Relation between Red cell distribution width and Early Atherosclerosis in patients with Beta Thalassemia

Background: The two most frequent types of microcytic hypochromic anemia in developing countries are beta thalassemia trait (𝛽-TT) and iron deficiency anemia (IDA). Several indices using blood cell count parameters have been suggested to differentiate between two. In this study we evaluated the reliability of three indices.Methods: The present cross-sectional study was carried out in 300 pregnant females in third trimester. Out of these, 90 microcytic hypochromic females were selected. Mentzers index, red cell distribution width index and Matos and Carvalho index (MCI) were calculated from the regular 3-part analyser haematological parameters. Results: The Mentzer index was the most reliable index, as it had the highest sensitivity (97.62%), specificity (66.67%), and Youden’s index (64%) for detecting Iron deficiency anaemia; the Matos and Carvalho Index showed higher sensitivity (98.81%)but a much lower specificity (33.3%) and Youden’s index (32%) while the red cell distribution width index showed the sensitivity and specificity of 92.86% and 66.67%, respectively with Youden’s index of 59%.Conclusions: The Mentzer index provided the highest reliabilities for differentiating IDA from 𝛽-TT. The new indices have high sensitivities and positive predictive value for identifying IDA, making them useful for screening population at risk.

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The value of the red cell distribution width index versus other parameters in the differentiation between iron deficiency anemia and beta thalassemia trait among children in Mosul, Iraq

Expert Review of Hematology ◽

10.1080/17474086.2021.1905514 ◽

2021 ◽

Author(s):

Aws H. Al-Numan ◽

Riyadh A. Al-Obeidi

Keyword(s):

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Red Cell Distribution Width ◽

Deficiency Anemia ◽

Beta Thalassemia ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

Thalassemia Trait

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DIAGNOSTIC EFFICACY OF RED BLOOD CELL INDICES IN DIAGNOSIS OF BETA THALASSEMIA TRAIT TAKING HAEMOGLOBIN ELECTROPHORESIS AS GOLD STANDARD

Pakistan Armed Forces Medical Journal ◽

10.51253/pafmj.v71i3.3905 ◽

2021 ◽

Vol 71 (3) ◽

pp. 1006-10

Author(s):

Sahar Rabbani ◽

Muhammad Farooq ◽

Samina Naeem ◽

Nasir Uddin ◽

Muhammad Abdul Naeem ◽

...

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Red Cell Distribution Width ◽

Beta Thalassemia ◽

Red Cell ◽

Cell Distribution ◽

Diagnostic Efficacy ◽

Mean Cell Volume ◽

Distribution Width ◽

Thalassemia Trait

Objective: To determine the diagnostic efficacy of haematological indices for the diagnosis of beta thalassemia trait taking haemoglobin electrophoresis as a gold standard. Study Design: Cross sectional study. Place and Duration of Study: Department of Haematology Combined Military Hospital Lahore, from Aug to Dec 2019. Methodology: Two hundred and six anaemic patients 20-70 years of age of both genders were included in the study. Blood was collected from all the patients and complete blood count were generated through automated haematology analyser Sysmex KX-21. Based on the complete blood count parameters like mean cell volume, red blood cell count, red cell distribution width and mean cell haemoglobinthe haematological indices such as Mentzer, Ricerca, mean density of Hb/litre of blood, mean cell Hb density and red cell distributon width indices were calculated. The haemoglobin A2 band of >3.5% on haemoglobin electrophoresis was taken as cut off for Beta thalassemia trait. Results: Out of the 206 blood samples analysed, 120 (58%) were labelled as Beta thalassemia trait after Hb electrophoresis and 86 cases had anemia due to other causes. Mentzer index established the highest sensitivity of 92.5% whereas RICERCA index established the highest specificity of 94.1%. Mentzer and red cell distribution width indexhad highest diagnostic efficacy value up to 90.3%. Conclusion: We conclude that Mentzer and red cell distribution width index showed the highest diagnostic significance. The Mentzer index has the highest sensitivity whereas Ricerca index has the highest specificity. The red blood cell count, haemoglobin and mean cell volume.............

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