Reduction of central neuropathic pain with ketamine infusion in a patient with Ehlers–Danlos syndrome: a case report

Chronic neuropathic pain and depression are often comorbid. Ketamine has been used to treat refractory pain. There is emerging evidence for use in depression. We present a case of a pediatric patient who was successfully treated with subanesthetic intravenous ketamine infusion for chronic neuropathic pain and suicidality.

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Treatment of an acute severe central neuropathic pain syndrome by topical application of lidocaine 5% patch: a case report

Spinal Cord ◽

10.1038/sj.sc.3102098 ◽

2007 ◽

Vol 46 (4) ◽

pp. 311-313 ◽

Cited By ~ 14

Author(s):

G H Hans ◽

D N Robert ◽

K N Van Maldeghem

Keyword(s):

Neuropathic Pain ◽

Case Report ◽

Topical Application ◽

Pain Syndrome ◽

Neuropathic Pain Syndrome ◽

Central Neuropathic Pain

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373 CASE REPORT OF A 56 YEAR OLD MALE PATIENT WITH CENTRAL NEUROPATHIC PAIN TREATED WITH INTRATHECAL DRUG DELIVERY

European Journal of Pain Supplements ◽

10.1016/s1754-3207(10)70378-3 ◽

2010 ◽

Vol 4 (S1) ◽

pp. 106-106

Author(s):

A. Tzortzopoulou ◽

A. Kolotoura ◽

A. Alexandropoulou ◽

G. Provataki ◽

E. Anastasiou ◽

...

Keyword(s):

Drug Delivery ◽

Neuropathic Pain ◽

Case Report ◽

Male Patient ◽

Central Neuropathic Pain ◽

Intrathecal Drug Delivery

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Multimodal Stepped Care Approach with Acupuncture and Ppar-α Agonist Palmitoylethanolamide in the Treatment of a Patient with Multiple Sclerosis and Central Neuropathic Pain

Acupuncture in Medicine ◽

10.1136/acupmed-2011-010119 ◽

2012 ◽

Vol 30 (1) ◽

pp. 53-55 ◽

Cited By ~ 24

Author(s):

David J Kopsky ◽

Jan M Keppel Hesselink

Keyword(s):

Multiple Sclerosis ◽

Neuropathic Pain ◽

Case Report ◽

Natural Compound ◽

Stepped Care ◽

Peroxisome Proliferator ◽

Key Factors ◽

Peroxisome Proliferator Activated Receptor ◽

Central Neuropathic Pain ◽

Care Approach

Central neuropathic pain is a common debilitating symptom in patients with multiple sclerosis. Side effects of analgesics often limit reaching therapeutic dosages. In this case report, a 61-year-old woman with chronic central neuropathic pain due to multiple sclerosis is described. Acupuncture could only partly and temporarily reduce the pain. However, after adding the natural compound palmitoylethanolamide, a glial modulator and peroxisome proliferator-activated receptor-α agonist, pain reduction was more pronounced and the interval between acupuncture sessions could be increased. A multimodal stepped care approach is demonstrated, with acupuncture and palmitoylethanolamide both influencing non-neuronal cells, such as activated glial cells, which are key factors in the development and maintenance of neuropathic pain.

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