Spectrophotometric Method for Determination of Meclizine in Pure and Dosage form Via Ion Pair Complex Formation Using Eosin Y

A simple and sensitive spectrophotometric method has been developed for the determination of cetirizine (I), ebastine (II), fexofenadine (III), ketotifen (IV), and loratadine (V) based on ion-pair complex formation with erythrosine B. The pink color of the produced complex was measured at 550 nm without solvent extraction. Appropriate conditions were established by studying the color reaction between erythrosine B and the studied drugs to obtain the maximum sensitivity. Beer-Lambert's law is obeyed in the concentration ranges 1–7, 1–8, and 1–6 g/mL for (I, IV), (II, III), and (V), respectively. The method was validated according to ICH guidelines. The suggested method is applicable for the determination of the five investigated drugs in bulk and pharmaceutical dosage forms with excellent recoveries.

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Spectrophotometric Determination of Ciprofloxacin by Ion-pair complex Formation with Bromothymol Blue

journal of the college of basic education ◽

10.35950/cbej.v17i72.4501 ◽

2019 ◽

Vol 17 (72) ◽

pp. 93-100

Author(s):

Kawther A. Sadeq

Keyword(s):

Complex Formation ◽

Spectrophotometric Determination ◽

Spectrophotometric Method ◽

Bromothymol Blue ◽

Ion Pair ◽

Tablet Formulation ◽

Pure Form

A new simple spectrophotometric method based on the formation of an ion –pair using bromothymol blue as ion –pair complexion reagent was developed for the determination of ciprofloxacin in pure form and tablets . Theion-pair formed was highly colored and easily extracted with chloroform at (pH3.0) and determined spectrophotometrically at 421 nm .The proposed method was successfully applied to determine (CPF) in its tablet formulation and the results are good , No interferences from an effective addition were noticed .

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Extractive Spectrophotometric Method for the Determination of Glibenclamide by Ion-Pair Complex in Pure Form and Pharmaceutical Formulation

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v9i3.20 ◽

2019 ◽

Vol 9 (o3) ◽

Author(s):

RUAA MUAYAD MAHMOOD ◽

HAMSA MUNAM YASSEN ◽

SAMAR , NAJWA ISSAC ABDULLA AHMED DARWEESH ◽

NAJWA ISSAC ABDULLA

Keyword(s):

Spectrophotometric Method ◽

Molar Absorptivity ◽

Ion Pair ◽

Pharmaceutical Formulation ◽

Ratio Method ◽

Colored Complex ◽

Colored Product ◽

Method Of Continuous Variation ◽

Job's Method

Simple, rapid and sensitive extractive spectrophotometric method is presented for the determination of glibenclamide (Glb) based on the formation of ion-pair complex between the Glb and anionic dye, methyl orange (MO) at pH 4. The yellow colored complex formed was quantitatively extracted into dichloromethane and measured at 426 nm. The colored product obeyed Beer’s law in the concentration range of (0.5-40) μg.ml-1. The value of molar absorptivity obtained from Beer’s data was found to be 31122 L.mol-1.cm-1, Sandell’s sensitivity value was calculated to be 0.0159 μg.cm-2, while the limits of detection (LOD) and quantification (LOQ) were found to be 0.1086 and 0.3292 μg.ml-1, respectively. The stoichiometry of the complex created between the Glb and MO was 1:1 as determined via Job’s method of continuous variation and mole ratio method. The method was successfully applied for the analysis of pharmaceutical formulation.

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