Molecular MR Imaging of Protease Activity in Breast Cancer with Activated Contrast Agents

2008 ◽  
Author(s):  
Dmitri Artemov ◽  
Yoshinori Kato
Keyword(s):  
Breast Cancer ◽  
Mr Imaging ◽  
Contrast Agents ◽  
Protease Activity

Molecular MR Imaging of CD44 in Breast Cancer with Hyaluronan-Based Contrast Agents

2009 ◽  
Author(s):  
Dmitri Artemov ◽  
Wenlian Zhu
Keyword(s):  
Breast Cancer ◽  
Mr Imaging ◽  
Contrast Agents

scholarly journals Cation Exchange Strategy to Construct a Targeting Nanoprobe for Enhanced Positive MR Imaging Capability

2020 ◽  
Author(s):  
Siyu Chen ◽  
Haitao Sun ◽  
Yingyan Zheng ◽  
Qian Chen ◽  
Yu Luo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mr Imaging ◽  
Contrast Agents ◽  
Cation Exchange ◽  
Breast Cancer Cells ◽  
Dose Range ◽  
Iron Chelate ◽  
Good Biocompatibility ◽  
Imaging Performance

Abstract Background: Excellent imaging performance and good biocompatibility of contrast agents are considered as prerequisites for accurate tumor diagnosis and treatment. Results: Herein, a novel imaging nanoprobe with actively targeting performance based on ultrasmall paramagnetic iron oxide (USPIO) was constructed by a facile cation exchange strategy followed by conjugation with transferrin (Tf). The stable gadolinium (Gd3+) chelation endows the nanoparticles (NPs) with a low value of r2/r1 (1.28) and relatively high r1 value of 3.2 mM-1s-1, enabling their use in T1-weighted positive MR imaging.Conclusion: This constructed transferrin modified gadolinium-iron chelate nanoprobe, named as TUG, shows high biocompatibility within a given dose range. More importantly, compared with clinically used Gd-based small molecule contrast agents, the obtained TUG can be more engulfed by breast cancer cells, showing much enhanced T1-weighted positive MR imaging in either subcutaneous or in situ tumor models of breast cancer. This novel nanoprobe holds enormous promise to be utilized as a targeting contrast agent with high efficacy for T1-weighted positive MR imaging.

MR Imaging with Histopathological Correlation in Vertebral Metastases of Breast Cancer

1992 ◽  
Vol 33 (3) ◽  
pp. 213-220 ◽  
Author(s):  
M. Petren-Mallmin ◽  
B. Nordstrom ◽  
I. Andreasson ◽  
R. Nyman ◽  
H. Jonsson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mr Imaging ◽  
Vertebral Metastases ◽  
Histopathological Correlation

MR Imaging and Gene Therapy of Breast Cancer

2001 ◽  
Author(s):  
Min-Ying Su
Keyword(s):  
Breast Cancer ◽  
Gene Therapy ◽  
Mr Imaging

Contrast agents for MR imaging of the liver: a clinical overview

1997 ◽  
Vol 7 (4) ◽  
pp. 507-513 ◽  
Author(s):  
A.-E. Mahfouz ◽  
B. Hamm ◽  
M. Taupitz
Keyword(s):  
Mr Imaging ◽  
Contrast Agents ◽  
Clinical Overview

Global Protease Activity Profiling Identifies HER2-Driven Proteolysis in Breast Cancer

2021 ◽  
Author(s):  
Eugenia C. Salcedo ◽  
Michael B. Winter ◽  
Natalia Khuri ◽  
Giselle M. Knudsen ◽  
Andrej Sali ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protease Activity ◽  
Activity Profiling

MR IMAGING: ITS CURRENT AND POTENTIAL UTILITY IN THE DIAGNOSIS AND MANAGEMENT OF BREAST CANCER

2000 ◽  
Vol 8 (4) ◽  
pp. 715-728
Author(s):  
Nitin A. Kumar ◽  
Mitchell D. Schnall
Keyword(s):  
Breast Cancer ◽  
Mr Imaging ◽  
Potential Utility ◽  
Diagnosis And Management

Enhancement pattern of hepatocellular adenoma (HCA) on MR imaging performed with Gd-EOB-DTPA versus other Gd-based contrast agents (GBCAs): An intraindividual comparison

2019 ◽  
Vol 119 ◽  
pp. 108633 ◽  
Author(s):  
Roberto Cannella ◽  
Giuseppe Brancatelli ◽  
Balasubramanya Rangaswamy ◽  
Marta I. Minervini ◽  
Amir A. Borhani ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Contrast Agents ◽  
Hepatocellular Adenoma ◽  
Enhancement Pattern ◽  
Intraindividual Comparison

Value of Combined FDG PET and MR Imaging in the Evaluation of Suspected Recurrent Local-Regional Breast Cancer: Preliminary Experience

Radiology ◽  
1999 ◽  
Vol 210 (3) ◽  
pp. 807-814 ◽  
Author(s):  
Peter B. Hathaway ◽  
David A. Mankoff ◽  
Kenneth R. Maravilla ◽  
Mary M. Austin-Seymour ◽  
Georgiana K. Ellis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mr Imaging ◽  
Fdg Pet
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