scholarly journals Inhibitory Co-Transmission from Midbrain Dopamine Neurons Relies on Presynaptic GABA Uptake

2021 ◽  
Author(s):  
Riccardo Melani ◽  
Nicolas Xavier Tritsch
Keyword(s):  
Dopamine Neurons ◽  
Gaba Uptake ◽  
Midbrain Dopamine ◽  
Midbrain Dopamine Neurons

scholarly journals Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Nicolas X Tritsch ◽  
Won-Jong Oh ◽  
Chenghua Gu ◽  
Bernardo L Sabatini
Keyword(s):  
Dopaminergic Neurons ◽  
De Novo ◽  
Dopamine Neurons ◽  
Gaba Uptake ◽  
Projection Neurons ◽  
Dependent Manner ◽  
Gaba Transporters ◽  
Midbrain Dopamine ◽  
Nigrostriatal Dopamine Neurons ◽  
Midbrain Dopamine Neurons

Synaptic transmission between midbrain dopamine neurons and target neurons in the striatum is essential for the selection and reinforcement of movements. Recent evidence indicates that nigrostriatal dopamine neurons inhibit striatal projection neurons by releasing a neurotransmitter that activates GABAA receptors. Here, we demonstrate that this phenomenon extends to mesolimbic afferents, and confirm that the released neurotransmitter is GABA. However, the GABA synthetic enzymes GAD65 and GAD67 are not detected in midbrain dopamine neurons. Instead, these cells express the membrane GABA transporters mGAT1 (Slc6a1) and mGAT4 (Slc6a11) and inhibition of these transporters prevents GABA co-release. These findings therefore indicate that GABA co-release is a general feature of midbrain dopaminergic neurons that relies on GABA uptake from the extracellular milieu as opposed to de novo synthesis. This atypical mechanism may confer dopaminergic neurons the flexibility to differentially control GABAergic transmission in a target-dependent manner across their extensive axonal arbors.

Molecular heterogeneity of midbrain dopamine neurons

2016 ◽  
Vol 4 (Suppl. 2) ◽  
pp. A2.1
Author(s):  
Siew-Lan Ang
Keyword(s):  
Dopamine Neurons ◽  
Molecular Heterogeneity ◽  
Midbrain Dopamine ◽  
Midbrain Dopamine Neurons

Deletion of VGLUT2 in midbrain dopamine neurons attenuates dopamine and glutamate responses to methamphetamine in mice

2021 ◽  
Vol 202 ◽  
pp. 173104
Author(s):  
Hui Shen ◽  
Kai Chen ◽  
Rosa Anna M. Marino ◽  
Ross A. McDevitt ◽  
Zheng-Xiong Xi
Keyword(s):  
Dopamine Neurons ◽  
Midbrain Dopamine ◽  
Midbrain Dopamine Neurons

scholarly journals Cell-Autonomous Excitation of Midbrain Dopamine Neurons by Endocannabinoid-Dependent Lipid Signaling

Neuron ◽  
2017 ◽  
Vol 93 (6) ◽  
pp. 1375-1387.e2 ◽  
Author(s):  
Stephanie C. Gantz ◽  
Bruce P. Bean
Keyword(s):  
Dopamine Neurons ◽  
Lipid Signaling ◽  
Midbrain Dopamine ◽  
Midbrain Dopamine Neurons
Sign in / Sign up

Export Citation Format

Share Document