Strategic Responses to Peer-Firm Financial Flexibility: Evidence from Indirect Treatment Effects

Author(s):  
James Nordlund

2020 ◽  
Vol 9 (10) ◽  
pp. 737-750
Author(s):  
Elyse Swallow ◽  
Oscar Patterson-Lomba ◽  
Rajeev Ayyagari ◽  
Corey Pelletier ◽  
Rina Mehta ◽  
...  

Aim: To illustrate that bias associated with indirect treatment comparison and network meta-analyses can be reduced by adjusting for outcomes on common reference arms. Materials & methods: Approaches to adjusting for reference-arm effects are presented within a causal inference framework. Bayesian and Frequentist approaches are applied to three real data examples. Results: Reference-arm adjustment can significantly impact estimated treatment differences, improve model fit and align indirectly estimated treatment effects with those observed in randomized trials. Reference-arm adjustment can possibly reverse the direction of estimated treatment effects. Conclusion: Accumulating theoretical and empirical evidence underscores the importance of adjusting for reference-arm outcomes in indirect treatment comparison and network meta-analyses to make full use of data and reduce the risk of bias in estimated treatments effects.



2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Martin Huber ◽  
Kaspar Wüthrich

Abstract This paper provides a review of methodological advancements in the evaluation of heterogeneous treatment effect models based on instrumental variable (IV) methods. We focus on models that achieve identification by assuming monotonicity of the treatment in the IV and analyze local average and quantile treatment effects for the subpopulation of compliers. We start with a comprehensive discussion of the binary treatment and binary IV case as for instance relevant in randomized experiments with imperfect compliance. We then review extensions to identification and estimation with covariates, multi-valued and multiple treatments and instruments, outcome attrition and measurement error, and the identification of direct and indirect treatment effects, among others. We also discuss testable implications and possible relaxations of the IV assumptions, approaches to extrapolate from local to global treatment effects, and the relationship to other IV approaches.



2012 ◽  
Vol 50 (4) ◽  
pp. 1125-1132 ◽  
Author(s):  
Karim El-Basyouny ◽  
Tarek Sayed




2016 ◽  
Vol 44 (11) ◽  
pp. 2729-2737 ◽  
Author(s):  
Kun Liu ◽  
Chenying Wang ◽  
Huimin Hu ◽  
Juzhang Lei ◽  
Leng Han


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