COLORIMETRIC AND ATOMIC ABSORPTION SPECTROMETRIC METHODS FOR THE DETERMINATION OF NEFAZODONE HYDROCHLORIDE AND TRAZODONE HYDROCHLORIDE IN PURE FORM AND PHARMACEUTICAL PREPARATIONS

2003 ◽  
Vol 12 (1) ◽  
pp. 9-13
Author(s):  
Gamal Ragab
Keyword(s):  
Atomic Absorption ◽  
Pharmaceutical Preparations ◽  
Pure Form ◽  
Atomic Absorption Spectrometric ◽  
Trazodone Hydrochloride

Potentiometric and Atomic Absorption Spectrometric Determination of Sulfonamides in Pharmaceutical Preparations

1981 ◽  
Vol 64 (5) ◽  
pp. 1158-1163
Author(s):  
Saad S M Hassan ◽  
Mohamed H Eldesouki
Keyword(s):  
Metal Ions ◽  
Atomic Absorption ◽  
Graphite Electrode ◽  
Copper Ions ◽  
Pharmaceutical Preparations ◽  
Ion Selective Electrodes ◽  
Copper Sulfides ◽  
Direct Titration ◽  
Atomic Absorption Spectrometric

Abstract Potentiometric and atomic absorption spectrometric (AAS) methods are described for the determination of various sulfonamides in tablets, suspensions, and injections, based on reactions with silver and copper ions. The methods involve direct titration at pH 8, using either a graphite electrode in which silver and copper sulfides have been precipitated, or ion selective electrodes to monitor the potential change. AAS measurements of the excess metal ions after metalsulfonamide reaction are also reported. Results compare favorably with those obtained using USP XIX procedures. The methods described are selective, simple, and precise.

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