Global perceptions of the current and future impacts of COVID-19 on hereditary angioedema management

Background: The coronavirus disease 2019 (COVID-19) pandemic has greatly affected health-care provision across the globe. Management of chronic ailments has become challenging because of the strained health-care resources and social distancing measures that prevent on-site clinical visits and treatments. Hereditary angioedema (HAE) is a debilitating, chronic disease characterized by unpredictable swelling attacks in various parts of the body. Controlling HAE symptoms often requires long-term prophylactic medication use and regular medical care; however, limited scientific information has been published about HAE medical care during the COVID-19 pandemic. Objective: To gather patient and health-care professional (HCP) perspectives on the global impact that COVID-19 has had, and the future impact it will have on HAE medical care and to identify differences in perceptions across economic and geographic boundaries. Methods: We conducted two independent but similar online global surveys to capture patient and HCP perspectives on the impact that COVID-19 has had, and the future impact it will have on HAE medical care. Results: Both patients and HCPs globally reported that the pandemic has limited the availability of HAE medical care, and they expect the restrictions to continue far beyond the pandemic. In addition, the results of our study suggested that telehealth use has increased across the globe but has been more successfully implemented in high-income countries. Conclusion: Patients and HCPs expect that HAE-related care will be negatively impacted by the pandemic for many years. Disparities in medical care and technologic infrastructure may exacerbate these challenges in non‐high-income countries. Supportive tools and global infrastructure should be established to provide aid to non‐high-income countries throughout the pandemic and several years after.

Reading Dalit Autobiographies in English: A Top Ten List

Dalit autobiography has joined protest poetry as a leading genre of Dalit Literature since the nineteen seventies. Finding their inspiration in the social and political activism of B. R. Ambedkar (1891-1956), leader of the India’s anti-caste movement and a founding father of the Republic, low caste men and women have documented their struggles and victories in the face of ongoing violence and deprivation. Surveying ten life narratives translated into English from Marathi, Hindi, and Kannada, the essay treats works by Ambedkar, Daya Pawar, Sharankumar Limbale, Baby Kamble, Laxman Gaikwad, Siddhalingaiah, Omprakash Valmiki, Urmila Pawar, Vasant Moon and Namdeo Nimgade. Tracing the origins of Dalit autobiography in the writings of Siddharth College and Milind College students in the 1950s, protest writers in the 1960s, and the Dalit Panthers and their followers in the 1970s, the survey identifies recurring themes of social exclusion, poverty, patriarchy, survival and assertion in the realms of politics, employment, education, and religion. These intimate testimonials share a radical vision of social transformation across caste, class, gender, linguistic and geographic boundaries and provide a needed corrective to mainstream portraits of modern Indian social history.

Changing public spheres – from Eastern European underground to international platforms

This essay explores the work of at artists from different generations who have dealt with restrained public spheres, counteracted by their work: Russian Ilya Kabakov (b. 1933), Czech Kateřina Šedá (b. 1977) and the collective digital platform Harabel in Albania. Many artists who worked within the Soviet Union were subjected to extremely deman­­ding conditions. All the same several found ways of collaborating in col­lec­tive strategies, as in the case of Ilya Kabakov, who ‘defected’ in 1989 in New York. In the west the reception of Kabakov´s art has to a large extent been reductionistic in the sense that it was initially culturally biased, tied directly to biography and nationality rather than understood as fundamentally multifaceted. Šedá’s situation is a very different one, working within a social and conceptual conception of art. She has repeatedly engaged a variety of local societies in combining city planning, daily life, politics and the private sphere in her art. In Albania a younger generation of artists has created communication networks across geographic boundaries with a main focus on digital platforms. The question the essay revolves around is the following: How does one conceive of artistic approaches to the collective in the aftermath of totalitarian systems?

Motor Neuron Diseases

The motor neuron disorders are a clinically diverse group of diseases that share a pathologic loss of the motor neurons. The most common adult-onset disorder is amyotrophic lateral sclerosis (ALS). Other forms include the spinal muscular atrophies, infectious motor neuronopathies, and rare focal forms of anterior horn cell loss.Overall, the incidence rate of ALS is believed to be 1.5 to 2.0 cases per 100,000 person-years, and the prevalence rate is 4 to 6 cases per 100,000 population. Other than in sparsely populated geographic clusters (eg, Guam and the Kii Peninsula of Japan), the incidence rate seems consistent across ethnic and geographic boundaries.

Human-Network Regions as Effective Geographic Units for Disease Mitigation

Susceptibility to infectious diseases such as COVID-19 depends on how they spread, and many studies have captured the decrease in COVID-19 spread due to reduction in travel. However, less is known about practical geographic boundaries for that limit the spread of COVID-19 to adjacent places. To detect such boundaries, we apply community-detection algorithms to large networks of mobility and social-media connections to construct geographic regions that reflect natural human movement and relationships at the county level for the continental United States. We measure COVID-19 cases, case rates, and case-rate variations across adjacent counties and examine how often COVID-19 crosses the boundaries of these functional regions. We find that regions that we construct using GPS-trace networks and especially commuter networks have the smallest rates of COVID-19 case rates along the boundaries, so these regions may reflect natural partitions in COVID-19 transmission. Conversely, regions that we construct from geolocated Facebook friendships and Twitter connections yield the least effective partitions. Our analysis reveals that regions that are derived from movement flows are more appropriate geographic units than states for making policy decisions about opening areas for activity, assessing vulnerability of populations, and allocating resources. Our insights are also relevant for policy decisions and public messaging in future emergency situations.

