scholarly journals Association Between Dietary Salt and Plasma Glucose, Insulin and Hemoglobin A1c Levels Among Type 2 Diabetes Patients in Eastern China

2021 ◽  
Vol Volume 14 ◽  
pp. 4811-4818
Author(s):  
Yi Lin ◽  
Kaushik Chattopadhyay ◽  
Xi Yang ◽  
Jia-Lin Li ◽  
Yan-Shu Chen ◽  
...  

2021 ◽  
Author(s):  
Yi Lin ◽  
Kaushik ◽  
Xi Yang ◽  
Jia-Lin Li ◽  
Yan-Shu Chen ◽  
...  

Abstract Purpose Type 2 diabetes (T2D) is one of the major public health concerns in China. Studies on the association between dietary salt intake and the glycaemia response of T2D are lacking in China. The aim was to investigate the association between the levels of dietary salt intake and the plasma glucose, insulin and hemoglobin A1c (HbA1c) in T2D patients. Methods Patients with T2D, who accepted management and treatment by the National Standardized Metabolic Disease Management Center at Ningbo First Hospital from March 2018 to January 2020, were included in this study. Dietary salt was collected through a standardized food frequent questionnaire. Anthropometry, blood pressure and biomarkers were measured by well-trained endocrinology nurses. Generalized linear models (GLM) were used to examine the association. Results A total of 1145 eligible T2D patients with the mean age of 51.4 years were included in the study. Fasting plasma glucose (FPG), 2h postprandial plasma glucose and 2h postprandial insulin, were significantly increased across dietary salt categories. Generalized linear models further showed that dietary salt > 8g/d were positively associated with FPG and HbA1c. Conclusion Higher daily salt intake was found to be associated with FPG and HbA1c in T2D patients. Lifestyle education and promotion on salt reduction should be provided to T2D patients.



2021 ◽  
Author(s):  
Yi Lin ◽  
Kaushik Chattopadhyay ◽  
Xi Yang ◽  
Jia-Lin Li ◽  
Yan-Shu Chen ◽  
...  

Abstract Purpose: Type 2 diabetes (T2D) is one of the major public health concerns in China. Studies on the association between dietary salt intake and the glycaemia response of T2D are lacking in China. The aim was to investigate the association between the levels of dietary salt intake and the plasma glucose, insulin and hemoglobin A1c (HbA1c) in T2D patients.Methods: Patients with T2D, who accepted management and treatment by the National Standardized Metabolic Disease Management Center at Ningbo First Hospital from March 2018 to January 2020, were included in this study. Dietary salt was collected through a standardized food frequent questionnaire. Anthropometry, blood pressure and biomarkers were measured by well-trained endocrinology nurses. Generalized linear models (GLM) were used to examine the association.Results: A total of 1145 eligible T2D patients with the mean age of 51.4 years were included in the study. Fasting plasma glucose (FPG), 2h postprandial plasma glucose and 2h postprandial insulin, were significantly increased across dietary salt categories. Generalized linear models further showed that dietary salt >8g/d were positively associated with FPG and HbA1c.Conclusion: Higher daily salt intake was found to be associated with FPG and HbA1c in T2D patients. Lifestyle education and promotion on salt reduction should be provided to T2D patients.



2021 ◽  
Author(s):  
Yi Lin ◽  
Kaushik ◽  
Xi Yang ◽  
Jia-Lin Li ◽  
Yan-Shu Chen ◽  
...  

Abstract Purpose Type 2 diabetes (T2D) is one of the major public health concerns in China. Studies on the association between dietary salt intake and the glycaemia response of T2D are lacking in China. The aim was to investigate the association between the levels of dietary salt intake and the plasma glucose, insulin and hemoglobin A1c (HbA1c) in T2D patients. Methods Patients with T2D, who accepted management and treatment by the National Standardized Metabolic Disease Management Center at Ningbo First Hospital from March 2018 to January 2020, were included in this study. Dietary salt was collected through a standardized food frequent questionnaire. Anthropometry, blood pressure and biomarkers were measured by well-trained endocrinology nurses. Generalized linear models (GLM) were used to examine the association. Results A total of 1145 eligible T2D patients with the mean age of 51.4 years were included in the study. Fasting plasma glucose (FPG), 2h postprandial plasma glucose and 2h postprandial insulin, were significantly increased across dietary salt categories. Generalized linear models further showed that dietary salt > 8g/d were positively associated with FPG and HbA1c. Conclusion Higher daily salt intake was found to be associated with FPG and HbA1c in T2D patients. Lifestyle education and promotion on salt reduction should be provided to T2D patients.



