Microvascular Changes in Macular Area After Phacoemulsification and Its Influencing Factors Assessed by Optical Coherence Tomography Angiography

Purpose We aimed to evaluate microvascular changes on optical coherence tomography angiography (OCTA) in patients with rhegmatogenous retinal detachment (RRD) who underwent silicone oil (SO) tamponade and compare changes according to macular involvement. Methods This retrospective study included 48 patients with unilateral RRD who underwent vitrectomy and SO tamponade and were stable after SO removal. Control data were obtained from the fellow healthy eye. Ophthalmic examinations, including best corrective visual acuity (BCVA) and OCTA, were conducted. Differences in vascular density (VD) in different sections of the macula and differences in the foveal avascular zone (FAZ) were analyzed between the affected eyes and control eyes. Subgroup analyses according to macular involvement were performed. Results Baseline BCVA and duration of SO tamponade were associated with postoperative BCVA (p<0.001, p = 0.03, respectively). The average VD in the deep capillary plexus (DCP) and the VD of the nasal parafoveal area in both the superficial capillary plexus (SCP) and the DCP decreased relative to those in the control eyes (p = 0.026, p = 0.028, and p = 0.031, respectively). The FAZ area in the DCP and in the SCP also increased when compared with that in the controls (p = 0.043, p = 0.002, respectively). In addition, the macular-off RRD group had lower VD in the nasal parafoveal area of the DCP than the macular-on RRD group. Conclusion SO tamponade could cause microvascular changes, especially in the nasal parafoveal area. The macular-off RRD group were affected more than the macular-on RRD group.

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Microvascular changes in amblyopic eyes detected by optical coherence tomography angiography

Journal of American Association for Pediatric Ophthalmology and Strabismus ◽

10.1016/j.jaapos.2018.12.009 ◽

2019 ◽

Vol 23 (3) ◽

pp. 155.e1-155.e4 ◽

Cited By ~ 2

Author(s):

Mujdat Karabulut ◽

Sinem Karabulut ◽

Sabahattin Sül ◽

Aylin Karalezli

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Optical Coherence ◽

Microvascular Changes

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Quantitative assessment of macular and peripapillary microvasculature using optical coherence tomography angiography in glaucomatous versus healthy eyes

QJM ◽

10.1093/qjmed/hcab109.001 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Amr M Sanad ◽

Mohamed M Mahgoub ◽

Weam M Ebeid ◽

Rabab A Mahmoud

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Vessel Density ◽

Optical Coherence ◽

Open Angle ◽

University Hospitals ◽

Microvascular Changes ◽

Group 2

Abstract Background Glaucoma is the leading cause of irreversible blindness worldwide. With the growing burden of glaucoma, we looked for better tools for early diagnosis and monitoring. Aim of the Work using optical coherence tomography angiography (OCTA) vessel density (VD) to document, quantify and compare microvasculature changes in macula and peripapillary region between healthy and moderate to severe primary open angle glaucoma eyes. Patients and Methods A comparative interventional prospective study was conducted on 28 eyes of 14 subjects, recruited from Ain Shams University hospitals outpatient clinic, and were subjected to imaging procedure during the period from January 2020 to May 2020. Subjects were divided into two groups: Group 1 of 14 eyes of 9 patients with moderate to severe primary open angle glaucoma (POAG), and group 2 of 14 eyes of 7 healthy sex and age-matched controls. Results a statistically significant decrease was found in VD in the peripapillary region (P < 0.001) and superficial macular regions in glaucoma subjects (P < 0.001). Conclusion OCTA proved a quantitative decrease in both peripapillary and macular vessel density as a parameter of microvascular changes associated with moderate to severe POAG. These results reflect damage to tissues relevant to the pathophysiology of POAG demonstrating OCTA importance with respect to diagnosing glaucoma and understanding the pathophysiology of this disease and, guiding future studies to evaluate more potential uses of this technology in the actual assessment of patients with glaucoma.

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