Thyroid Follicular Adenoma Producing Parathyroid Hormone-related Protein with a Normal Serum Calcium Level

For this study, calcium level in the blood was studied in 20 normal individuals between the ages of 20 and 25 years to find out the normal serum-calcium level in them in order that this finding might serve as a control. It was found to vary from 8·9 to 11·0 mg. per cent. (see Table I).

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Direct Comparison of Sustained Infusion of Human Parathyroid Hormone-Related Protein-(1–36) [hPTHrP-(1–36)]VersushPTH-(1–34) on Serum Calcium, Plasma 1,25-Dihydroxyvitamin D Concentrations, and Fractional Calcium Excretion in Healthy Human Volunteers

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2002-020773 ◽

2003 ◽

Vol 88 (4) ◽

pp. 1603-1609 ◽

Cited By ~ 90

Author(s):

Mara J. Horwitz ◽

Mary Beth Tedesco ◽

Susan M. Sereika ◽

Bruce W. Hollis ◽

Adolfo Garcia-Ocaña ◽

...

Keyword(s):

Parathyroid Hormone ◽

Serum Calcium ◽

Calcium Excretion ◽

Related Protein ◽

Human Parathyroid Hormone ◽

Healthy Human ◽

Dihydroxyvitamin D ◽

1,25 Dihydroxyvitamin D ◽

Parathyroid Hormone Related Protein ◽

Human Volunteers

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Successful Treatment for Hypercalcemia due to Cosecretion of Parathyroid Hormone-Related Protein and 1,25-Dihydroxyvitamin D3 in Non-Small-Cell Lung Cancer: A Case Report and Literature Review

Case Reports in Pulmonology ◽

10.1155/2020/2475725 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Takunori Ogawa ◽

Jun Miyata ◽

Koichi Fukunaga ◽

Akihiko Kawana ◽

Takashi Inoue

Keyword(s):

Lung Cancer ◽

Case Report ◽

Parathyroid Hormone ◽

Serum Calcium ◽

Successful Treatment ◽

Related Protein ◽

Hypercalcemia Of Malignancy ◽

Dihydroxyvitamin D ◽

1,25 Dihydroxyvitamin D ◽

Parathyroid Hormone Related Protein

Hypercalcemia of malignancy frequently manifests as paraneoplastic syndrome in patients with solid tumors. A 71-year-old man was diagnosed with stage IIIB lung squamous cell carcinoma. Laboratory examination revealed high serum calcium concentration with elevated serum parathyroid hormone-related protein (PTHrP) and 1,25-dihydroxyvitamin D3 levels. As the patient did not respond to the initial treatment with calcitonin, extracellular fluid infusion, and chemotherapy, systemic prednisolone was administered additionally. Thus, the levels of serum calcium normalized and PTHrP and 1,25-dihydroxyvitamin D3 decreased simultaneously. To our knowledge, this is the first case report on the successful treatment of hypercalcemia of malignancy caused by PTHrP and 1,25-dihydroxyvitamin D3 cosecretion in a patient with lung cancer.

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Unusual behaviour of an unusual tumour: calcitriol-induced hypercalcaemia in metastatic oesophageal neuroendocrine carcinoma

BMJ Case Reports ◽

10.1136/bcr-2020-235209 ◽

2020 ◽

Vol 13 (8) ◽

pp. e235209

Author(s):

Filip Ionescu ◽

Ioana Petrescu ◽

Maria Marin

Keyword(s):

Parathyroid Hormone ◽

Serum Calcium ◽

Neuroendocrine Carcinoma ◽

Solid Tumours ◽

Related Protein ◽

Dihydroxyvitamin D ◽

1,25 Dihydroxyvitamin D ◽

Parathyroid Hormone Related Protein ◽

Solid Malignancies ◽

Osteolytic Metastases

Hypercalcaemia in malignancy is most commonly caused by paraneoplastic secretion of parathyroid hormone-related protein or osteolytic metastases. Very rarely (<1% of cases), the mechanism behind increased serum calcium is increased production of calcitriol (1,25-dihydroxyvitamin D) and even rarer is the occurrence of this phenomenon in solid malignancies, with few such instances reported in the literature. We present a case of a neuroendocrine malignancy originating in the oesophagus associated with calcitriol-induced hypercalcaemia, a phenomenon that has not been previously described. We review the pathophysiology of calcitriol-induced hypercalcaemia and previously reported cases of solid tumours with this presentation.

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