scholarly journals Early detection of subclinical nephritis in systemic lupus erythematosus patients

2021 ◽  
Vol 25 (3) ◽  
pp. 21-27
Author(s):  
Rana Saad-eldin ◽  
Esam Abo Al-Fadl ◽  
Nehal Fathy ◽  
Afaf El-Nashar
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Early Detection ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals Genetic and molecular biology of systemic lupus erythematosus among Iranian patients: an overview

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Meisam Gachpazan ◽  
Iman Akhlaghipour ◽  
Hamid Reza Rahimi ◽  
Ehsan Saburi ◽  
Majid Mojarrad ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Molecular Biology ◽  
Early Detection ◽  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Autoimmune Disorder ◽  
Main Body ◽  
Systemic Lupus ◽  
Cytokines And Chemokines ◽  
Iranian Patients

Abstract Background Systemic lupus erythematosus (SLE) is a clinicopathologically heterogeneous chronic autoimmune disorder affecting different organs and tissues. It has been reported that there is an increasing rate of SLE incidence among Iranian population. Moreover, the Iranian SLE patients have more severe clinical manifestations compared with other countries. Therefore, it is required to introduce novel methods for the early detection of SLE in this population. Various environmental and genetic factors are involved in SLE progression. Main body In present review we have summarized all of the reported genes which have been associated with clinicopathological features of SLE among Iranian patients. Conclusions Apart from the reported cytokines and chemokines, it was interestingly observed that the apoptosis related genes and non-coding RNAs were the most reported genetic abnormalities associated with SLE progression among Iranians. This review clarifies the genetics and molecular biology of SLE progression among Iranian cases. Moreover, this review paves the way of introducing an efficient panel of genetic markers for the early detection and better management of SLE in this population.

scholarly journals Systemic lupus erythematosus: challenges of early detection

2021 ◽  
Vol 18 (4) ◽  
pp. 162-166
Author(s):  
A. V. Pronevich ◽  
N. G. Kadochkina
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Early Detection ◽  
Lupus Erythematosus ◽  
Clinical Case ◽  
Rapid Development ◽  
Clinical Manifestations ◽  
Response To Therapy ◽  
Inadequate Response ◽  
Systemic Lupus ◽  
Treatment And Prevention

The article presents a clinical case of such difficult for detection disease assystemic lupus erythematosus (SLE), which is characterized by atypical debut options, rapid development of complications, inadequate response to therapy. It is emphasized that the first clinical manifestations of the disease are the most important for its timely diagnosis, beginning of treatment and prevention of complications. The study concludes that mistakes in the diagnosis, late beginning of treatment may be related to the absence of SLE awareness among physicians.

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