scholarly journals Final Report Summary: Radiation dosimetry of Cu-64-labeled radiotherapy agents using PET [Positron Emission Tomography]

2002 ◽  
Author(s):  
Carolyn J Anderson ◽  
P D Cutler
Keyword(s):  
Positron Emission Tomography ◽  
Radiation Dosimetry ◽  
Emission Tomography ◽  
Final Report ◽  
Positron Emission

Preclinical assessment of [68Ga]Ga-Cell Death Indicator (CDI): a novel hsp90 ligand for positron emission tomography of cell death

2021 ◽  
Vol 14 ◽  
Author(s):  
Ivan Ho Shon ◽  
Divesh Kumar ◽  
Mark Schreuder ◽  
Jennifer Guille ◽  
John Doan ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Cell Death ◽  
High Performance ◽  
Radiation Dosimetry ◽  
Bladder Wall ◽  
Emission Tomography ◽  
Positron Emission ◽  
Post Synthesis ◽  
Shock Proteins ◽  
Dying Cells

Background: 4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid (GSAO) when conjugated with a bifunctional chelator 2,2'-(7-(1-carboxy-4-((2,5-dioxopyrrolidin-1-yl)oxy)-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid (NODAGA) (hereafter referred to as Cell Death Indicator [CDI]), enters dead and dying cells and binds to 90kDa heat shock proteins (hsp90). Objective: This study assesses stability, biodistribution, imaging, and radiation dosimetry of [68Ga]Ga-CDI for positron emission tomography (PET). Methods: Preparation of [68Ga]Ga-CDI was performed as previously described. Product stability and stability in plasma were assessed using high-performance liquid chromatography. Biodistribution and imaging were conducted in ten healthy male Lewis rats at 1 and 2 h following intravenous [68Ga]Ga-CDI injection. Human radiation dosimetry was estimated by extrapolation for a standard reference man and calculated with OLINDA/EXM 1.1. Results: Radiochemical purity of [68Ga]Ga-CDI averaged 93.8% in the product and 86.7% in plasma at 4 h post-synthesis. The highest concentration of [68Ga]Ga-CDI is observed in the kidneys; [68Ga]Ga-CDI is excreted in the urine, and mean retained activity was 32.4% and 21.4% at 1 and 2 h post-injection. Lower concentrations of [68Ga]Ga-CDI were present in the small bowel and liver. PET CT was concordant and additionally demonstrated focal growth plate uptake. The effective dose for [68Ga]Ga-CDI is 2.16E-02 mSv/MBq, and the urinary bladder wall received the highest dose (1.65E-02mSv/Mbq). Conclusions: [68Ga]Ga-CDI is stable and has favourable biodistribution, imaging, and radiation dosimetry for imaging of dead and dying cells. Human studies are underway.

scholarly journals Development of a New Positron Emission Tomography Tracer for Targeting Tumor Angiogenesis: Synthesis, Small Animal Imaging, and Radiation Dosimetry

Molecules ◽  
2013 ◽  
Vol 18 (5) ◽  
pp. 5594-5610 ◽  
Author(s):  
Cam Patterson ◽  
C. Frederick ◽  
Hong Yuan ◽  
Laura Dyer ◽  
Pamela Lockyer ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Tumor Angiogenesis ◽  
Radiation Dosimetry ◽  
Small Animal Imaging ◽  
Small Animal ◽  
Emission Tomography ◽  
Positron Emission Tomography Tracer ◽  
Positron Emission ◽  
Animal Imaging

Whole-Body Distribution and Radiation Dosimetry of68Ga-NOTA-RGD, a Positron Emission Tomography Agent for Angiogenesis Imaging

2012 ◽  
Vol 27 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Joong Hyun Kim ◽  
Jae Sung Lee ◽  
Keon Wook Kang ◽  
Ho-Young Lee ◽  
Sae-Won Han ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Radiation Dosimetry ◽  
Emission Tomography ◽  
Whole Body ◽  
Body Distribution ◽  
Positron Emission

Radiation dosimetry of [18F]GP1 for imaging activated glycoprotein IIb/IIIa receptors with positron emission tomography in patients with acute thromboembolism

2019 ◽  
Vol 72-73 ◽  
pp. 45-48 ◽  
Author(s):  
Narae Lee ◽  
Inhye Oh ◽  
Sun Young Chae ◽  
Soyoung Jin ◽  
Seung Jun Oh ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Radiation Dosimetry ◽  
Emission Tomography ◽  
Positron Emission

Biodistribution and radiation dosimetry in humans of [11C]FLB 457, a positron emission tomography ligand for the extrastriatal dopamine D2 receptor

2014 ◽  
Vol 41 (1) ◽  
pp. 102-105 ◽  
Author(s):  
Yasuyuki Kimura ◽  
Hiroshi Ito ◽  
Takahiro Shiraishi ◽  
Hironobu Fujiwara ◽  
Fumitoshi Kodaka ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Radiation Dosimetry ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Emission Tomography ◽  
Dopamine D2 ◽  
Positron Emission ◽  
Positron Emission Tomography Ligand
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