2009 ◽  
Vol 94 (5) ◽  
pp. 1689-1694 ◽  
Author(s):  
William H. Herman ◽  
Kathleen M. Dungan ◽  
Bruce H. R. Wolffenbuttel ◽  
John B. Buse ◽  
Jessie L. Fahrbach ◽  
...  


2012 ◽  
Vol 6 (3) ◽  
pp. 721-722
Author(s):  
B. Shivananda Nayak ◽  
Kameel Mungrue ◽  
Shawn Seepersad ◽  
Justin Sookram ◽  
Shalina Singh ◽  
...  




2021 ◽  
pp. 1-9
Author(s):  
Tobias Bomholt ◽  
Marianne Rix ◽  
Thomas Almdal ◽  
Filip K. Knop ◽  
Susanne Rosthøj ◽  
...  

<b><i>Introduction:</i></b> The accuracy of hemoglobin A1c (HbA1c) as a glycemic marker in patients with type 2 diabetes (T2D) receiving hemodialysis (HD) remains unknown. To assess accuracy, we compared HbA1c and fructosamine levels with interstitial glucose measured by continuous glucose monitoring (CGM) in patients with T2D receiving HD. <b><i>Methods:</i></b> Thirty patients in the HD group and 36 patients in the control group (T2D and an estimated glomerular filtration rate &#x3e;60 mL/min/1.73 m<sup>2</sup>) completed the study period of 17 weeks. CGM (Ipro2<sup>®</sup>, Medtronic) was performed 5 times for periods of up to 7 days (with 4-week intervals) during a 16-week period. HbA1c (mmol/mol), the estimated mean plasma glucose from HbA1c (eMPGA1c [mmol/L]) and fructosamine (μmol/L) was measured at week 17 and compared with mean sensor glucose levels from CGM. <b><i>Findings:</i></b> In the HD group, mean sensor glucose was 1.4 mmol/L (95% confidence interval [CI]: 1.0–1.8) higher than the eMPGA1c, whereas the difference for controls was 0.1 mmol/L (95% CI: −0.1–[0.4]; <i>p</i> &#x3c; 0.001). Adjusted for mean sensor glucose, HbA1c was lower in the HD group (−7.3 mmol/mol, 95% CI: −10.0–[−4.7]) than in the control group (<i>p</i> &#x3c; 0.001), with no difference detected for fructosamine (<i>p</i> = 0.64). <b><i>Discussion:</i></b> HbA1c evaluated by CGM underestimates plasma glucose levels in patients receiving HD. The underestimation represents a clinical challenge in optimizing glycemic control in the HD population. Fructosamine is unaffected by the factors affecting HbA1c and appears to be more accurate for glycemic monitoring. CGM or fructosamine could thus complement HbA1c in obtaining more accurate glycemic control in this patient group.



2012 ◽  
Vol 56 (7) ◽  
pp. 449-455 ◽  
Author(s):  
Joel C. Exebio ◽  
Gustavo G. Zarini ◽  
Joan A. Vaccaro ◽  
Cristobal Exebio ◽  
Fatma G. Huffman

OBJECTIVE: To evaluate the validity of hemoglobin A1C (A1C) as a diagnostic tool for type 2 diabetes and to determine the most appropriate A1C cutoff point for diagnosis in a sample of Haitian-Americans. SUBJECTS AND METHODS: Subjects (n = 128) were recruited from Miami-Dade and Broward counties, FL. Receiver operating characteristics (ROC) analysis was run in order to measure sensitivity and specificity of A1C for detecting diabetes at different cutoff points. RESULTS: The area under the ROC curve was 0.86 using fasting plasma glucose ≥ 7.0 mmol/L as the gold standard. An A1C cutoff point of 6.26% had sensitivity of 80% and specificity of 74%, whereas an A1C cutoff point of 6.50% (recommended by the American Diabetes Association - ADA) had sensitivity of 73% and specificity of 89%. CONCLUSIONS: A1C is a reliable alternative to fasting plasma glucose in detecting diabetes in this sample of Haitian-Americans. A cutoff point of 6.26% was the optimum value to detect type 2 diabetes.



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