scholarly journals The Effects of Minocycline on Spinal Root Avulsion Injury in Rat Model

2017 ◽  
Vol 24 (1) ◽  
pp. 31-39 ◽  
Author(s):  
Tan Yew Chin ◽  
◽  
Sim Sze Kiat ◽  
Hizal Ghazali Faizul ◽  
Wutian Wu ◽  
...  
Keyword(s):  
Rat Model ◽  
Root Avulsion ◽  
Spinal Root ◽  
Avulsion Injury

Segmental Spinal Root Avulsion in the Adult Rat: A Model To Study Avulsion Injury Pain

2013 ◽  
Vol 30 (3) ◽  
pp. 160-172 ◽  
Author(s):  
Daniel J. Chew ◽  
Karen Murrell ◽  
Thomas Carlstedt ◽  
Peter J. Shortland
Keyword(s):  
Root Avulsion ◽  
Spinal Root ◽  
Avulsion Injury ◽  
Adult Rat

scholarly journals PLGA-PEG-PLGA hydrogel with NEP1-40 promotes the functional recovery of brachial plexus root avulsion in adult rats

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e12269
Author(s):  
Wenlai Guo ◽  
Bingbing Pei ◽  
Zehui Li ◽  
Xiao Lan Ou ◽  
Tianwen Sun ◽  
...  
Keyword(s):  
Brachial Plexus ◽  
Functional Recovery ◽  
Rat Model ◽  
Nerve Root ◽  
Axonal Regeneration ◽  
Biceps Brachii ◽  
Nerve Tissue ◽  
Root Avulsion ◽  
Avulsion Injury ◽  
Nerve Root Avulsion

Adult brachial plexus root avulsion can cause serious damage to nerve tissue and impair axonal regeneration, making the recovery of nerve function difficult. Nogo-A extracellular peptide residues 1-40 (NEP1-40) promote axonal regeneration by inhibiting the Nogo-66 receptor (NgR1), and poly (D, L-lactide-co-glycolide)-poly (ethylene glycol)-poly (D, L-lactide-co-glycolide) (PLGA-PEG-PLGA) hydrogel can be used to fill in tissue defects and concurrently function to sustain the release of NEP1-40. In this study, we established an adult rat model of brachial plexus nerve root avulsion injury and conducted nerve root replantation. PLGA-PEG-PLGA hydrogel combined with NEP1-40 was used to promote nerve regeneration and functional recovery in this rat model. Our results demonstrated that functional recovery was enhanced, and the survival rate of spinal anterior horn motoneurons was higher in rats that received a combination of PLGA-PEG-PLGA hydrogel and NEP1-40 than in those receiving other treatments. The combined therapy also significantly increased the number of fluorescent retrogradely labeled neurons, muscle fiber diameter, and motor endplate area of the biceps brachii. In conclusion, this study demonstrates that the effects of PLGA-PEG-PLGA hydrogel combined with NEP1-40 are superior to those of other therapies used to treat brachial plexus nerve root avulsion injury. Therefore, future studies should investigate the potential of PLGA-PEG-PLGA hydrogel as a primary treatment for brachial plexus root avulsion.

Vascular changes associated with spinal root avulsion injury

2015 ◽  
Vol 32 (3) ◽  
pp. 158-162 ◽  
Author(s):  
Vincent Cibert-Goton ◽  
Justin P. Phillips ◽  
Peter J. Shortland
Keyword(s):  
Root Avulsion ◽  
Vascular Changes ◽  
Spinal Root ◽  
Avulsion Injury

Therapies of pain due to spinal root avulsion

Pain ◽  
1981 ◽  
Vol 11 ◽  
pp. S84
Author(s):  
Wynn C.B. Parry
Keyword(s):  
Root Avulsion ◽  
Spinal Root

Survival, regeneration and functional recovery of motoneurons in adult rats by reimplantation of ventral root following spinal root avulsion

2004 ◽  
Vol 19 (8) ◽  
pp. 2123-2131 ◽  
Author(s):  
Huai-Yu Gu ◽  
Hong Chai ◽  
Jian-Yi Zhang ◽  
Zhi-Bin Yao ◽  
Li-Hua Zhou ◽  
...  
Keyword(s):  
Functional Recovery ◽  
Ventral Root ◽  
Root Avulsion ◽  
Spinal Root ◽  
Adult Rats

GDNF and BDNF Alter the Expression of Neuronal NOS, c-Jun, and p75 and Prevent Motoneuron Death following Spinal Root Avulsion in Adult Rats

2003 ◽  
Vol 20 (6) ◽  
pp. 603-612 ◽  
Author(s):  
Wutian Wu ◽  
Linxi Li ◽  
Leung-Wah Yick ◽  
Hong Chai ◽  
Yuanyun Xie ◽  
...  
Keyword(s):  
Root Avulsion ◽  
Spinal Root ◽  
Adult Rats ◽  
Neuronal Nos
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