Association between dietary salt and plasma glucose, insulin and hemoglobin A1C levels among type 2 diabetes patients in Eastern China

Abstract Purpose: Type 2 diabetes (T2D) is one of the major public health concerns in China. Studies on the association between dietary salt intake and the glycaemia response of T2D are lacking in China. The aim was to investigate the association between the levels of dietary salt intake and the plasma glucose, insulin and hemoglobin A1c (HbA1c) in T2D patients.Methods: Patients with T2D, who accepted management and treatment by the National Standardized Metabolic Disease Management Center at Ningbo First Hospital from March 2018 to January 2020, were included in this study. Dietary salt was collected through a standardized food frequent questionnaire. Anthropometry, blood pressure and biomarkers were measured by well-trained endocrinology nurses. Generalized linear models (GLM) were used to examine the association.Results: A total of 1145 eligible T2D patients with the mean age of 51.4 years were included in the study. Fasting plasma glucose (FPG), 2h postprandial plasma glucose and 2h postprandial insulin, were significantly increased across dietary salt categories. Generalized linear models further showed that dietary salt >8g/d were positively associated with FPG and HbA1c.Conclusion: Higher daily salt intake was found to be associated with FPG and HbA1c in T2D patients. Lifestyle education and promotion on salt reduction should be provided to T2D patients.

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Association between dietary salt and plasma glucose, insulin and hemoglobin A1C levels among type 2 diabetes patients in Eastern China

10.21203/rs.3.rs-924532/v1 ◽

2021 ◽

Author(s):

Yi Lin ◽

Kaushik ◽

Xi Yang ◽

Jia-Lin Li ◽

Yan-Shu Chen ◽

...

Keyword(s):

Type 2 Diabetes ◽

Generalized Linear Models ◽

Plasma Glucose ◽

Hemoglobin A1c ◽

Linear Models ◽

Salt Intake ◽

Eastern China ◽

Dietary Salt ◽

Dietary Salt Intake

Abstract Purpose Type 2 diabetes (T2D) is one of the major public health concerns in China. Studies on the association between dietary salt intake and the glycaemia response of T2D are lacking in China. The aim was to investigate the association between the levels of dietary salt intake and the plasma glucose, insulin and hemoglobin A1c (HbA1c) in T2D patients. Methods Patients with T2D, who accepted management and treatment by the National Standardized Metabolic Disease Management Center at Ningbo First Hospital from March 2018 to January 2020, were included in this study. Dietary salt was collected through a standardized food frequent questionnaire. Anthropometry, blood pressure and biomarkers were measured by well-trained endocrinology nurses. Generalized linear models (GLM) were used to examine the association. Results A total of 1145 eligible T2D patients with the mean age of 51.4 years were included in the study. Fasting plasma glucose (FPG), 2h postprandial plasma glucose and 2h postprandial insulin, were significantly increased across dietary salt categories. Generalized linear models further showed that dietary salt > 8g/d were positively associated with FPG and HbA1c. Conclusion Higher daily salt intake was found to be associated with FPG and HbA1c in T2D patients. Lifestyle education and promotion on salt reduction should be provided to T2D patients.

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The Association Between Dietary Salt Intake and the Glycaemia Response Among Type 2 Diabetes Patients in Eastern China

10.21203/rs.3.rs-96005/v1 ◽

2020 ◽

Author(s):

Yi Lin ◽

Xi Yang ◽

Yan-Shu Chen ◽

Ye Zhou ◽

Li Li

Keyword(s):

Plasma Glucose ◽

Medical Information ◽

Linear Models ◽

Salt Intake ◽

Eastern China ◽

Density Lipoprotein ◽

Final Analysis ◽

Dietary Salt ◽

Dietary Salt Intake ◽

Postprandial Plasma Glucose

Abstract BackgroundType 2 diabetes (T2D) is one of public health concerns in China with a rapid increase in prevalence. The study on salt intake and risk of T2D is still lack in China.AimsTo investigate the association between dietary salt intake levels and the glycaemia response of T2D.MethodsA total of 1145 T2D patients, who accepted standardized management by the National Standardized Metabolic Disease Management Center at Ningbo First Hospital from March 2018 to January 2020, were selected in the final analysis. Demography, lifestyle and medical information were collected through questionnaires. Anthropometry, blood pressure and biomarkers were measured by well-trained endocrinology nurses. Generalized linear models (GLM) were used to examine the association.ResultsHigher prevalence of overweight and central obesity with larger BMI and waist circumference were found in higher salt categories 6-8g/d and ≥8g/d, compared to lower salt categories. Fasting plasma glucose (FPG), 2h postprandial plasma glucose, 2h postprandial insulin, total cholesterol, triglyceride and low-density lipoprotein cholesterol were significantly different across salt intake categories. GLM further shows that salt intake 6-8g/d and ≥8g/d were positively associated with FPG and salt intake 6-8g/d and ≥8g/ d was associated with HbA1c.ConclusionIncreasing salt intake is suggested to be associated with the glycaemia response at the fasting state in T2D patients. Hospital-based education is needed for improvement of awareness, attitude and action on restriction of salt consumption.

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