Macrophage Migration Inhibitory Factor: A Therapeutic Target Across Inflammatory Diseases

2007 ◽  
Vol 6 (3) ◽  
pp. 183-190 ◽  
Author(s):  
Alberta Hoi ◽  
Magdy Iskander ◽  
Eric Morand
Keyword(s):  
Migration Inhibitory Factor ◽  
Therapeutic Target ◽  
Macrophage Migration Inhibitory Factor ◽  
Inflammatory Diseases ◽  
Inhibitory Factor ◽  
Macrophage Migration

scholarly journals Role of Macrophage Migration Inhibitory Factor in Hepatitis B Virus-Specific Cytotoxic-T-Lymphocyte-Induced Liver Injury

2006 ◽  
Vol 13 (3) ◽  
pp. 415-419 ◽  
Author(s):  
Kiminori Kimura ◽  
Masahito Nagaki ◽  
Jun Nishihira ◽  
Shinichi Satake ◽  
Kazuo Kuwata ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Liver Injury ◽  
Hepatitis B ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inflammatory Diseases ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Antibody Treatment ◽  
B Virus

ABSTRACT Macrophage migration inhibitory factor (MIF) plays a pivotal role in the development of various inflammatory diseases. Here, we found that anti-mouse MIF antibody treatment reduced liver injury and inflammatory cell infiltration into the liver after injection of antigen-specific cytotoxic T lymphocytes into hepatitis B virus transgenic mice.

scholarly journals Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer

BMC Cancer ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Tejaswini Subbannayya ◽  
Pamela Leal-Rojas ◽  
Mustafa A. Barbhuiya ◽  
Remya Raja ◽  
Santosh Renuse ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Migration Inhibitory Factor ◽  
Therapeutic Target ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Macrophage Migration

scholarly journals Macrophage migration inhibitory factor: molecular, cellular and genetic aspects of a key neuroendocrine molecule

2004 ◽  
Vol 182 (1) ◽  
pp. 1-9 ◽  
Author(s):  
RP Donn ◽  
DW Ray
Keyword(s):  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inflammatory Diseases ◽  
Inhibitory Factor ◽  
Target Cells ◽  
Macrophage Migration ◽  
Signalling Molecules ◽  
Functional Polymorphisms ◽  
Low Concentrations

The immunological and neuroendocrine properties of macrophage migration inhibitory factor (MIF) are diverse. In this article we review the known cellular, molecular and genetic properties of MIF that place it as a key regulatory cytokine, acting within both the innate and adaptive immune responses.The unexpected and paradoxical induction of MIF secretion by low concentrations of glucocorticoids is explored. The role of MIF as a locally acting modulator of glucocorticoid sensitivity within foci of inflammation is also discussed. MIF has no homology with any other pro-inflammatory cytokine and until recently lacked a recognised transmembrane receptor. MIF has also been shown to be directly taken up into target cells and to interact with intracellular signalling molecules, including the Jun activation domain-binding protein Jab-1.Comprehensive analysis of the MIF gene has identified important functional polymorphisms and a series of genetic studies has revealed both association and linkage of MIF with inflammatory diseases. Altered MIF regulation may therefore be pivotal to acquiring chronic inflammation following an innate immune response.

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