Prevalence and Antimicrobial Resistance of Group A Streptococcus Isolates in Scarlet Fever Cases From Pediatric Patients in Shenzhen, China

2022 ◽  
Author(s):  
Lifang Sun ◽  
Yunju Xiao ◽  
Weilong Huang ◽  
Jianwei Lai ◽  
Jingwen Lyu ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Scarlet Fever ◽  
Group A Streptococcus ◽  
Group A

scholarly journals Identification of epidemic scarlet fever group A Streptococcus strains in the paediatric population of Houston, TX, USA

2021 ◽  
Vol 3 (10) ◽  
Author(s):  
M. Belen Cubria ◽  
Jose Delgado ◽  
Brittany J. Shah ◽  
Misu A. Sanson ◽  
Anthony R. Flores
Keyword(s):  
Antimicrobial Resistance ◽  
Scarlet Fever ◽  
Sequence Data ◽  
Group A Streptococcus ◽  
Paediatric Population ◽  
Resistance Pattern ◽  
Whole Genome ◽  
National Surveillance ◽  
The Usa ◽  
Group A

Scarlet fever (SF) has recently been associated with group A streptococcal (GAS) strains possessing multidrug resistance and specific streptococcal exotoxins. We screened a local surveillance collection of GAS emm12 strains in Houston, TX, USA for antimicrobial resistance and identified a single isolate matching the antimicrobial resistance pattern previously reported for SF clones. Using whole-genome sequencing and combining genome sequence data derived from national surveillance databases, we identified additional emm12 GAS clones similar to those associated with prior SF outbreaks, emphasizing the need for continued surveillance for epidemic emergence in the USA.

scholarly journals Unexpected relationships between frequency of antimicrobial resistance, disease phenotype and emm type in group A Streptococcus

2019 ◽  
Vol 5 (11) ◽  
Author(s):  
Misu A. Sanson ◽  
Olga R. Macias ◽  
Brittany J. Shah ◽  
Blake Hanson ◽  
Luis Alberto Vega ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Group A Streptococcus ◽  
Disease Phenotype ◽  
Group A ◽  
Emm Type

scholarly journals Molecular epidemiology and antimicrobial resistance of group A streptococcus recovered from patients in Beijing, China

2020 ◽  
Author(s):  
Hongxin Li ◽  
Lin Zhou ◽  
Yong Zhao ◽  
Lijuan Ma ◽  
Xiaoyan Liu ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Group A Streptococcus ◽  
Resistance Rate ◽  
Gene Profiling ◽  
Epidemiological Surveillance ◽  
Erythromycin Resistance ◽  
Children's Hospital ◽  
Children’S Hospital ◽  
Group A ◽  
Epidemiological Characteristics

Abstract Background: Group A streptococcus (GAS) is an important human pathogen responsible for a broad range of infections. Epidemiological surveillance has been crucial to detect changes in the geographical and temporal variation of the disease pattern. The objective of this study was to investigate the molecular epidemiological characteristics and antimicrobial resistance of GAS isolates from patients in Children’s Hospital in Beijing. Methods: From 2016 to 2017, pharyngeal swab samples were collected from the outpatients in Children’s Hospital, Capital Institute of Pediatrics, who were diagnosed with scarlet fever. Antimicrobial susceptibility test was performed according to the distribution of conventional antibiotics and Clinical and Laboratory Standards Institute (CLSI) recommendations. The distribution of the macrolide-resistance genes ( ermB, ermA, mefA ), emm (M protein-coding gene) typing, and superantigens (SAg) gene profiling were examined by polymerase chain reaction (PCR). Results: A total of 297 GAS isolates were collected. The susceptibility of the isolates to penicillin, ceftriaxone, and levofloxacin was 100%. The resistance rate to erythromycin and clindamycin was 98.3% and 96.6%, respectively. The dominant emm types were emm12 (65.32%), emm1 (27.61%), emm75 (2.69%), and emm89 (1.35%). Of the 297 isolates, 290 (97.64%) carried the ermB gene, and 5 (1.68%) carried the mefA gene, while none carried the ermA gene. The most common superantigen genes identified from GAS isolates were smeZ (96.97%) , speC (92.59%), speG (91.58%), ssa (85.52%), speI (54.55%), speH (52.19%), and speA (34.34%). Isolates with the genotype emm1 possessed speA , speC , speG , speJ , speM , ssa , and smeZ , while emm12 possessed speC , speG , speH , speI , speM , ssa , and smeZ superantigens. Conclusions: The prevalent strain of GAS isolates in Beijing has a high resistance rate to macrolides; however, penicillin can still be the preferred antibiotic for treatment. Erythromycin resistance was predominantly mediated by ermB. The common emm types were emm12 and emm1. There was a correlation between emm and the superantigen gene. Thus, long-term monitoring and investigation of the emm types and superantigen genes of GAS prevalence are imperative.

