Choline-Containing Phospholipids: Structure-Activity Relationships Versus Therapeutic Applications

2015 ◽  
Vol 22 (38) ◽  
pp. 4328-4340 ◽  
Author(s):  
S.K. Tayebati ◽  
G. Marucci ◽  
C. Santinelli ◽  
M. Buccioni ◽  
F. Amenta
Keyword(s):  
Therapeutic Applications ◽  
Structure Activity Relationships ◽  
Structure Activity

Insights into Structure-Activity Relationships and CNS Therapeutic Applications of NR2B Selective Antagonists

2010 ◽  
Vol 17 (34) ◽  
pp. 4166-4190 ◽  
Author(s):  
C. Beinat ◽  
S. Banister ◽  
I. Moussa ◽  
A. J. Reynolds ◽  
C. S.P. McErlean ◽  
...  
Keyword(s):  
Therapeutic Applications ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Selective Antagonists

scholarly journals Aza- and Azo-Stilbenes: Bio-Isosteric Analogs of Resveratrol

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 605 ◽  
Author(s):  
Gérard Lizard ◽  
Norbert Latruffe ◽  
Dominique Vervandier-Fasseur
Keyword(s):  
Therapeutic Potential ◽  
Biological Activities ◽  
Research Groups ◽  
Aromatic Rings ◽  
Therapeutic Applications ◽  
Structure Activity Relationships ◽  
Natural Polyphenols ◽  
Structure Activity ◽  
Resveratrol Analogs ◽  
Resveratrol Derivatives

Several series of natural polyphenols are described for their biological and therapeutic potential. Natural stilbenoid polyphenols, such as trans-resveratrol, pterostilbene and piceatannol are well-known for their numerous biological activities. However, their moderate bio-availabilities, especially for trans-resveratrol, prompted numerous research groups to investigate innovative and relevant synthetic resveratrol derivatives. This review is focused on isosteric resveratrol analogs aza-stilbenes and azo-stilbenes in which the C=C bond between both aromatic rings was replaced with C=N or N=N bonds, respectively. In each series, synthetic ways will be displayed, and structural sights will be highlighted and compared with those of resveratrol. The biological activities of some of these molecules will be presented as well as their potential therapeutic applications. In some cases, structure-activity relationships will be discussed.

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