In vitro Preparation and Evaluation of Sustained-Release Microcapsules of Salvianolic Acid [Retraction]

Abstract The aim of the study was to prepare lansoprazole (LNS)-loaded poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles in order to improve the physicochemical stability associated with LNS. We synthesized LNS-loaded PLGA nanoparticles in the presence of magnesium oxide as alkalizer to improve the release of LNS and stability against photodegradation. The LNS-encapsulated PLGA nanoparticles were developed by the nanoprecipitation/solvent evaporation method, resulting in a particle size of 246.7 ± 3.4 nm, polydispersity index (PDI) of 0.126, percent drug entrapment (PDE) of 82.85 ± 4.5%, percent drug loading (PDL) of 3.54 ± 0.34%, and pH of 8.10 ± 0.56. The developed nanoparticles were further evaluated for in vitro release and resistance to photodegradation by NMR spectroscopy and LC-MS. The sustained release of the drug was confirmed after the encapsulation of LNS in the PLGA matrix. The protection of LNS in the PLGA matrix against photodegradation was confirmed by NMR and LC-MS studies. The LC-MS of UV-exposed samples of pure LNS and LNS-loaded PLGA nanoparticles at 254 nm showed the same (M + 1) peak at 370 m/e, and the base peak at 369 m/e accounted for the unchanged structure of LNS inside PLGA nanoparticles. Overall, it was proved that PLGA nanoparticles in the presence of magnesium oxide are an efficient carrier to deliver and protect LNS from physicochemical instability.

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PREPARATION AND EVALUATION OF IN VITRO DISSOLUTION CHARACTERISTICS OF SUSTAINED RELEASE METOPROLOL TARTRATE MICROCAPSULES

Zagazig Journal of Pharmaceutical Sciences ◽

10.21608/zjps.1997.184960 ◽

1997 ◽

Vol 6 (1) ◽

pp. 99-104

Author(s):

Mohammed El-Sayed

Keyword(s):

Sustained Release ◽

In Vitro Dissolution ◽

Metoprolol Tartrate ◽

Preparation And Evaluation

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Inhalable sustained release rifampicin microparticles: preparation and evaluation of in vitro and in vivo deposition

Journal of Drug Delivery Science and Technology ◽

10.1016/s1773-2247(12)50023-7 ◽

2012 ◽

Vol 22 (2) ◽

pp. 175-179 ◽

Cited By ~ 4

Author(s):

M.A. Darbandi ◽

M. Zandkarimi

Keyword(s):

Sustained Release ◽

Preparation And Evaluation

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Preparation and evaluation of a timolol maleate drug–resin ophthalmic suspension as a sustained-release formulation in vitro and in vivo

Drug Development and Industrial Pharmacy ◽

10.3109/03639045.2015.1085872 ◽

2015 ◽

Vol 42 (4) ◽

pp. 535-545 ◽

Cited By ~ 3

Author(s):

Fuhong Qin ◽

Li Zeng ◽

Yongtao Zhu ◽

Jingjing Cao ◽

Xiaohui Wang ◽

...

Keyword(s):

Sustained Release ◽

Timolol Maleate ◽

Release Formulation ◽

Sustained Release Formulation ◽

Preparation And Evaluation ◽

Ophthalmic Suspension

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Preparation and evaluation of tolmetin sodium conventional and sustained-release suppositories

Scientia Pharmaceutica ◽

10.3797/scipharm.aut-02-09 ◽

2002 ◽

Vol 70 (1) ◽

pp. 77-86

Author(s):

Baloǧlu B. ◽

Kirkaǧaçhoǧlu O.

Keyword(s):

Polyethylene Glycol ◽

Sustained Release ◽

In Vitro Release ◽

Water Soluble ◽

Order Kinetic ◽

Polyethylene Glycol 400 ◽

Suppository Base ◽

Soluble Base ◽

Preparation And Evaluation

Conventional suppositories of tolmetin sodium were prepared by using two different types of Witepsol as an oily base and two different ratios of polyethylene glycol 400: polyethylene glycol 4000 as an water-soluble base. In addition, sustained- release suppositories were prepared by adding Eudragit L-100 ta the suppositories. The effects of the suppository base and the ratios of the polyethylene glycol 400: polyethylene glycols 4000 on the in vitro release characteristics were investigated. The release rate of tolmetin sodium from the conventional suppositories prepared with polyethylene glycol was slower than the other suppositories prepared with Witepsol. All of the suppositories with Eudragit L-100 showed slow-release profiles and the drug release rates clearly depended on the Eudragit L-100 content. When dissolution results were evaluated kinetically, zero order kinetic was observed with the sustained- release suppositories of tolmetin sodium prepared with polyethyleneglycol 400: polyethyleneglycol 4000 by adding Eudragit L-100.

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Preparation and evaluation of novel galantamine hydrobromide sustained-release capsule

Bangladesh Journal of Pharmacology ◽

10.3329/bjp.v11is1.26417 ◽

2016 ◽

Vol 11 ◽

pp. S82-S91 ◽

Cited By ~ 1

Author(s):

Shuoye Yang

Keyword(s):

Sustained Release ◽

In Vitro Release ◽

In Vitro Study ◽

Release Process ◽

Release Formulation ◽

Sustained Release Formulation ◽

Promising Alternative ◽

Release Studies ◽

Preparation And Evaluation

In present study, a novel galantamine hydrobromide sustained-release capsule was prepared with the extrusion-spheronization method and the optimized preparative formulation. The release studies were performed using marketed capsules (Razadyne ER) as a reference and data were analyzed in terms of cumulative release amounts as a function of time. Furthermore, fiber-optic real time detection was adopted to monitor the release process. Results demonstrated that our developed formulation had superior properties, worked better as sustained-release carriers and lasted longer time to release compared with the marketed product. The in vitro release characteristics of different batches of preparations were quite similar with each other, the total release proportions of galantamine hydrobromide from sustained-release capsules reached higher than 90% within 12 hours. Similar factors f2 of two preparations were all higher than 50, the release profile of drugs from capsules fitted to Higuchi model with the equation of Q% = 0.2681t1/2 + 0.0684 (r = 0.9966). Pharmacokinetics profile and parameters in beagle dogs after oral administration also revealed the superior release performances of new capsules being consistent with the in vitro study. The developed sustained-release formulation may be a promising alternative dosage form for treatment of related diseases.

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