scholarly journals Effect of inserted spacer in hepatic cell-penetrating multifunctional peptide component on the DNA intracellular delivery of quaternary complexes based on modular design

2016 ◽  
Vol Volume 11 ◽  
pp. 6283-6295 ◽  
Author(s):  
Luchen Zhang ◽  
Zhenbo Li ◽  
Fangli Sun ◽  
Yuhong Xu ◽  
Zixiu Du
Keyword(s):  
Modular Design ◽  
Intracellular Delivery ◽  
Hepatic Cell ◽  
Cell Penetrating ◽  
Peptide Component

Complementary leucine zippering system for effective intracellular delivery of proteins by cell-penetrating peptides

2021 ◽  
Vol 33 ◽  
pp. 116036
Author(s):  
Mizuki Kitamatsu ◽  
Hiroki Yuasa ◽  
Takashi Ohtsuki ◽  
Hiroyuki Michiue
Keyword(s):  
Intracellular Delivery ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating

Intracellular Delivery of Oxaliplatin Conjugate via Cell Penetrating Peptide for the Treatment of Colorectal Carcinoma in vitro and in vivo

2021 ◽  
pp. 120904
Author(s):  
Tejinder Singh ◽  
Dong Hyun Kang ◽  
Tae Wan Kim ◽  
Hye Jeong Kong ◽  
Jae Sung Ryu ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Intracellular Delivery ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating

Porous Silicon–Cell Penetrating Peptide Hybrid Nanocarrier for Intracellular Delivery of Oligonucleotides

2013 ◽  
Vol 11 (2) ◽  
pp. 382-390 ◽  
Author(s):  
Jussi Rytkönen ◽  
Piret Arukuusk ◽  
Wujun Xu ◽  
Kaido Kurrikoff ◽  
Ülo Langel ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Intracellular Delivery ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
Silicon Cell

scholarly journals Novel human-derived cell-penetrating peptides for specific subcellular delivery of therapeutic biomolecules

2005 ◽  
Vol 390 (2) ◽  
pp. 407-418 ◽  
Author(s):  
Catherine de Coupade ◽  
Antonio Fittipaldi ◽  
Vanessa Chagnas ◽  
Matthieu Michel ◽  
Sophie Carlier ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Mammalian Cells ◽  
Heparan Sulphate ◽  
Intracellular Delivery ◽  
Membrane Lipid ◽  
Cell Penetrating Peptides ◽  
Heparin Binding ◽  
Independent Manner ◽  
Cell Penetrating

Short peptide sequences that are able to transport molecules across the cell membrane have been developed as tools for intracellular delivery of therapeutic molecules. This work describes a novel family of cell-penetrating peptides named Vectocell® peptides [also termed DPVs (Diatos peptide vectors)]. These peptides, originating from human heparin binding proteins and/or anti-DNA antibodies, once conjugated to a therapeutic molecule, can deliver the molecule to either the cytoplasm or the nucleus of mammalian cells. Vectocell® peptides can drive intracellular delivery of molecules of varying molecular mass, including full-length active immunoglobulins, with efficiency often greater than that of the well-characterized cell-penetrating peptide Tat. The internalization of Vectocell® peptides has been demonstrated to occur in both adherent and suspension cell lines as well as in primary cells through an energy-dependent endocytosis process, involving cell-membrane lipid rafts. This endocytosis occurs after binding of the cell-penetrating peptides to extracellular heparan sulphate proteoglycans, except for one particular peptide (DPV1047) that partially originates from an anti-DNA antibody and is internalized in a caveolar independent manner. These new therapeutic tools are currently being developed for intracellular delivery of a number of active molecules and their potentiality for in vivo transduction investigated.

scholarly journals Titelbild: Intracellular Delivery of Native Proteins Facilitated by Cell-Penetrating Poly(disulfide)s (Angew. Chem. 6/2018)

2018 ◽  
Vol 130 (6) ◽  
pp. 1435-1435
Author(s):  
Linghui Qian ◽  
Jiaqi Fu ◽  
Peiyan Yuan ◽  
Shubo Du ◽  
Wei Huang ◽  
...  
Keyword(s):  
Intracellular Delivery ◽  
Native Proteins ◽  
Cell Penetrating

Variable Heavy Chain Domain Derived from a Cell-Penetrating Anti-DNA Monoclonal Antibody for the Intracellular Delivery of Biomolecules

2017 ◽  
Vol 46 (5) ◽  
pp. 500-517 ◽  
Author(s):  
Sun-Woo Im ◽  
Pavithra Pravinsagar ◽  
Sae-Ran Im ◽  
Young-Ju Jang
Keyword(s):  
Monoclonal Antibody ◽  
Heavy Chain ◽  
Intracellular Delivery ◽  
Cell Penetrating ◽  
Variable Heavy ◽  
A Cell

Cell-penetrating peptides in the intracellular delivery of viral nanoparticles

2021 ◽  
pp. 47-76
Author(s):  
Alžběta Hejtmánková ◽  
Jana Váňová ◽  
Hana Španielová
Keyword(s):  
Intracellular Delivery ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating ◽  
Viral Nanoparticles

Therapeutic delivery using cell-penetrating peptides

2013 ◽  
Vol 5 (3) ◽  
Author(s):  
Rupa R. Sawant ◽  
Niravkumar R. Patel ◽  
Vladimir P. Torchilin
Keyword(s):  
Small Molecules ◽  
Therapeutic Agent ◽  
Intracellular Delivery ◽  
Cell Penetrating Peptides ◽  
Current Status ◽  
Unique Challenge ◽  
Large Molecules ◽  
Therapeutic Delivery ◽  
Cell Penetrating ◽  
Stimuli Sensitive

AbstractIntracellular delivery of promising therapeutic agents as well as nanocarriers presents a unique challenge. However, with the discovery of the cell-penetrating peptides (CPPs), overcoming this obstacle seems more plausible. In many cases, CPPs conjugated with therapeutic agent or therapeutic agent loaded-nanoparticles have shown promising results via increased cellular uptake. In this review, the current status of CPPs for the intracellular delivery of not just potential therapeutic small molecules but also large molecules like peptides, nucleic acids and nanocarriers is discussed. In addition, the design of ‘smart stimuli-sensitive nanocarrier’ to overcome the non-target-specificity of CPPs is also described.

scholarly journals Codelivery of a cytotoxin and photosensitiser via a liposomal nanocarrier: a novel strategy for light-triggered cytosolic release

Nanoscale ◽  
2018 ◽  
Vol 10 (43) ◽  
pp. 20366-20376 ◽  
Author(s):  
Elnaz Yaghini ◽  
Ruggero Dondi ◽  
Karen J. Edler ◽  
Marilena Loizidou ◽  
Alexander J. MacRobert ◽  
...  
Keyword(s):  
Intracellular Delivery ◽  
Cell Penetrating Peptide ◽  
Protein Toxin ◽  
Cell Penetrating ◽  
A Cell ◽  
Novel Strategy

Light-triggered intracellular delivery of a protein toxin was achieved by codelivery via a liposomal nanocarrier, targeted with a cell-penetrating peptide (CPP)–photosensitiser conjugate.

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