scholarly journals Study Of Circulating Levels Of Mir-126 And Vascular Complication In End Stage Renal Disease Patients On Heamodialysis

2021 ◽  
Vol 2 (2) ◽  
pp. 75-87
Author(s):  
Keroles Ata Rofaiel Bebawi ◽  
Heba Hamdy Mahmoud ◽  
Ahmed Sayed Abd Elbasset
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Vascular Complication ◽  
Stage Renal Disease ◽  
End Stage ◽  
Circulating Levels

scholarly journals In Vivo Shear Stress Determines Circulating Levels of Endothelial Microparticles in End-Stage Renal Disease

Hypertension ◽  
2007 ◽  
Vol 49 (4) ◽  
pp. 902-908 ◽  
Author(s):  
Chantal M. Boulanger ◽  
Nicolas Amabile ◽  
Alain P. Guérin ◽  
Bruno Pannier ◽  
Aurélie S. Leroyer ◽  
...  
Keyword(s):  
Shear Stress ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Endothelial Microparticles ◽  
Stage Renal Disease ◽  
End Stage ◽  
Circulating Levels

A translational approach to micro-inflammation in end-stage renal disease: molecular effects of low levels of interleukin-6

2010 ◽  
Vol 119 (4) ◽  
pp. 163-174 ◽  
Author(s):  
Bruno Memoli ◽  
Simona Salerno ◽  
Alfredo Procino ◽  
Loredana Postiglione ◽  
Sabrina Morelli ◽  
...  
Keyword(s):  
Gene Expression ◽  
Renal Disease ◽  
Interleukin 6 ◽  
End Stage Renal Disease ◽  
Human Hepatocytes ◽  
Fetuin A ◽  
Stage Renal Disease ◽  
End Stage ◽  
Circulating Levels ◽  
Esrd Patients

Inflammation plays a key role in the progression of cardiovascular disease, the leading cause of mortality in ESRD (end-stage renal disease). Over recent years, inflammation has been greatly reduced with treatment, but mortality remains high. The aim of the present study was to assess whether low (<2 pg/ml) circulating levels of IL-6 (interleukin-6) are necessary and sufficient to activate the transcription factor STAT3 (signal transducer and activator of transcription 3) in human hepatocytes, and if this micro-inflammatory state was associated with changes in gene expression of some acute-phase proteins involved in cardiovascular mortality in ESRD. Human hepatocytes were treated for 24 h in the presence and absence of serum fractions from ESRD patients and healthy subjects with different concentrations of IL-6. The specific role of the cytokine was also evaluated by cell experiments with serum containing blocked IL-6. Furthermore, a comparison of the effects of IL-6 from patient serum and rIL-6 (recombinant IL-6) at increasing concentrations was performed. Confocal microscopy and Western blotting demonstrated that STAT3 activation was associated with IL-6 cell-membrane-bound receptor overexpression only in hepatocytes cultured with 1.8 pg/ml serum IL-6. A linear activation of STAT3 and IL-6 receptor expression was also observed after incubation with rIL-6. Treatment of hepatocytes with 1.8 pg/ml serum IL-6 was also associated with a 31.6-fold up-regulation of hepcidin gene expression and a 8.9-fold down-regulation of fetuin-A gene expression. In conclusion, these results demonstrated that low (<2 pg/ml) circulating levels of IL-6, as present in non-inflamed ESRD patients, are sufficient to activate some inflammatory pathways and can differentially regulate hepcidin and fetuin-A gene expression.

scholarly journals Circulating levels of inflammation-associated miR-155 and endothelial-enriched miR-126 in patients with end-stage renal disease

2012 ◽  
Vol 45 (12) ◽  
pp. 1308-1314 ◽  
Author(s):  
Honglei Wang ◽  
Wujian Peng ◽  
Xuemei Shen ◽  
Yunhui Huang ◽  
Xin Ouyang ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Stage Renal Disease ◽  
End Stage ◽  
Circulating Levels

Parathyroid Dysfunction in End Stage Renal Disease

1980 ◽  
Vol 13 (1) ◽  
pp. 193-201
Author(s):  
Philip J. DìTella ◽  
Gordon R. Lang
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Parathyroid Dysfunction ◽  
Stage Renal Disease ◽  
End Stage
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