Global Protease Activity Profiling Identifies HER2-Driven Proteolysis in Breast Cancer

2021 ◽  
Author(s):  
Eugenia C. Salcedo ◽  
Michael B. Winter ◽  
Natalia Khuri ◽  
Giselle M. Knudsen ◽  
Andrej Sali ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protease Activity ◽  
Activity Profiling

scholarly journals Pathway activity profiling of growth factor receptor network and stemness pathways differentiates metaplastic breast cancer histological subtypes

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jasmine A. McQuerry ◽  
David F. Jenkins ◽  
Susan E. Yost ◽  
Yuqing Zhang ◽  
Daniel Schmolze ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Histological Subtypes ◽  
Metaplastic Breast Cancer ◽  
Pathway Activity ◽  
Activity Profiling

scholarly journals Predictive models of protease specificity based on quantitative protease-activity profiling data

2019 ◽  
Vol 1867 (11) ◽  
pp. 140253
Author(s):  
Gennady G. Fedonin ◽  
Alexey Eroshkin ◽  
Piotr Cieplak ◽  
Evgenii V. Matveev ◽  
Gennady V. Ponomarev ◽  
...  
Keyword(s):  
Predictive Models ◽  
Protease Activity ◽  
Activity Profiling ◽  
Protease Specificity

Caspase-3 inhibits the growth of breast cancer cells independent of protease activity

2004 ◽  
Vol 202 (2) ◽  
pp. 478-482 ◽  
Author(s):  
Beatrice Faraglia ◽  
Alessia Bonsignore ◽  
Franco Scaldaferri ◽  
Alma Boninsegna ◽  
Achille Cittadini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Protease Activity ◽  
Breast Cancer Cells ◽  
Caspase 3

scholarly journals Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis

2019 ◽  
Vol 26 (6) ◽  
pp. 1460-1473 ◽  
Author(s):  
Sijia Liu ◽  
Román González-Prieto ◽  
Mengdi Zhang ◽  
Paul P. Geurink ◽  
Raymond Kooij ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Activity Profiling

scholarly journals Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection

2016 ◽  
Vol 7 ◽  
pp. 364-373 ◽  
Author(s):  
Dinusha N Udukala ◽  
Hongwang Wang ◽  
Sebastian O Wendel ◽  
Aruni P Malalasekera ◽  
Thilani N Samarakoon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protease Activity ◽  
Early Cancer ◽  
Consensus Sequence ◽  
Tumor Biology ◽  
Surrounding Tissue ◽  
Breast Cancer Patients ◽  
Liquid Biopsies ◽  
Limits Of Detection ◽  
Early Cancer Diagnosis

Proteases, including matrix metalloproteinases (MMPs), tissue serine proteases, and cathepsins (CTS) exhibit numerous functions in tumor biology. Solid tumors are characterized by changes in protease expression levels by tumor and surrounding tissue. Therefore, monitoring protease levels in tissue samples and liquid biopsies is a vital strategy for early cancer detection. Water-dispersable Fe/Fe3O4-core/shell based nanoplatforms for protease detection are capable of detecting protease activity down to sub-femtomolar limits of detection. They feature one dye (tetrakis(carboxyphenyl)porphyrin (TCPP)) that is tethered to the central nanoparticle by means of a protease-cleavable consensus sequence and a second dye (Cy 5.5) that is directly linked. Based on the protease activities of urokinase plasminogen activator (uPA), MMPs 1, 2, 3, 7, 9, and 13, as well as CTS B and L, human breast cancer can be detected at stage I by means of a simple serum test. By monitoring CTS B and L stage 0 detection may be achieved. This initial study, comprised of 46 breast cancer patients and 20 apparently healthy human subjects, demonstrates the feasibility of protease-activity-based liquid biopsies for early cancer diagnosis.

scholarly journals Dynamic Model of Protease State and Inhibitor Trafficking to Predict Protease Activity in Breast Cancer Cells

2019 ◽  
Vol 12 (4) ◽  
pp. 275-288
Author(s):  
W. Andrew Shockey ◽  
Christopher A. Kieslich ◽  
Catera L. Wilder ◽  
Valencia Watson ◽  
Manu O. Platt
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Dynamic Model ◽  
Protease Activity ◽  
Breast Cancer Cells

scholarly journals Protease Activity Profiling via Programmable Phage Display of Comprehensive Proteome-Scale Peptide Libraries

Cell Systems ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 375-381.e4
Author(s):  
Gabriel D. Román-Meléndez ◽  
Thiagarajan Venkataraman ◽  
Daniel R. Monaco ◽  
H. Benjamin Larman
Keyword(s):  
Phage Display ◽  
Protease Activity ◽  
Peptide Libraries ◽  
Activity Profiling

Mass Spectrometry-Cleavable Protein N-Terminal Tagging Strategy for System-Level Protease Activity Profiling

2021 ◽  
Author(s):  
Zixiang Fang ◽  
Maheshika S. K. Wanigasekara ◽  
Akop Yepremyan ◽  
Brandon Lam ◽  
Pawan Thapa ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Protease Activity ◽  
System Level ◽  
Activity Profiling

Molecular MR Imaging of Protease Activity in Breast Cancer with Activated Contrast Agents

2008 ◽  
Author(s):  
Dmitri Artemov ◽  
Yoshinori Kato
Keyword(s):  
Breast Cancer ◽  
Mr Imaging ◽  
Contrast Agents ◽  
Protease Activity
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