scholarly journals Clinicopathological Features and Prognosis of Primary Mediastinal Malignant Germ Cell Tumors: A Retrospective Single-Institution Analysis

2021 ◽  
Vol Volume 13 ◽  
pp. 8527-8534
Author(s):  
Jiaqi Zhang ◽  
Yeye Chen ◽  
Lei Liu ◽  
Mengxin Zhou ◽  
Cheng Huang ◽  
...  



2020 ◽  
Vol 5 (4) ◽  
pp. S45
Author(s):  
Sameer Bakhshi ◽  
Sandeep Agarwala ◽  
Anjan Dhua ◽  
Vishesh Jain ◽  
S. Thulkur ◽  
...  


2020 ◽  
Vol 16 ◽  
pp. S1
Author(s):  
Sandeep Agarwala ◽  
Sameer Bakhshi ◽  
Anjan Dhua ◽  
Vishesh Jain ◽  
S. Thulkar ◽  
...  


1994 ◽  
Vol 5 (3) ◽  
pp. 225-231 ◽  
Author(s):  
J.I. Mayordomo ◽  
L. Paz-Ares ◽  
F. Rivera ◽  
M. López-Brea ◽  
E. López Martín ◽  
...  


2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii333-iii333
Author(s):  
Lei Wen ◽  
Juan Li ◽  
Qingjun Hu ◽  
Mingyao Lai ◽  
Cheng Zhou ◽  
...  

Abstract BACKGROUND Limited data is available in intracranial nongerminomatous germ cell tumors (NGGCTs) in Chinese population. Here we aimed to retrospectively assess the clinical-pathological and prognostic factors of NGGCTs in a single large institution in China. METHODS From June 2003 to December 2018, 111 consecutive NGGCTs were treated in Guangdong Sanjiu Brain Hospital, China. RESULTS The median follow-up was 36.2 months (range, 1.2 to 131.2 months). Three-year EFS and OS for 111 NGGCTs patients were 78.5%±4.5% and 82.8%±4.0%, respectively. 98 patients received CSI plus boost yielded better survival than those who received reduced-volume radiotherapy or no radiotherapy (3y OS, 86.7% vs. 51.4%, p=0.007). Patients had at least four cycles of chemotherapy were strongly associated with improved 3-year OS, compared to those received less than 4 cycles (94.1% vs. 63.6%, p<0.001). There was no significant difference in survival of patients stratified by age, surgery, hydrocephalus, as well as tumor diameter. Multivariate analysis identified chemotherapy cycles less than 4 was the only prognostic factor that conferring a worse OS (p=0.003). Patients both received CSI and at least 4 courses of chemotherapy were correlated with lower incidence of relapse (p=0.044). CONCLUSIONS Multimodal approach including CSI and enough courses of chemotherapy was effective and should be recommended for the treatment of newly diagnosed NGGCTs in Chinese population.



Author(s):  
Lorna A. Fern ◽  
Michelle Greenwood ◽  
Shievon Smith ◽  
Susan Brand ◽  
Nicholas Coleman ◽  
...  




2004 ◽  
Vol 68 (2) ◽  
pp. 153-159 ◽  
Author(s):  
A.A. Smith ◽  
E. Weng ◽  
M. Handler ◽  
N.K. Foreman


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