scholarly journals Update on the role of trabectedin in the treatment of intractable soft tissue sarcomas

2017 ◽  
Vol Volume 10 ◽  
pp. 1155-1164 ◽  
Author(s):  
Federica Recine ◽  
Alberto Bongiovanni ◽  
Nada Riva ◽  
Valentina Fausti ◽  
Alessandro De Vita ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas

Role of New Chemotherapy Agents in Soft Tissue Sarcoma

2005 ◽  
Vol 3 (2) ◽  
pp. 198-205
Author(s):  
Margaret von Mehren
Keyword(s):  
Soft Tissue ◽  
Single Agent ◽  
Growth Factor Receptor ◽  
Soft Tissue Sarcomas ◽  
Serine Threonine Kinase ◽  
Threonine Kinase ◽  
Cell Cycle Activation ◽  
Metastatic Gist ◽  
Chemotherapy Agents

Medical management of soft tissue sarcomas (STS) has been restricted by the limited availability of active drugs. A plethora of new oncologic agents are now available, many of which have specific therapeutic targets. Gemcitabine and docetaxel is a combination of drugs that have limited single-agent activity. Yondelis, a novel chemotherapeutic that binds DNA and functions partially by inhibiting transcription, is being tested alone and in combination with doxorubicin. Inhibitors of mTOR, a serine/threonine kinase that regulates cell cycle activation and cell growth, are also being tested. Growth factor receptor inhibitors are being evaluated in a variety of sarcomas that have been found to express the targets. In addition, a variety of agents are being assessed in gastrointestinal stromal tumors (GIST). Single agents and agents combined with imatinib are being tested in imatinib-refractory and in metastatic GIST. The increased use of targeted agents underscores the need for understanding sarcoma biology.

The role of surgery and radiotherapy in treatment of soft tissue sarcomas of the head and neck region: Review of 30 cases

2009 ◽  
Vol 37 (1) ◽  
pp. 42-48 ◽  
Author(s):  
Merdan Fayda ◽  
Gorkem Aksu ◽  
Fulya Yaman Agaoglu ◽  
Ahmet Karadeniz ◽  
Emin Darendeliler ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Head And Neck ◽  
Soft Tissue Sarcomas ◽  
Neck Region ◽  
Head And Neck Region

The role of ifosfamide in paediatric soft tissue sarcomas

1986 ◽  
Vol 18 (S2) ◽  
pp. S23-S24 ◽  
Author(s):  
J. de Kraker ◽  
P. A. Voûte
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas

The role of pazopanib in various histologic subtypes of metastatic soft tissue sarcomas.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 10586-10586
Author(s):  
Kwai Han Yoo ◽  
Seung Tae Kim ◽  
Jeeyun Lee ◽  
Se Hoon Park ◽  
Sung Joo Kim ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Histologic Subtypes

Role of chemotherapy in the management of soft tissue sarcomas

2010 ◽  
Vol 10 (2) ◽  
pp. 249-260 ◽  
Author(s):  
Dimitrios Krikelis ◽  
Ian Judson
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas
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