scholarly journals ALK-rearrangement neuroendocrine carcinoma of the lung: a comprehensive study of a rare case series and review of literature

2018 ◽  
Vol Volume 11 ◽  
pp. 4991-4998 ◽  
Author(s):  
Qiang Zheng ◽  
Mingjia Zheng ◽  
Yan Jin ◽  
Xuxia Shen ◽  
Ling Shan ◽  
...  
Author(s):  
Cheungsoo Ha ◽  
Yun Kyung Kang ◽  
Joong Won Ha ◽  
Dong Hun Han ◽  
Jun-Ku Lee ◽  
...  

Schwannomas, the most frequently occurring benign tumors of the peripheral nerve sheath, generally remain as painless swellings for several years before diagnosis. Multiple schwannomas involving different nerves within the same extremity are rare. We report a rare case of a 61-year-old female who presented with multiple schwannomas in the palmar common and proper digital nerves, 15 years after the resection of a median nerve schwannoma within the same upper extremity. Using preestablished diagnostic criteria, she was diagnosed with segmental schwannomatosis. After careful surgical resection, biopsy confirmed the diagnosis and she recovered without neurological symptoms or limitations in the range of motion. Literature review revealed only four case series on segmental schwannomatosis, indicating its rarity. Postoperative sensory deficits are more likely in cases with multiple schwannomas in the common and proper digital nerves. We demonstrate that such complications can be avoided by meticulous dissection and separation of the tumors from the nerve fibers.


2013 ◽  
Vol 4 (2) ◽  
pp. 47-50
Author(s):  
Amit Gupta ◽  
Ashutosh Tandon ◽  
Abhay Kumar ◽  
Sunil Kumar ◽  
Usha Rani Singh

Large cell neuroendocrine carcinoma of lung is not one of the commoner varieties of neoplasia found in the lungs. There are around 100 cases in literature which suggest the metastasis of various kinds of lung carcinomas to gastro intestinal tract (GIT). Metastasis of large cell neuroendocrine carcinoma to small bowel is rare. This is a rare case in which the primary neuroendocrine carcinoma of lung presented with metastasis and perforation of small bowel.DOI: http://dx.doi.org/10.3126/ajms.v4i2.5370Asian Journal of Medical Sciences 4(2013) 47-50


2019 ◽  
Vol 62 ◽  
pp. 115-119
Author(s):  
Ikram Chaudhry ◽  
Thabet Algazal ◽  
Ahsan Cheema ◽  
Aman Al Faraj ◽  
Noor Al Malki ◽  
...  

2010 ◽  
Vol 1 (2) ◽  
pp. 99-102 ◽  
Author(s):  
Duncan F Hanby ◽  
Andrew McWhorter ◽  
Eric Wallace ◽  
Eugene A Woltering ◽  
Anthony Harton ◽  
...  

Abstract Objective To describe three patients with nonsinonasal neuroendocrine carcinoma (NSNEC) of the head and neck and present a systematic review of literature. Study design Retrospective chart review Methods Three patients with pathologically proven NSNEC of the head-neck who presented to our institution were identified. Relevant demographic, clinic-pathological, and radiological data was recorded. A web-based search was conducted to identify relevant scientific literature on “neuroendocrine carcinoma (NEC) of the head and neck” and a systematic review of literature is presented. Results Two female and one male patient aged 44 to 66 years presented to our service with NEC of the supraglottis (2/3), and of the thymus (1/3). Diagnosis was confirmed with immunohistochemical staining such as Ki-67, synaptophysin, chromogranin, and also with octreotide scanning. The first case, a T4bN0M0 large cell NEC of the thymus with tracheal invasion received conservative airway management and emergent radiotherapy. The second case, moderately differentiated NEC of the supraglottis was managed with a laser supraglottic laryngectomy followed by adjuvant treatment. The third case, a laryngeal NEC was treated with chemoradiotherapy. Conclusions NSNEC of the head and neck are extremely rare tumors with variability in clinical presentation that present challenges in diagnosis and treatment planning. Consideration of the histological subtype and staining characteristics of the individual tumor, accurate diagnosis, and classification of the tumor is vital in order to tailor therapeutic intervention.


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