Pembrolizumab as Neoadjuvant Therapy Preceding Radical Cystectomy in Patients with Muscle-Invasive Urothelial Bladder Carcinoma (PURE-01): An Open-Label, Single-Group, Phase 2 Study

Phase 2 Study ◽

Urothelial Bladder ◽

PURE01: An open label, single-arm, phase 2 study of the anti-programmed death (PD)-1 monoclonal antibody (moAb) pembrolizumab for neoadjuvant therapy of muscle-invasive urothelial bladder carcinoma (miUBC)

Annals of Oncology ◽

10.1093/annonc/mdw373.74 ◽

2016 ◽

Vol 27 ◽

pp. vi294

Author(s):

A. Necchi ◽

L. Mariani ◽

A. Anichini ◽

P. Giannatempo ◽

D. Raggi ◽

...

Keyword(s):

Monoclonal Antibody ◽

Neoadjuvant Therapy ◽

Bladder Carcinoma ◽

Phase 2 ◽

Open Label ◽

Programmed Death ◽

Phase 2 Study ◽

Urothelial Bladder ◽

PURE01: An open label, single-arm, phase 2 study of the anti-programmed death (PD)-1 monoclonal antibody (moAb) pembrolizumab for neoadjuvant therapy of muscle-invasive urothelial bladder carcinoma (miUBC)

European Urology Supplements ◽

10.1016/s1569-9056(17)30277-4 ◽

2017 ◽

Vol 16 (3) ◽

pp. e365-e366

Author(s):

A. Necchi ◽

L. Mariani ◽

A. Anichini ◽

P. Giannatempo ◽

D. Raggi ◽

...

Keyword(s):

Monoclonal Antibody ◽

Neoadjuvant Therapy ◽

Bladder Carcinoma ◽

Phase 2 ◽

Open Label ◽

Programmed Death ◽

Phase 2 Study ◽

Urothelial Bladder ◽

Faculty Opinions recommendation of Pembrolizumab as Neoadjuvant Therapy Before Radical Cystectomy in Patients With Muscle-Invasive Urothelial Bladder Carcinoma (PURE-01): An Open-Label, Single-Arm, Phase II Study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.734259396.793578102 ◽

2020 ◽

Author(s):

Matthew Milowsky

Keyword(s):

Neoadjuvant Therapy ◽

Radical Cystectomy ◽

Phase Ii ◽

Bladder Carcinoma ◽

Phase Ii Study ◽

Open Label ◽

Urothelial Bladder ◽

Re: Pembrolizumab as Neoadjuvant Therapy Before Radical Cystectomy in Patients with Muscle-invasive Urothelial Bladder Carcinoma (PURE-01): An Open-label, Single-arm, Phase II Study

European Urology ◽

10.1016/j.eururo.2018.12.034 ◽

2019 ◽

Vol 75 (4) ◽

pp. 695-696 ◽

Cited By ~ 1

Author(s):

Kilian M. Gust ◽

Shahrokh F. Shariat

Keyword(s):

Neoadjuvant Therapy ◽

Radical Cystectomy ◽

Phase Ii ◽

Bladder Carcinoma ◽

Phase Ii Study ◽

Open Label ◽

Urothelial Bladder ◽

Neoadjuvant sorafenib, gemcitabine, and cisplatin administration preceding cystectomy in patients with muscle-invasive urothelial bladder carcinoma: An open-label, single-arm, single-center, phase 2 study

Urologic Oncology Seminars and Original Investigations ◽

10.1016/j.urolonc.2017.08.020 ◽

2018 ◽

Vol 36 (1) ◽

pp. 8.e1-8.e8 ◽

Cited By ~ 4

Author(s):

Andrea Necchi ◽

Salvatore Lo Vullo ◽

Daniele Raggi ◽

Federica Perrone ◽

Patrizia Giannatempo ◽

...

