Background:
Colony Stimulating Factor-1 Receptor (CSF-1R) is associated with
malignancy, invasiveness and poor prognosis of tumors, and pyrimidine derivatives are considered as
a novel class of CSF-1R inhibitor.
Methods:
To explore the relationship between the structures of substituted pyrimidine derivatives
and their inhibitory activities against CSF-1R, CoMFA and CoMSIA analyses, and molecular
docking studies were performed on a dataset of forty-four compounds.
Results:
We found in CoMFA model including steric and electrostatic fields for the training set, the
cross-validated q2 value was 0.617 and the non-cross-validated r2 value was 0.983. While, the crossvalidated
q2 value was 0.637 and the non-cross-validated r2 value was 0.984 in CoMSIA Model
which include steric, electrostatic and hydrophobic fields. 3D equipotential maps generated from
CoMFA and CoMSIA along with the docking binding structures provided enough information about
the structural requirements for better activity.
Conclusion:
The data generated from the present study helped us to predict the activity of new
inhibitors and further design some novel and potent CSF-1R inhibitors.
3D-QSAR and docking studies of arylmethylamine-based DPP IV inhibitors