Inhibitors of Selected Bacterial Metalloenzymes

The utilization of bacterial metalloenzymes, especially ones not having mammalian (human) counterparts, has drawn attention to develop novel antibacterial agents to overcome drug resistance and especially multidrug resistance. In this review, we focus on the recent achievements on the development of inhibitors of bacterial enzymes peptide deformylase (PDF), metallo-β-lactamase (MBL), methionine aminopeptidase (MetAP) and UDP-3-O-acyl- N-acetylglucosamine deacetylase (LpxC). The state of the art of the design and investigation of inhibitors of bacterial metalloenzymes is presented, and challenges are outlined and discussed.

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Clinical relevance of in vitro drug resistance testing in childhood acute lymphoblastic leukemia: The state of the art

Medical and Pediatric Oncology ◽

10.1002/mpo.2950220502 ◽

1994 ◽

Vol 22 (5) ◽

pp. 299-308 ◽

Cited By ~ 23

Author(s):

Rob Pieters ◽

Gertjan J. L. Kaspers ◽

Edwin Klumper ◽

Anjo J.P. Veerman

Keyword(s):

Drug Resistance ◽

Acute Lymphoblastic Leukemia ◽

Clinical Relevance ◽

State Of The Art ◽

Lymphoblastic Leukemia ◽

The State ◽

Childhood Acute Lymphoblastic Leukemia ◽

Resistance Testing ◽

Drug Resistance Testing

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Practical Picture Processing

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100051700 ◽

1974 ◽

Vol 32 ◽

pp. 338-339

Author(s):

T. A. Welton

Keyword(s):

Radiation Damage ◽

Coherence Length ◽

Spatial Information ◽

State Of The Art ◽

Coherent Radiation ◽

The State ◽

Energy Spread ◽

Electron Micrograph ◽

Picture Processing ◽

Molecular Skeleton

Various authors have emphasized the spatial information resident in an electron micrograph taken with adequately coherent radiation. In view of the completion of at least one such instrument, this opportunity is taken to summarize the state of the art of processing such micrographs. We use the usual symbols for the aberration coefficients, and supplement these with £ and 6 for the transverse coherence length and the fractional energy spread respectively. He also assume a weak, biologically interesting sample, with principal interest lying in the molecular skeleton remaining after obvious hydrogen loss and other radiation damage has occurred.

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