scholarly journals Acute Myeloid Leukemia with NUP98-RARG Gene Fusion Similar to Acute Promyelocytic Leukemia: Case Report and Literature Review

2020 ◽  
Vol Volume 13 ◽  
pp. 10559-10566
Author(s):  
Shandong Tao ◽  
Lixiao Song ◽  
Yuan Deng ◽  
Yue Chen ◽  
Yuye Shi ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Literature Review ◽  
Acute Promyelocytic Leukemia ◽  
Myeloid Leukemia ◽  
Gene Fusion ◽  
Promyelocytic Leukemia ◽  
Em Gene ◽  
Acute Myeloid

Therapy-related acute myeloid leukemia with t(9;11)(p12;q23) in a patient treated for acute promyelocytic leukemia

2003 ◽  
Vol 4 (4) ◽  
pp. 289-291 ◽  
Author(s):  
Mario Annunziata ◽  
Salvatore Palmieri ◽  
Barbara Pocali ◽  
Mariacarla De Simone ◽  
Luigi Del Vecchio ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Acute Promyelocytic Leukemia ◽  
Myeloid Leukemia ◽  
Promyelocytic Leukemia ◽  
Acute Myeloid

scholarly journals Acute myeloid leukemia with CPSF6–RARG fusion resembling acute promyelocytic leukemia with extramedullary infiltration

2021 ◽  
Vol 12 ◽  
pp. 204062072097698
Author(s):  
Xiaoyan Han ◽  
Chunxiang Jin ◽  
Gaofeng Zheng ◽  
Yi Li ◽  
Yungui Wang ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Retinoic Acid ◽  
Acute Promyelocytic Leukemia ◽  
Myeloid Leukemia ◽  
Retinoic Acid Receptor ◽  
Promyelocytic Leukemia ◽  
Specific Factor ◽  
Acid Receptor ◽  
Response To Chemotherapy ◽  
Acute Myeloid

Some subtypes of acute myeloid leukemia (AML) share morphologic, immunophenotypic, and clinical features of acute promyelocytic leukemia (APL), but lack a PML–RARA (promyelocytic leukemia–retinoic acid receptor alpha) fusion gene. Instead, they have the retinoic acid receptor beta (RARB) or retinoic acid receptor gamma (RARG) rearranged. Almost all of these AML subtypes exhibit resistance to all-trans retinoic acid (ATRA); undoubtedly, the prognosis is poor. Here, we present an AML patient resembling APL with a novel cleavage and polyadenylation specific factor 6 ( CPSF6) –RARG fusion, showing resistance to ATRA and poor response to chemotherapy with homoharringtonine and cytarabine. Simultaneously, the patient also had extramedullary infiltration.

scholarly journals Acute myeloid leukemia with t(7;21)(p22;q22) and 5q deletion: a case report and literature review

2014 ◽  
Vol 3 (1) ◽  
pp. 8 ◽  
Author(s):  
Jianling Ji ◽  
Eric Loo ◽  
Sheeja Pullarkat ◽  
Lynn Yang ◽  
Carlos A Tirado
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Literature Review ◽  
Myeloid Leukemia ◽  
5Q Deletion ◽  
Acute Myeloid

Acute myeloid leukemia with mutated NPM1 mimics acute promyelocytic leukemia presentation

2020 ◽  
Author(s):  
Manuel J. Arana Rosainz ◽  
Nghia Nguyen ◽  
Amer Wahed ◽  
Laura C. Lelenwa ◽  
Nfn Aakash ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Acute Promyelocytic Leukemia ◽  
Myeloid Leukemia ◽  
Promyelocytic Leukemia ◽  
Acute Myeloid

scholarly journals Ocular Granulocytic Sarcoma: A Case Report and Literature Review of Ocular Extramedullary Acute Myeloid Leukemia

2013 ◽  
Vol 13 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Maro Ohanian ◽  
Gautam Borthakur ◽  
Alfonso Quintas-Cardama ◽  
Michael Mathisen ◽  
Jorge E. Cortés ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Literature Review ◽  
Myeloid Leukemia ◽  
Granulocytic Sarcoma ◽  
Acute Myeloid

scholarly journals ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression

Blood ◽  
2006 ◽  
Vol 107 (8) ◽  
pp. 3330-3338 ◽  
Author(s):  
Beatrice U. Mueller ◽  
Thomas Pabst ◽  
José Fos ◽  
Vibor Petkovic ◽  
Martin F. Fey ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Retinoic Acid ◽  
Acute Promyelocytic Leukemia ◽  
Myeloid Leukemia ◽  
Retinoic Acid Receptor ◽  
Promyelocytic Leukemia ◽  
All Trans Retinoic Acid ◽  
Conditional Expression ◽  
Neutrophil Differentiation ◽  
Acute Myeloid

Abstract Tightly regulated expression of the transcription factor PU.1 is crucial for normal hematopoiesis. PU.1 knockdown mice develop acute myeloid leukemia (AML), and PU.1 mutations have been observed in some populations of patients with AML. Here we found that conditional expression of promyelocytic leukemia-retinoic acid receptor α (PML-RARA), the protein encoded by the t(15;17) translocation found in acute promyelocytic leukemia (APL), suppressed PU.1 expression, while treatment of APL cell lines and primary cells with all-trans retinoic acid (ATRA) restored PU.1 expression and induced neutrophil differentiation. ATRA-induced activation was mediated by a region in the PU.1 promoter to which CEBPB and OCT-1 binding were induced. Finally, conditional expression of PU.1 in human APL cells was sufficient to trigger neutrophil differentiation, whereas reduction of PU.1 by small interfering RNA (siRNA) blocked ATRA-induced neutrophil differentiation. This is the first report to show that PU.1 is suppressed in acute promyelocytic leukemia, and that ATRA restores PU.1 expression in cells harboring t(15;17).

scholarly journals Comment on Geoffroy, M.-C.; de Thé H. Classic and Variants APLs, as Viewed from a Therapy Response. Cancers 2020, 12, 967

Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 5883
Author(s):  
Zhan Su ◽  
Xin Liu
Keyword(s):  
Acute Myeloid Leukemia ◽  
Acute Promyelocytic Leukemia ◽  
Myeloid Leukemia ◽  
Therapy Response ◽  
Promyelocytic Leukemia ◽  
Acute Myeloid

Acute promyelocytic leukemia (APL) is a unique and very deeply studied acute myeloid leukemia [...]

Sign in / Sign up

Export Citation Format

Share Document