Novel and Efficient Synthesis of the Promising Drug Candidate Discodermolide

2010 ◽  
Author(s):  
Kathlyn A. Parker
Keyword(s):  
Drug Candidate ◽  
Efficient Synthesis

Late-Stage Sulfoximination: Improved Synthesis of the Anticancer Drug Candidate Atuveciclib

Synthesis ◽  
2018 ◽  
Vol 51 (04) ◽  
pp. 971-975 ◽  
Author(s):  
Vincent Reboul ◽  
Thomas Glachet ◽  
Xavier Franck
Keyword(s):  
Anticancer Drug ◽  
Late Stage ◽  
Drug Candidate ◽  
Efficient Synthesis ◽  
Reaction Conditions

An efficient synthesis of racemic atuveciclib was accomplished in five steps with an excellent 51% overall yield, using cheap reagents and mild reaction conditions. The key sulfoximination reaction was realized during the last step of the synthesis from the corresponding sulfide.

Efficient Synthesis of a Highly Selective NPY-5 Receptor Antagonist:  A Drug Candidate for the Treatment of Obesity

2006 ◽  
Vol 10 (4) ◽  
pp. 822-828 ◽  
Author(s):  
Takahiro Itoh ◽  
Shinji Kato ◽  
Nobuaki Nonoyama ◽  
Toshihiro Wada ◽  
Kenji Maeda ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Drug Candidate ◽  
Efficient Synthesis ◽  
Treatment Of Obesity

A new facile and efficient synthesis of trans-(+)-sobrerol by biotransformation of α-pinene using extremophiles microorganisms

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
LA Vilaseca ◽  
J Quillaguamán ◽  
L Fuentes ◽  
O Sterner
Keyword(s):  
Efficient Synthesis

Thin-layer chromatographic characterization of metabolites formed from an AMPA antagonist drug candidate

2001 ◽  
Vol 14 (4) ◽  
pp. 266-271 ◽  
Author(s):  
Katalin Migléczi ◽  
István Hazai ◽  
Katalin Jemnitz ◽  
Márta Pátfalusi
Keyword(s):  
Thin Layer ◽  
Drug Candidate ◽  
Ampa Antagonist ◽  
Chromatographic Characterization
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