Although osteosarcoma is the most common primary bone cancer, the incidence in head and neck bony structures is extremely low. As the surgical treatment requires a wide margin excision, the operation usually will be very challenging especially if it involves midline structures. We report a case of a young gentleman who had a bony growth over the epicenter of the hard palate which rapidly occupies the whole oral cavity within 6 months duration. The outline of management is discussed. Keywords: Osteosarcoma; hard palate. DOI: 10.3329/bjms.v10i1.7322 Bangladesh Journal of Medical Science Vol.10 No.1 Jan 2010 pp.57-59