Where You Live Matters: Local Bank Competition, Online Marketplace Lending, and Disparity in Borrower Benefits

In the past decade, the proliferation of online marketplace lending has been disrupting the consumer credit market, especially for personal loans for debt consolidation. These lenders, for example, Lending Club, transcend the geographic boundaries within which local banks operate and offer homogeneous access and terms to borrowers. However, the ultimate benefits borrowers derive from marketplace lending can differ significantly because local alternatives may replace marketplace loans when available and favorable. Correspondingly, if local bank competition drives the substitution of an existing marketplace loan with a traditional bank loan, the promise of equal benefits to all borrowers from marketplace lending is unlikely to fully materialize. This competitive dynamic has implications for policy making, particularly in judging the ramifications of bank mergers and acquisitions (M&As). Our results indicate that a borrower who resides in a more competitive market is more likely to pay off a P2P loan early by making a large, one-time payment compared with a borrower from a less competitive market, indicating a substitution with a local bank loan. Thus, borrowers from different markets do not benefit equally from online marketplace lending, disrupting the consumer credit market. In particular, consumers in smaller markets continue to be disadvantaged because of the absence of competitive intensity. This is a consequence of traditional banks competing within their local markets and incentivized to attract marketplace borrowers to traditional loans primarily by their local market conditions. Therefore, unless geographic frictions in traditional lending markets are removed, digital disruptions cannot equalize the benefits to consumers.

CLINICORADIOLOGICAL CORRELATION OF PEDIATRIC AND NEONATAL SEIZURES

INTRODUCTION:Epilepsy is the most common serious disorder worldwide. It has no age,racial,social class,national or geographic boundaries. AIMS AND OBJECTIVES:To study imaging ndings of various pathologic conditions seen in epileptic children and neonates. MATERIALAND METHODS:Aprospective study was obtained from evaluation of 40 patients presenting with epilepsy in paediatric OPD and IPD. Head CT was obtained in 15 (37.5%), MRI in all cases. Contrast was given in patients with tumour, suspected vascular malformations, inammation, and Infectious pathology. Epilepsy provoked by causes such as fever, electrolyte imbalance and dehydration were excluded . RESULTS:The most common cause of epilepsy in our study was tuberculosis in this region, being at 22.5% which consisted cases of both tuberculoma and tubercular meningitis. This was followed shortly by neurocysticercosis at 15%. This was followed by Hypoxic Ischemic Encephalopathy at 10%. CONCLUSION:Imaging of children with epilepsy is a challenging subject and requires an understanding of the wide spectrum of pathology that affects the paediatric population

Antitrust and digital platforms in competition law: Apple Inc. v. Pepper case

Digital platforms are getting more general because of growing the level of online commerce. As a result, courts and antimonopoly regulators around the entire world face with the issues of applying antitrust rules to digital platforms. And each time it raises a number of interesting questions from the practical and theoretical point of view. In antitrust cases it’s difficult to define the product and geographic boundaries of the market where digital platforms operate. In 2019 the US Supreme Court decide a case between a group of iPhone users and Apple Inc. iPhone users filed a lawsuit against Apple Inc. claiming that Apple had unlawfully monopolized market for the sale of apps by charging consumers higher than competitive prices. US Supreme Court’s judgment in Apple v Pepper is really crucial for competition law, indeed. During analyzing the case, the following questions arise. Whether the «App Store» is a digital platform or not? Whether the «App Store» is a product market or not? If the «App Store» is a product market, what way should we determine geographic boundaries of this market? However, US Supreme Court’s judgment in Apple v Pepper does not provide us with answers to these questions. Obviously, the court had good reasons for this. Let's analyze this judgment and try to find answers to the questions that the US Supreme Court left opened.

Classical Koro and Koro-Like Symptoms: Illustration from Canada

Koro syndrome has been colorfully described as a pathological distortion of one’s body image of the genital organ. In Koro, body image dysphoria is characterized by severe anxiety related to the delusional idea that one’s genitals will shrink and retract into one’s abdomen, eventually leading to death. This syndrome was first reported in South East Asia, where endemics have been described, but it has also sporadically occurred globally. We present a systematic literature review on Koro syndrome and report 7 cases from Canada. A search review with PubMed and Google Scholar resulted in 504 entries. Sixty-seven manuscripts were eventually selected following a thorough elimination process. The resultant literature underscored the cultural diversity that underlay the reported cases. Various aspects of Koro have been examined (eg, etiological, clinical, diagnostic, and cultural aspects). It has stimulated substantial scholarly debate, discussions, correspondences, and arguments from anthropological, psychiatric, psychological, and biological perspectives. In our series, it seems that Koro could have been misattributed here. The primary concern was not with penile retraction of the cases. To our knowledge, this is the first time that a series of cases is documented from North America where the syndrome is often ignored. We highlight the potential differences between the classical Koro syndrome and a collection of beliefs related to the perception or delusion of penile retraction in other codable psychiatric disorders, Koro-like syndrome. Understanding Koro syndrome beyond geographic boundaries is in line with our collected case reports of Koro from outside Asia.

Integrating Positive Youth Development: Insights From International Youth Development Programming

Effective international youth development programs go beyond single-issue interventions—they leverage the entire organization and project life cycle to advance positive youth outcomes. This paper illustrates how positive youth development (PYD) approaches can be adapted for and applied by organizations to promote positive outcomes for young people and communities globally. The article provides 6 insights from the International Youth Foundation’s (IYF) application of PYD principles across diverse youth development programs. Moreover, the authors present practical insights into what is required by practitioners, regardless of geographic boundaries, to effectively engage with, support, and meet the needs of youth and young adults whom they serve. Finally, the article argues that practitioners and funders need to find new ways to measure and value PYD investments and that funders need to make PYD integral across their funding streams.