Clinical Characteristics and Management of Cerebral Venous Sinus Thrombosis in Patients with Essential Thrombocythemia

Sinus Thrombosis ◽

Chloride Ion ◽

Venous Sinus ◽

Venous Sinus Thrombosis ◽

Younger Age ◽

Headache Patients ◽

New Onset

Abstract Objective : This study aimed to assess the clinical characteristics of cerebral venous sinus thrombosis (CVT) patients with new-onset headache and to identify the risk factors for headache in this population.Methods : We retrospectively reviewed the demographic and clinical data of 69 CVT patients recruited between September 2017 and September 2019. Patients were classified into two groups, the headache group and the non-headache group, according to the presence or absence of new-onset headache symptoms at admission. The following characteristics and parameters were measured and analyzed, including gender, age, Diseased sinus amount(DSA), and so on.Results : The incidence of headache was 75% in this cohort. The proportion of female patients in the headache group was higher than that in the non-headache group. Patients in the headache group were younger than those without headache. CVT patients of headache group showed higher LR, BUN, and (ICP)compared to the non-headache group, whereas MCV and levels of protein (CSF) and LDH (CSF) were lower in headache patients. The data also revealed younger age and the increased level of chloride ion CL - (CSF) were the risk factors for the occurrence of headache in CVT patients.Conclusions: The age, LR, MCV, BUN levels, ICP, protein (CSF), and LDH (CSF) in patients with headache were significantly different from those in the non-headache group at admission. Younger age and a level of CL - (CSF) were risk factors for headache in CVT patients. These findings may provide guidance for clinical diagnosis and treatment of CVT.

Clinical characteristics of cerebral venous sinus thrombosis

Neurosciences ◽

10.17712/nsj.2015.3.20140625 ◽

2015 ◽

Vol 20 (3) ◽

pp. 292-295 ◽

Cited By ~ 8

Author(s):

Jia-Wei Wang ◽

Jin-Ping Li ◽

Ying-Lun Song ◽

Ke Tan ◽

Yu Wang ◽

...

Keyword(s):

Sinus Thrombosis ◽

Venous Sinus ◽

Clinical Characteristics of Cerebral Venous Sinus Thrombosis in Patients with Systemic Lupus Erythematosus: A Single-Centre Experience in China

Journal of Immunology Research ◽

10.1155/2015/540738 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 11

Author(s):

Li Wang ◽

Hua Chen ◽

Yao Zhang ◽

Wanli Liu ◽

Wenjie Zheng ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Sinus Thrombosis ◽

Venous Sinus ◽

Clinical Feature ◽

Systemic Lupus ◽

Single Centre ◽

Clinical characteristics of systemic lupus erythematosus (SLE) patients complicated with cerebral venous sinus thrombosis (CVST) between 2000 and 2013 were analyzed through this retrospective, single-centre study. Of 4747 hospitalized SLE patients, 17 (0.36%, 12 females, average age 30) had CVST. Headache (88.2%) was the most common neurological symptom followed by nausea or vomiting (47.1%), conscious disturbance (41.2%), edema of eyelids or conjunctiva (35.3%), blurred vision or diplopia (35.3%), and seizure (35.3%). Increased intracranial pressure (ICP) occurred in 13 cases (76.5%). Magnetic resonance venography (MRV) detected thrombosis in the transverse (82.4%), sigmoid (52.9%), and sagittal (35.3%) sinuses, with frequent (70.6%) multiple sinus occlusions. Compared to SLE patients without CVST, SLE patients with CVST had a higher prevalence of thrombocytopenia and positive antiphospholipid antibodies and a higher SLE disease activity index (SLEDAI) score. 13 patients achieved improvement following glucocorticoids and immunosuppressants treatment, as well as anticoagulants, while 3 patients died at the hospital. CVST is relatively rare in SLE and tends to occur in active lupus patients. Intracranial hypertension is common but nonspecific clinical feature, so MRV evaluation is necessary to establish a diagnosis. Aggressive treatment for the rapid control of SLE activity combined with anticoagulants can improve the prognosis.

JAK2V617F Mutation-positive Childhood Essential Thrombocythemia Associated With Cerebral Venous Sinus Thrombosis

Journal of Pediatric Hematology/Oncology ◽

10.1097/mph.0b013e3181b1ec9e ◽

2009 ◽

Vol 31 (9) ◽

pp. 678-680 ◽

Cited By ~ 5

Author(s):

Hidemitsu Kurosawa ◽

Mayuko Okuya ◽

Takashi Matsushita ◽

Takeo Kubota ◽

Kazushi Endoh ◽

...

Keyword(s):

Essential Thrombocythemia ◽

Sinus Thrombosis ◽

Venous Sinus ◽

Jak2v617f Mutation ◽

Cerebral Venous Sinus Thrombosis as the First Manifestation of JAK2V617F-positive Essential Thrombocythemia

Chinese Medical Journal ◽

10.4103/0366-6999.226903 ◽

2018 ◽

Vol 131 (6) ◽

pp. 748-750 ◽

Cited By ~ 2

Author(s):

Wei-Bi Chen ◽

Xian-Ling Wang

Keyword(s):

Essential Thrombocythemia ◽

Sinus Thrombosis ◽

Venous Sinus ◽

Clinical Characteristics and Management of Cerebral Venous Sinus Thrombosis in Patients With Antiphospholipid Syndrome: A Single-Center Retrospective Study

Clinical and Applied Thrombosis/Hemostasis ◽

10.1177/1076029621999104 ◽

2021 ◽

Vol 27 ◽

pp. 107602962199910

Author(s):

Huixin Shen ◽

Xiaoqin Huang ◽

Chunqiu Fan

Keyword(s):

Antiphospholipid Syndrome ◽

Endovascular Therapy ◽

Sinus Thrombosis ◽

Transverse Sinus ◽

Good Prognosis ◽

Venous Sinus ◽

Initial Manifestation ◽

Antiphospholipid syndrome (APS) with cerebral venous sinus thrombosis (CVST) is a relatively rare phenomenon, and this observational study aimed to investigate the clinical characteristics of APS patients complicated with CVST. We retrospectively investigated the clinical characteristics of CVST events in APS and compared differential characteristics and associated factors between APS patients with and without CVST. Twenty-one CVST patients with APS were enrolled including 14 females (9.4%) and 7 males (5.8%). The median age and disease duration at onset of CVST was 33 years (IQR 28-48) old and 1.3 months (IQR 0.7-4), respectively. Among APS patients with CVST, 12 (57.1%) cases presented with neurologic symptoms of CVST as the initial manifestation. Onset of CVST was mainly chronic (52.4%). Headache (90.5%) was the most common neurological symptom. The common locations of CVST were transverse sinus (76.2%) and superior sagittal sinus (57.1%), with more frequently (76.2%) dual or multiple sinuses involved. All patients with CVST were treated with anticoagulant, and 5 (23.8%) patients received endovascular therapy. Sixteen (84.2%) patients had good outcomes and 3 (15.8%) patients died at last follow-up. There were no significant differences ( P > 0.05) between two groups in the analysis of related APS indicators. There were no significant differences ( P > 0.05) between two groups in the analysis of related APS indicators. Although APS complicated with CVST is rare and predominately chronic developed. The evaluation of CVST should be performed for APS patients with intracranial hypertension syndrome. The routine screening of antiphospholipid antibodies (aPLs) is highly recommended in unexplained CVST patients. Most CVST patients with APS will have a good prognosis after treatment, and endovascular therapy is an alternative treatment.