Keyword(s):

Bladder Carcinoma ◽

Phase 2 ◽

Single Center ◽

Open Label ◽

Phase 2 Study ◽

Urothelial Bladder ◽

Muscle Invasive ◽

Gemcitabine And Cisplatin

PD11-11 INTERIM RESULTS FROM PURE-01: A PHASE 2, OPEN-LABEL STUDY OF NEOADJUVANT PEMBROLIZUMAB (PEMBRO) BEFORE RADICAL CYSTECTOMY FOR MUSCLE-INVASIVE UROTHELIAL BLADDER CARCINOMA (MIUC)

The Journal of Urology ◽

10.1016/j.juro.2018.02.634 ◽

2018 ◽

Vol 199 (4S) ◽

Author(s):

Andrea Necchi ◽

Alberto Briganti ◽

Daniele Raggi ◽

Patrizia Giannatempo ◽

Marco Bianchi ◽

...

Keyword(s):

Radical Cystectomy ◽

Bladder Carcinoma ◽

Phase 2 ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Urothelial Bladder ◽

Early surgical safety outcomes from PURE-01: Secondary analysis from a phase 2 open-label study of neoadjuvant pembrolizumab (pembro) before radical cystectomy for muscle-invasive urothelial bladder carcinoma (MIUC)

European Urology Supplements ◽

10.1016/s1569-9056(18)31211-9 ◽

2018 ◽

Vol 17 (2) ◽

pp. e523-e524 ◽

Cited By ~ 1

Author(s):

A. Briganti ◽

A. Necchi ◽

D. Raggi ◽

P. Giannatempo ◽

M. Bianchi ◽

...

Keyword(s):

Bladder Carcinoma ◽

Secondary Analysis ◽

Phase 2 ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Surgical Safety ◽

Urothelial Bladder ◽

PECULIAR: An open label, multicenter, single-arm, phase 2 study of neoadjuvant pembrolizumab (PEM) and epacadostat (EPA), preceding radical cystectomy (Cy), for patients (pts) with muscle-invasive urothelial bladder cancer (MIUBC).

Journal of Clinical Oncology ◽

10.1200/jco.2018.36.15_suppl.tps4595 ◽

2018 ◽

Vol 36 (15_suppl) ◽

pp. TPS4595-TPS4595

Author(s):

Andrea Necchi ◽

Alberto Briganti ◽

Marco Bianchi ◽

Daniele Raggi ◽

Patrizia Giannatempo ◽

...

Keyword(s):

Bladder Cancer ◽

Radical Cystectomy ◽

Phase 2 ◽

Urothelial Bladder Cancer ◽

Open Label ◽

Phase 2 Study ◽

Urothelial Bladder ◽

2643 Neoadjuvant sorafenib, gemcitabine, and cisplatin (SGC) for muscle-invasive urothelial bladder cancer (UBC): Updated clinical and translational findings of an open-label, single group, phase 2 study

European Journal of Cancer ◽

10.1016/s0959-8049(16)31460-5 ◽

2015 ◽

Vol 51 ◽

pp. S528

Author(s):

A. Necchi ◽

P. Giannatempo ◽

L. Mariani ◽

D. Raggi ◽

N. Nicolai ◽

...

Keyword(s):

Bladder Cancer ◽

Phase 2 ◽

Single Group ◽

Urothelial Bladder Cancer ◽

Open Label ◽

Phase 2 Study ◽

Urothelial Bladder ◽

Muscle Invasive ◽

Gemcitabine And Cisplatin

Preoperative pembrolizumab (pembro) before radical cystectomy (RC) for muscle-invasive urothelial bladder carcinoma (MIUC): Interim clinical and biomarker findings from the phase 2 PURE-01 study.

Journal of Clinical Oncology ◽

10.1200/jco.2018.36.15_suppl.4507 ◽

2018 ◽

Vol 36 (15_suppl) ◽

pp. 4507-4507 ◽

Cited By ~ 13

Author(s):

Andrea Necchi ◽

Alberto Briganti ◽

Marco Bianchi ◽

Daniele Raggi ◽

Patrizia Giannatempo ◽

...

Keyword(s):

Radical Cystectomy ◽

Bladder Carcinoma ◽

Phase 2 ◽

Urothelial Bladder ◽