scholarly journals Clinical use of cobicistat as a pharmacoenhancer of human immunodeficiency virus therapy

2015 ◽  
pp. 1
Author(s):  
Nils von Hentig
Keyword(s):  
Human Immunodeficiency Virus ◽  
Clinical Use ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Therapy

scholarly journals Pathogenesis of Human Immunodeficiency Virus-Mycobacterium tuberculosis Co-Infection

2020 ◽  
Vol 9 (11) ◽  
pp. 3575
Author(s):  
Kevin Wong ◽  
James Nguyen ◽  
Lillie Blair ◽  
Marina Banjanin ◽  
Bunraj Grewal ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Mycobacterium Tuberculosis ◽  
Opportunistic Infections ◽  
Treatment Options ◽  
Clinical Use ◽  
Hiv Disease ◽  
Adjuvant Therapies ◽  
Tnf Α ◽  
Immunodeficiency Virus ◽  
Living With Hiv

Given that infection with Mycobacterium tuberculosis (Mtb) is the leading cause of death amongst individuals living with HIV, understanding the complex mechanisms by which Mtb exacerbates HIV infection may lead to improved treatment options or adjuvant therapies. While it is well-understood how HIV compromises the immune system and leaves the host vulnerable to opportunistic infections such as Mtb, less is known about the interplay of disease once active Mtb is established. This review explores how glutathione (GSH) depletion, T cell exhaustion, granuloma formation, and TNF-α upregulation, as a result of Mtb infection, leads to an increase in HIV disease severity. This review also examines the difficulties of treating coinfected patients and suggests further research on the clinical use of GSH supplementation.

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