Antianginal Effect of Isosorbide Dinitrate Spray in Patients with Exercise-Induced Stable Angina

1986 ◽  
Vol 14 (6) ◽  
pp. 303-305
Author(s):  
Matti Äärynen ◽  
Kari Soininen
Keyword(s):  
Heart Disease ◽  
Isosorbide Dinitrate ◽  
Stable Angina ◽  
Exercise Tolerance ◽  
Active Drug ◽  
Double Blind ◽  
Exercise Time ◽  
Antianginal Effect ◽  
Exercise Induced ◽  
Randomized Crossover Study

Ten patients with stable exercise-induced angina took part in this study. Isosorbide dinitrate and placebo sprays were administered in a double-blind, randomized crossover study. The dose of isosorbide dinitrate given was two squirts (=2–5 mg) 2 min before testing. When taken before exercise it significantly improved (p≤0.014) exercise tolerance. Significant (p≤0.0005) ischaemic changes in the electrocardiogram also occurred. These effects occurred later than with placebo. Exercise time was prolonged with the active drug. The results of this study show that isosorbide dinitrate spray improves the exercise tolerance of patients with ischaemic heart disease.

scholarly journals A Dose-Dependent Improvement in Exercise Tolerance in Patients With Stable Angina Treated With Mildronate: A Clinical Trial “MILSS I”

Medicina ◽  
2011 ◽  
Vol 47 (10) ◽  
pp. 78 ◽  
Author(s):  
Vilnis Dzerve ◽  
Keyword(s):  
Stable Angina ◽  
Standard Therapy ◽  
Exercise Tolerance ◽  
Limiting Factor ◽  
Bicycle Ergometry ◽  
Double Blind ◽  
Exercise Time ◽  
Total Exercise Time ◽  
The Mean ◽  
The Difference

Objective. To assess the efficacy of various doses of Mildronate in combination with standard therapy for the exercise tolerance of patients with stable angina pectoris. The primary efficacy variable was the change in exercise time in bicycle ergometry from the baseline to 12 weeks of treatment. The secondary endpoints were the changes in maximum achieved load and time to the onset of angina from the baseline to week 12. Material and Methods. A total of 512 patients with chronic coronary heart disease who had ischemia as the limiting factor in the exercise test from 72 study centers in 4 countries were enrolled in this prospective, randomized, double-blind, placebo controlled phase 2 study. The patients were assigned to either 4 groups receiving standard therapy plus Mildronate at different daily doses or 1 group receiving standard therapy plus placebo. Results. The mean change in the total exercise time in the mildronate 100 mg and mildronate 300 mg groups was –2.12±108.45 and 11.48±62.03 seconds, respectively. The mean change for the placebo group was –7.10±81.78 seconds. The difference between Mildronate 100 mg and 300 mg and placebo groups was not significant. Patients in the Mildronate 1000 mg group showed a remarkable increase in the mean change in the total exercise time (35.18±53.29 seconds, P=0.002). Mildronate at a dose of 3000 mg caused a smaller increase as compared with a dose of 1000 mg. Similar changes in the secondary end parameters were observed. Conclusion. The most effective dose of Mildronate in combination with standard therapy was found to be 500 mg twice a day.

Effects of Bepridil on exercise tolerance in chronic stable angina: A double-blind, randomized, placebo-controlled, crossover trial

1984 ◽  
Vol 53 (6) ◽  
pp. 679-683 ◽  
Author(s):  
James A. Hill ◽  
John T. O'Brien ◽  
Elizabeth Scott ◽  
C.Richard Conti ◽  
Carl J. Pepine
Keyword(s):  
Stable Angina ◽  
Exercise Tolerance ◽  
Crossover Trial ◽  
Chronic Stable Angina ◽  
Double Blind

Chronic Stable Angina: Comparison of Verapamil and Propranolol

1982 ◽  
Vol 10 (5) ◽  
pp. 361-366 ◽  
Author(s):  
E Southall ◽  
N R Nutt ◽  
R D Thomas
Keyword(s):  
Angina Pectoris ◽  
Exercise Testing ◽  
Stable Angina ◽  
Crossover Trial ◽  
Chronic Stable Angina ◽  
Stable Angina Pectoris ◽  
Double Blind ◽  
Exercise Time ◽  
Electrocardiographic Monitoring ◽  
St Segment

The effect of verapamil 120 mg t.d.s. was compared with propranolol 160 mg b.d. in the treatment of stable angina pectoris. Nineteen patients were studied in a randomized, double-blind, crossover trial, using patient diaries, exercise-testing and ambulatory electrocardiographic monitoring. Both drugs were given for 1 month. On average the number of attacks of angina was reduced equally by verapamil and propranolol. The degree of electrocardiographic evidence of myocardial ischaemia was decreased by the same amount, but verapamil was significantly more effective in prolonging the exercise time. Both drugs reduced the number of episodes of ST-segment depression during 24 hours of ambulatory electrocardiographic monitoring, which was analyzed in nine patients. It is concluded that verapamil compares very favourably with propranolol in the treatment of stable angina, and is more beneficial in improving exercise capacity.

scholarly journals A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effectiveness of a Food Supplement Containing Creatine and D-Ribose Combined with a Physical Exercise Program in Increasing Stress Tolerance in Patients with Ischemic Heart Disease

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 3075
Author(s):  
Giuseppe Derosa ◽  
Silvia Pasqualotto ◽  
Gabriele Catena ◽  
Angela D’Angelo ◽  
Antonio Maggi ◽  
...  
Keyword(s):  
Heart Disease ◽  
Physical Exercise ◽  
Ischemic Heart Disease ◽  
Active Treatment ◽  
Exercise Tolerance ◽  
Vitamin B6 ◽  
Vitamin B1 ◽  
Exercise Program ◽  
Double Product ◽  
Double Blind

The aim of this study is to establish whether a supplement of creatine and ribose combined with a physical exercise program can improve the total work capacity during exercise in a population of patients with known ischemic heart disease. A double-blind, six-month study was designed in which 53 patients were enrolled and randomized to take either a nutraceutical composition containing creatine, D-ribose, vitamin B1, and vitamin B6 (active treatment) or the placebo. Both the nutraceutical supplement and the placebo were supplied by Giellepi S.p.A. Health Science in Lissone, Italy. After six months of study, the cardiac double product at the peak of the load, the delta double product, and the chronotropic index were higher in the active treatment group than in the placebo group. We can conclude that a supplementation with creatine, D-ribose, vitamin B1, and vitamin B6, in addition to standard therapy and a physical exercise program, seems to be helpful in improving exercise tolerance compared to the placebo in a population with cardiovascular disease. However, this needs to be further studied, given that there is no clear evidence that the double product can be used as a surrogate measure of exercise tolerance.

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