syndrome ◽  
Meta Analysis ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Raynaud’S Syndrome ◽  
Raynaud's Syndrome ◽  
Sjögren‘S Syndrome

Background: In order to analyze the prevalence of Raynaud’s syndrome in diseases such as scleroderma and Sjögren’s syndrom – a meta-analysis of published data was performed. Methods: The PubMed data base of the National Library of Medicine was used for studies dealing with Raynaud’s syndrome and scleroderma or Raynaud’s syndroem and Sjögren’s syndrom respectively. The studies found provided data sufficient to estimate the prevalence of Raynaud’s syndrome. The statistical analysis was based on methods for a fixed effects meta-analysis and finite mixture model for proportions. Results: For scleroderma a pooled prevalence of 80.9% and 95% CI (0.78, 0.83) was obtained. A mixture model analysis found four latent classes. We identified a class with a very low prevalence of 11%, weighted with 0.15. On the other hand there is a class with a very high prevalence of 96%. Analysing the association with Sjögren’s syndrome, the pooled analysis leads to a prevalence of Raynaud’s syndrome of 32%, 95% CI(26.7%, 37.7%). A mixture model finds a solution with two latent classes. Here, 38% of the studies show a prevalence of 18.8% whereas 62% observe a prevalence of 38.3%. Conclusion: There is strong variability of studies reporting the prevalence of Raynaud’s syndrome in patients suffering from scleroderma or Sjögren’s syndrome. The available data are insufficient to perform a proper quantitative analysis of the association of Raynaud’s phenomenon with scleroderma or Sjögren’s syndrome. Properly planned and reported epidemiological studies are needed in order to perform a thorough quantitative analysis of risk factors for Raynaud’s syndrome.

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