Dose-dependent Elimination Kinetics of Theophylline

1979 ◽  
Vol 4 (6) ◽  
pp. 449-459 ◽  
Author(s):  
L. J. Lesko
Keyword(s):  
Elimination Kinetics ◽  
Kinetics Of ◽  
Dose Dependent

scholarly journals Dose-Dependent Change in Elimination Kinetics of Ethanol due to Shift of Dominant Metabolizing Enzyme from ADH 1 (Class I) to ADH 3 (Class III) in Mouse

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Takeshi Haseba ◽  
Kouji Kameyama ◽  
Keiko Mashimo ◽  
Youkichi Ohno
Keyword(s):  
The Other ◽  
Alcohol Metabolism ◽  
Class Iii ◽  
Elimination Kinetics ◽  
Ethanol Dose ◽  
Dependent Change ◽  
Metabolizing Enzyme ◽  
Kinetics Of ◽  
Dose Dependent ◽  
Adh Activity

ADH 1 and ADH 3 are major two ADH isozymes in the liver, which participate in systemic alcohol metabolism, mainly distributing in parenchymal and in sinusoidal endothelial cells of the liver, respectively. We investigated how these two ADHs contribute to the elimination kinetics of blood ethanol by administering ethanol to mice at various doses, and by measuring liver ADH activity and liver contents of both ADHs. The normalized AUC (AUC/dose) showed a concave increase with an increase in ethanol dose, inversely correlating with β.CLT(dose/AUC) linearly correlated with liver ADH activity and also with both the ADH-1 and -3 contents (mg/kg B.W.). When ADH-1 activity was calculated by multiplying ADH-1 content by itsVmax⁡/mg (4.0) and normalized by the ratio of liver ADH activity of each ethanol dose to that of the control, the theoretical ADH-1 activity decreased dose-dependently, correlating with β. On the other hand, the theoretical ADH-3 activity, which was calculated by subtracting ADH-1 activity from liver ADH activity and normalized, increased dose-dependently, correlating with the normalized AUC. These results suggested that the elimination kinetics of blood ethanol in mice was dose-dependently changed, accompanied by a shift of the dominant metabolizing enzyme from ADH 1 to ADH 3.

Theoretical study of the mechanisms for the homogenous gas-phase elimination kinetics of some 2-hydroxynitroalkanes

2006 ◽  
Vol 19 (12) ◽  
pp. 836-840 ◽  
Author(s):  
Rafael Añez ◽  
Rodolfo Izquierdo ◽  
Alba Vidal ◽  
Tania Cordova ◽  
Aníbal Sierraalta ◽  
...  
Keyword(s):  
Gas Phase ◽  
Theoretical Study ◽  
Elimination Kinetics ◽  
Kinetics Of ◽  
Phase Elimination

scholarly journals Regional distribution and elimination kinetics of imipramine in rat brain after multiple dosages.

1986 ◽  
Vol 34 (2) ◽  
pp. 927-930 ◽  
Author(s):  
Mikio Masada ◽  
Kazutoshi Suzuki ◽  
Sadao Kikuta ◽  
Shinji Yamashita ◽  
Kunio Nakanishi ◽  
...  
Keyword(s):  
Rat Brain ◽  
Regional Distribution ◽  
Elimination Kinetics ◽  
Kinetics Of

Theophylline Toxicity in a Premature Neonate – Elimination Kinetics of Exchange Transfusion

1993 ◽  
Vol 31 (4) ◽  
pp. 639-644 ◽  
Author(s):  
Harold H. Osborn ◽  
Glendon Henry ◽  
Paul Wax ◽  
Robert Hoffman ◽  
Mary Ann Howland
Keyword(s):  
Exchange Transfusion ◽  
Premature Neonate ◽  
Elimination Kinetics ◽  
Kinetics Of

The Influence of Surgery on the Elimination Kinetics of Disopyramide in Pigs

2009 ◽  
Vol 59 (1) ◽  
pp. 86-88
Author(s):  
L. E. Pedersen ◽  
K. Hermansen ◽  
H. O. Olesen ◽  
S. N. Rasmussen
Keyword(s):  
Elimination Kinetics ◽  
Kinetics Of
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