Antianginal Efficacy of the Combination of Trimetazidine-Propranolol Compared with Isosorbide Dinitrate-Propranolol in Patients with Stable Angina

1997 ◽  
Vol 13 (1) ◽  
pp. 8-14 ◽  
Author(s):  
Andreas P. Michaelides ◽  
Konstantinos Spiropoulos ◽  
Konstantinos Dimopoulos ◽  
Demetrios Athanasiades ◽  
Pavlos Toutouzas
1992 ◽  
Vol 19 (Supplement 1) ◽  
pp. S114-S116 ◽  
Author(s):  
W. Nahrendorf ◽  
A. Rading ◽  
G. Steinig ◽  
R. van der Does ◽  
A. Schlote

1994 ◽  
Vol 56 (2) ◽  
pp. 229-234 ◽  
Author(s):  
Bruce A Sussex ◽  
Norman R C Campbell ◽  
Mahesh K Raju ◽  
Donald W Mckay

1986 ◽  
Vol 14 (6) ◽  
pp. 303-305
Author(s):  
Matti Äärynen ◽  
Kari Soininen

Ten patients with stable exercise-induced angina took part in this study. Isosorbide dinitrate and placebo sprays were administered in a double-blind, randomized crossover study. The dose of isosorbide dinitrate given was two squirts (=2–5 mg) 2 min before testing. When taken before exercise it significantly improved (p≤0.014) exercise tolerance. Significant (p≤0.0005) ischaemic changes in the electrocardiogram also occurred. These effects occurred later than with placebo. Exercise time was prolonged with the active drug. The results of this study show that isosorbide dinitrate spray improves the exercise tolerance of patients with ischaemic heart disease.


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