A Comparison of Carvedilol with a Combination of Propranolol and Isosorbide Dinitrate in the Chronic Treatment of Stable Angina

1992 ◽  
Vol 19 (Supplement 1) ◽  
pp. S114-S116 ◽  
Author(s):  
W. Nahrendorf ◽  
A. Rading ◽  
G. Steinig ◽  
R. van der Does ◽  
A. Schlote
Keyword(s):  
Isosorbide Dinitrate ◽  
Stable Angina ◽  
Chronic Treatment

Antianginal Effect of Isosorbide Dinitrate Spray in Patients with Exercise-Induced Stable Angina

1986 ◽  
Vol 14 (6) ◽  
pp. 303-305
Author(s):  
Matti Äärynen ◽  
Kari Soininen
Keyword(s):  
Heart Disease ◽  
Isosorbide Dinitrate ◽  
Stable Angina ◽  
Exercise Tolerance ◽  
Active Drug ◽  
Double Blind ◽  
Exercise Time ◽  
Antianginal Effect ◽  
Exercise Induced ◽  
Randomized Crossover Study

Ten patients with stable exercise-induced angina took part in this study. Isosorbide dinitrate and placebo sprays were administered in a double-blind, randomized crossover study. The dose of isosorbide dinitrate given was two squirts (=2–5 mg) 2 min before testing. When taken before exercise it significantly improved (p≤0.014) exercise tolerance. Significant (p≤0.0005) ischaemic changes in the electrocardiogram also occurred. These effects occurred later than with placebo. Exercise time was prolonged with the active drug. The results of this study show that isosorbide dinitrate spray improves the exercise tolerance of patients with ischaemic heart disease.

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