Enhancing Tumor Drug Delivery by Laser-Activated Vascular Barrier Disruption

2008 ◽  
Author(s):  
Bin Chen ◽  
Chong He
Keyword(s):  
Drug Delivery ◽  
Barrier Disruption ◽  
Tumor Drug Delivery

scholarly journals Harnessing Extracellular Matrix Biology for Tumor Drug Delivery

2021 ◽  
Vol 11 (2) ◽  
pp. 88
Author(s):  
Nithya Subrahmanyam ◽  
Hamidreza Ghandehari
Keyword(s):  
Drug Delivery ◽  
Extracellular Matrix ◽  
Cancer Progression ◽  
Active Role ◽  
Reciprocal Relationship ◽  
Design Parameters ◽  
Cancer Etiology ◽  
Cell Life ◽  
Tumor Drug Delivery ◽  
Signaling Interactions

The extracellular matrix (ECM) plays an active role in cell life through a tightly controlled reciprocal relationship maintained by several fibrous proteins, enzymes, receptors, and other components. It is also highly involved in cancer progression. Because of its role in cancer etiology, the ECM holds opportunities for cancer therapy on several fronts. There are targets in the tumor-associated ECM at the level of signaling molecules, enzyme expression, protein structure, receptor interactions, and others. In particular, the ECM is implicated in invasiveness of tumors through its signaling interactions with cells. By capitalizing on the biology of the tumor microenvironment and the opportunities it presents for intervention, the ECM has been investigated as a therapeutic target, to facilitate drug delivery, and as a prognostic or diagnostic marker for tumor progression and therapeutic intervention. This review summarizes the tumor ECM biology as it relates to drug delivery with emphasis on design parameters targeting the ECM.

scholarly journals Multifunctional exosome-mimetics for targeted anti-glioblastoma therapy by manipulating protein corona

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jun-Yong Wu ◽  
Yong-Jiang Li ◽  
Jiemin Wang ◽  
Xiong-Bin Hu ◽  
Si Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Serum Proteins ◽  
Protein Corona ◽  
Significant Inhibition ◽  
Brain Drug Delivery ◽  
New Strategy ◽  
Penetration Ability ◽  
Tumor Drug Delivery ◽  
Targeting Ability ◽  
Tumor Area

AbstractTargeted drug delivery to the glioblastoma (GBM) overcoming blood–brain barrier (BBB) has been challenging. Exosomes are promising vehicles for brain tumor drug delivery, but the production and purification hinder its application for nanomedicine. Besides, the formation of protein corona (PC) may affect the behaviour of nanocarriers. Here, multifunctional exosomes-mimetics (EM) are developed and decorated with angiopep-2 (Ang) for enhancing GBM drug delivery by manipulating PC. Docetaxel (DTX)-loaded EM with Ang modification (DTX@Ang-EM) show less absorption of serum proteins and phagocytosis by macrophages. Ang-EM show enhanced BBB penetration ability and targeting ability to the GBM. Ang-EM-mediated delivery increase the concentration of DTX in the tumor area. The multifunctional DTX@Ang-EM exhibits significant inhibition effects on orthotopic GBM growth with reduced side effects of the chemotherapeutic. Findings from this study indicate that the developed DTX@Ang-EM provide a new strategy for targeted brain drug delivery and GBM therapy. Graphical abstract

Superselective intra-arterial cerebral infusion to improve brain tumor drug delivery

2021 ◽  
Author(s):  
Julian S Rechberger ◽  
Charlotte A Brown ◽  
Frederic Thiele ◽  
Erica A Power ◽  
David J Daniels
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Tumor Drug Delivery

Graphical abstract [Formula: see text]

scholarly journals Hypoxia-degradable and long-circulating zwitterionic phosphorylcholine-based nanogel for enhanced tumor drug delivery

2020 ◽  
Author(s):  
Shaojun Peng ◽  
Boshu Ouyang ◽  
Yongjie Xin ◽  
Wei Zhao ◽  
Shun Shen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Drug Delivery

scholarly journals Drug-loaded sickle cells programmed ex vivo for delayed hemolysis target hypoxic tumor microvessels and augment tumor drug delivery

2013 ◽  
Vol 171 (2) ◽  
pp. 184-192 ◽  
Author(s):  
Se-woon Choe ◽  
David S. Terman ◽  
Angela E. Rivers ◽  
Jose Rivera ◽  
Richard Lottenberg ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ex Vivo ◽  
Sickle Cells ◽  
Tumor Microvessels ◽  
Tumor Drug Delivery ◽  
Hypoxic Tumor
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