Insights into Structure-Activity Relationships and CNS Therapeutic Applications of NR2B Selective Antagonists

Structure Activity ◽

Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders

Pharmacology & Therapeutics ◽

10.1016/j.pharmthera.2010.08.013 ◽

2011 ◽

Vol 129 (2) ◽

pp. 120-148 ◽

Cited By ~ 119

Author(s):

Marcello Leopoldo ◽

Enza Lacivita ◽

Francesco Berardi ◽

Roberto Perrone ◽

Peter B. Hedlund

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Central Nervous System Disorders ◽

Structure−Activity Relationships of 1-Alkyl-5-(3,4-dichlorophenyl)- 5-{2-[(3-substituted)-1-azetidinyl]ethyl}-2-piperidones. 1. Selective Antagonists of the Neurokinin-2 Receptor

Journal of Medicinal Chemistry ◽

10.1021/jm0209331 ◽

2002 ◽

Vol 45 (24) ◽

pp. 5365-5377 ◽

Cited By ~ 33

Author(s):

A. Roderick MacKenzie ◽

Allan P. Marchington ◽

Donald S. Middleton ◽

Sandra D. Newman ◽

Barry C. Jones

Keyword(s):

Structure Activity ◽

Selective Antagonists ◽

Substituted 1

Choline-Containing Phospholipids: Structure-Activity Relationships Versus Therapeutic Applications

Current Medicinal Chemistry ◽

10.2174/0929867322666151029104152 ◽

2015 ◽

Vol 22 (38) ◽

pp. 4328-4340 ◽

Cited By ~ 7

Author(s):

S.K. Tayebati ◽

G. Marucci ◽

C. Santinelli ◽

M. Buccioni ◽

F. Amenta

Keyword(s):

Structure—Activity Relationships of a Novel Class of Endothelin Receptor Selective Antagonists; 6-Carboxy-2-isopropylamino-5,7-diarylcyclopenteno[1,2-b]pyridines.

ChemInform ◽

10.1002/chin.200430233 ◽

2004 ◽

Vol 35 (30) ◽

Author(s):

Norikazu Ohtake ◽

et al. et al.

Keyword(s):

Endothelin Receptor ◽

Structure Activity ◽

.alpha.- and .beta.-Adrenoceptors: From the Gene to the Clinic. 2. Structure-Activity Relationships and Therapeutic Applications

Journal of Medicinal Chemistry ◽

10.1021/jm00019a001 ◽

1995 ◽

Vol 38 (19) ◽

pp. 3681-3716 ◽

Cited By ~ 130

Author(s):

Robert R. Ruffolo ◽

William Bondinell ◽

J. Paul Hieble

Keyword(s):

Beta Adrenoceptors ◽

Synthesis and structure–activity relationships of potent and orally active sulfonamide ETB selective antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(00)00305-9 ◽

2001 ◽

Vol 9 (4) ◽

pp. 897-907 ◽

Cited By ~ 21

Author(s):

Yasuhiko Kanda ◽

Yasuyuki Kawanishi ◽

Katsuo Oda ◽

Teruo Sakata ◽

Shin-ichi Mihara ◽

...

Keyword(s):

Structure Activity ◽

Selective Antagonists ◽

Orally Active

ChemInform Abstract: α- and β-Adrenoceptors: From the Gene to the Clinic. Part 2. Structure-Activity Relationships and Therapeutic Applications

ChemInform ◽

10.1002/chin.199603312 ◽

2010 ◽

Vol 27 (3) ◽

pp. no-no

Author(s):

R. R. JUN. RUFFOLO ◽

W. BONDINELL ◽

J. P. HIEBLE

Keyword(s):

Structure–Activity Relationships and Pharmacophore Model of a Noncompetitive Pyrazoline Containing Class of GluN2C/GluN2D Selective Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm400652r ◽

2013 ◽

Vol 56 (16) ◽

pp. 6434-6456 ◽

Cited By ~ 31

Author(s):

Timothy M. Acker ◽

Alpa Khatri ◽

Katie M. Vance ◽

Cathryn Slabber ◽

John Bacsa ◽

...

Keyword(s):

Pharmacophore Model ◽

Structure Activity ◽

CB1 Cannabinoid Antagonists: Structure-Activity Relationships and Potential Therapeutic Applications

Current Topics in Medicinal Chemistry ◽

10.2174/156802608783498050 ◽

2008 ◽

Vol 8 (3) ◽

pp. 205-230 ◽

Cited By ~ 40

Author(s):

Nadine Jagerovic ◽

Cristina Fernandez-Fernandez ◽

Pilar Goya

Keyword(s):

Structure Activity ◽

Cannabinoid Antagonists

Structure–activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP4 receptor

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2008.01.103 ◽

2008 ◽

Vol 18 (6) ◽

pp. 2048-2054 ◽

Cited By ~ 11

Author(s):

Jason D. Burch ◽

Michel Belley ◽

Réjean Fortin ◽

Denis Deschênes ◽

Mario Girard ◽

...

Keyword(s):

Pharmacokinetic Parameters ◽

Ep4 Receptor ◽

Structure Activity ◽