Multifunctional Enzymes as Targets for the Treatment of Tuberculosis: Paving the Way for New Anti-TB Drugs

In spite of the medical and technological developments of the last centuries, Tuberculosis (TB) has remained a challenging disease, with a limited number of therapeutic options, particularly in light of the increase in drug-resistant cases. The search for new molecules continues, with several candidates currently in clinical testing and ongoing efforts to identify novel targets. This work summarizes recent developments on anti-TB therapy, starting by discussing the current epidemiologic status and presenting an overview of the history of anti-tuberculosis drug discovery. Special attention is dedicated to five multifunctional enzymes that are regarded as promising targets for new anti-TB drugs: 5-aminoimidazole4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase (ATIC); 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBPS)/GTP cyclohydrolase II (GCHII); glutamine dependent NAD+ Synthetase (NadE); chorismate synthase (CS); and Tryptophan synthase (TS). These enzymes are involved in metabolic pathways critical for the M. tuberculosis survival, growth or replication, but that are not expressed in humans or have significant differences in terms of functionality, which makes them appealing targets. Their function, structure, possible catalytic mechanisms and current inhibition strategies and inhibitors are reviewed and discussed.

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A Critical Examination of the History of Communication in Kingston: Technology’s role in Social Justice in the Kingston Community

Inquiry@Queen's Undergraduate Research Conference Proceedings ◽

10.24908/iqurcp.7803 ◽

2017 ◽

Author(s):

Nate Preston

Keyword(s):

Social Justice ◽

Critical Examination ◽

Communications Technology ◽

Engineering Community ◽

Mainstream Media ◽

Recent Developments ◽

Technological Developments ◽

History Of ◽

Just Society ◽

Personal Accounts

Information & Communications technology is developing at an astounding rate. Recent developments in Information & Communications technology have given consumers the power to communicate with others from almost anywhere, and with greater reliability. Mainstream media and the engineering community often applaud these technologies for helping to create a more transparent, pluralistic, global, and just society. However, many of these new technological developments are inaccessible and alienating to many members of the community. This paper examines the role that Information & Communications technology has played in the Kingston community. Published historical and personal accounts made by members of the Kingston community are compared and contrasted with those from the Queen’s University Control and Communications Degree program.

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Migration and Modernities

10.3366/edinburgh/9781474440349.001.0001 ◽

2019 ◽

Keyword(s):

Native Americans ◽

Literary History ◽

Historical Study ◽

Racial Categories ◽

Geographic Boundaries ◽

The Us ◽

Technological Developments ◽

History Of ◽

The Aesthetic ◽

Eighteenth And Nineteenth Centuries

Migration and Modernities recovers a comparative literary history of migration by bringing together scholars from the US and Europe to explore the connections between migrant experiences and the uneven emergence of modernity. The collection initiates transnational, transcultural and interdisciplinary conversations about migration in the eighteenth and nineteenth centuries, demonstrating how mobility unsettles the geographic boundaries, temporal periodization, and racial categories we often use to organize literary and historical study. Migrants are by definition liminal, and many have existed historically in the spaces between nations, regions or ethnicities. In exploring these spaces, Migration and Modernities also investigates the origins of current debates about belonging, rights, and citizenship. Its chapters traverse the globe, revealing the experiences — real or imagined — of eighteenth- and nineteenth-century migrants, from dispossessed Native Americans to soldiers in South America, Turkish refugees to Scottish settlers. They explore the aesthetic and rhetorical frameworks used to represent migrant experiences during a time when imperial expansion and technological developments made the fortunes of some migrants and made exiles out of others. These frameworks continue to influence the narratives we tell ourselves about migration today and were crucial in producing a distinctively modern subjectivity in which mobility and rootlessness have become normative.

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