Erythromycin-resistant group A streptococci in the US

2002 ◽  
Vol &NA; (1335) ◽  
pp. 13
Author(s):  
&NA;
2006 ◽  
Vol 25 (10) ◽  
pp. 880-883 ◽  
Author(s):  
Cinzia Spinaci ◽  
Gloria Magi ◽  
Pietro E. Varaldo ◽  
Bruna Facinelli

2000 ◽  
Vol 38 (7) ◽  
pp. 2475-2479 ◽  
Author(s):  
Jing-Jou Yan ◽  
Hsiu-Mei Wu ◽  
Ah-Huei Huang ◽  
Hsiu-Mei Fu ◽  
Chen-Ting Lee ◽  
...  

A total of 204 nonrepetitive isolates of group A streptococci (GAS), including 107 randomly collected between 1992 and 1995 and 66 and 31 consecutively collected in 1997 and 1998, respectively, from a university hospital in southern Taiwan were examined to determine the prevalence and mechanisms of erythromycin resistance among these isolates. Resistance to erythromycin was detected in 129 isolates (63.2%) by the agar dilution test. Of these, 42 isolates (32.6%) were assigned to the constitutive macrolide, lincosamide, and streptogramin B resistance (cMLS) phenotype, and all carried the ermBgene; 4 (3.1%) were assigned to the inducible MLS resistance (iMLS) phenotype, and all harbored the ermTR gene; and 83 (64.3%) were erythromycin resistant but susceptible to clindamycin (M phenotype), and all possessed the mefA gene. Distributed by years, the rates of erythromycin resistance and different phenotypes were 61.7% (53.0% cMLS, 6.1% iMLS, and 40.9% M phenotype) between 1992 and 1995, 62.1% (12.2% cMLS and 87.8% M phenotype) in 1997, and 71.0% (9.1% cMLS and 90.9% M phenotype) in 1998. Pulsed-field gel electrophoresis showed that all but 2 cMLS isolates were clonal in origin, and 17 clones were detected among the M-phenotype isolates. These results indicate that the high incidence and increasing rate of erythromycin-resistant GAS in southern Taiwan are due to the prevalence of multiple M-phenotype clones and that clindamycin may be the drug of choice for the treatment of infections with GAS in penicillin-hypersensitive patients in this area.


2006 ◽  
Vol 1289 ◽  
pp. 95-98
Author(s):  
Robert R. Tanz ◽  
Stanford T. Shulman ◽  
Virginia D. Shortridge ◽  
Bernard Beall ◽  
Emily Cederlund ◽  
...  

BMJ ◽  
1974 ◽  
Vol 3 (5928) ◽  
pp. 467-467 ◽  
Author(s):  
J A Emslie

2002 ◽  
Vol 346 (16) ◽  
pp. 1200-1206 ◽  
Author(s):  
Judith M. Martin ◽  
Michael Green ◽  
Karen A. Barbadora ◽  
Ellen R. Wald

Sign in / Sign up

Export Citation Format

Share Document