Molecular epidemiology of group A streptococcus causing scarlet fever in northern Taiwan, 2001–2002

2007 ◽  
Vol 58 (3) ◽  
pp. 289-295 ◽  
Author(s):  
Ying-Yan Chen ◽  
Chung-Ter Huang ◽  
Shu-Man Yao ◽  
Yi-Ching Chang ◽  
Pei-Wun Shen ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Scarlet Fever ◽  
Group A Streptococcus ◽  
Group A ◽  
Northern Taiwan

scholarly journals Molecular epidemiology and antimicrobial resistance of group a streptococcus recovered from patients in Beijing, China

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Hongxin Li ◽  
Lin Zhou ◽  
Yong Zhao ◽  
Lijuan Ma ◽  
Xiaoyan Liu ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Molecular Epidemiology ◽  
Group A Streptococcus ◽  
Group A ◽  
Beijing China

Inhibition of the Scarlet Fever Exanthem in Concurrent Varicella and Group A Streptococcus Infection

1993 ◽  
Vol 16 (2) ◽  
pp. 286-287 ◽  
Author(s):  
M. A. Friedman ◽  
J. D. Klein ◽  
S. C. Eppes
Keyword(s):  
Scarlet Fever ◽  
Group A Streptococcus ◽  
Group A

Outbreak of Scarlet Fever Associated With emm12 Type Group A Streptococcus in 2011 in Shanghai, China

2012 ◽  
Vol 31 (9) ◽  
pp. e158-e162 ◽  
Author(s):  
Mingliang Chen ◽  
Weilei Yao ◽  
Xiaohong Wang ◽  
Yuefang Li ◽  
Min Chen ◽  
...  
Keyword(s):  
Scarlet Fever ◽  
Group A Streptococcus ◽  
Type Group ◽  
Group A

scholarly journals Transfer of scarlet fever-associated elements into the group A Streptococcus M1T1 clone

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Nouri L. Ben Zakour ◽  
Mark R. Davies ◽  
Yuanhai You ◽  
Jonathan H. K. Chen ◽  
Brian M. Forde ◽  
...  
Keyword(s):  
Scarlet Fever ◽  
Group A Streptococcus ◽  
Group A

scholarly journals Molecular epidemiology and antimicrobial resistance of group A streptococcus recovered from patients in Beijing, China

2020 ◽  
Author(s):  
Hongxin Li ◽  
Lin Zhou ◽  
Yong Zhao ◽  
Lijuan Ma ◽  
Xiaoyan Liu ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Group A Streptococcus ◽  
Resistance Rate ◽  
Gene Profiling ◽  
Epidemiological Surveillance ◽  
Erythromycin Resistance ◽  
Children's Hospital ◽  
Children’S Hospital ◽  
Group A ◽  
Epidemiological Characteristics

Abstract Background: Group A streptococcus (GAS) is an important human pathogen responsible for a broad range of infections. Epidemiological surveillance has been crucial to detect changes in the geographical and temporal variation of the disease pattern. The objective of this study was to investigate the molecular epidemiological characteristics and antimicrobial resistance of GAS isolates from patients in Children’s Hospital in Beijing. Methods: From 2016 to 2017, pharyngeal swab samples were collected from the outpatients in Children’s Hospital, Capital Institute of Pediatrics, who were diagnosed with scarlet fever. Antimicrobial susceptibility test was performed according to the distribution of conventional antibiotics and Clinical and Laboratory Standards Institute (CLSI) recommendations. The distribution of the macrolide-resistance genes (ermB, ermA, mefA), emm (M protein-coding gene) typing, and superantigens (SAg) gene profiling were examined by polymerase chain reaction (PCR). Results: A total of 297 GAS isolates were collected. The susceptibility of the isolates to penicillin, ceftriaxone, and levofloxacin was 100%. The resistance rate to erythromycin and clindamycin was 98.3% and 96.6%, respectively. The dominant emm types were emm12 (65.32%), emm1 (27.61%), emm75 (2.69%), and emm89 (1.35%). Of the 297 isolates, 290 (97.64%) carried the ermB gene, and 5 (1.68%) carried the mefA gene, while none carried the ermA gene. The most common superantigen genes identified from GAS isolates were smeZ (96.97%), speC (92.59%), speG (91.58%), ssa (85.52%), speI (54.55%), speH (52.19%), and speA (34.34%). Isolates with the genotype emm1 possessed speA, speC, speG, speJ, speM, ssa, and smeZ, while emm12 possessed speC, speG, speH, speI, speM, ssa, and smeZ superantigens. Conclusions: The prevalent strain of GAS isolates in Beijing has a high resistance rate to macrolides; however, penicillin can still be the preferred antibiotic for treatment. Erythromycin resistance was predominantly mediated by ermB. The common emm types were emm12 and emm1. There was a correlation between emm and the superantigen gene. Thus, long-term monitoring and investigation of the emm types and superantigen genes of GAS prevalence are imperative.

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