Trench Fever: A Bartonella Quintana Infection

2020 ◽  
pp. 171-175
Author(s):  
Muhammad Imran Qadir ◽  
Basra Manzoor
2003 ◽  
Vol 47 (2) ◽  
pp. 614-619 ◽  
Author(s):  
Jean-Marc Rolain ◽  
Max Maurin ◽  
Marie-Noëlle Mallet ◽  
Daniel Parzy ◽  
Didier Raoult

ABSTRACT Bartonella quintana, the agent of trench fever, has recently been implicated in various diseases, in particular, bacteremia and endocarditis in homeless people. The host cell of Bartonella spp. is believed to be the erythrocyte, and in the present study we demonstrate that B. quintana can be cultured in vitro in human erythrocytes. The bacteria were found to be intraerythrocytic by laser confocal microscopy with Bartonella species-specific monoclonal antibodies. Infections with B. quintana decreased the life span of erythrocytes in culture from 8.6 to 4.8 days. In the culture system we found that most of the antibiotics that we tested (doxycycline, fluoroquinolone compounds, and beta-lactams) were not bactericidal. Gentamicin was bactericidal at 4 μg/ml, as was rifampin, but to a lesser extent. At this concentration, gentamicin has been shown to enter erythrocytes slowly and to reach a peak level of 0.26 μg/ml after 24 h. At 0.26 μg/ml, however, we found that gentamicin was not able to kill extracellular B. quintana, even after 96 h of incubation. We hypothesize that erythrocytes may be a reservoir for B. quintana and that the bactericidal activity of gentamicin that we observed occurs mainly when the bacteria emerge from the erythrocytes and are found extracellularly. It would appear that gentamicin should be administered for at least 5 days to cure patients infected with B. quintana.


2015 ◽  
Vol 9 (6) ◽  
pp. e0003871 ◽  
Author(s):  
Hamza Leulmi ◽  
Idir Bitam ◽  
Jean Michel Berenger ◽  
Hubert Lepidi ◽  
Jean Marc Rolain ◽  
...  

2008 ◽  
Vol 59 (2) ◽  
pp. 103
Author(s):  
M. Kobayashi ◽  
N. Seki ◽  
S. Kasai ◽  
K. Tanaka ◽  
O. Komagata ◽  
...  

2000 ◽  
Vol 31 (1) ◽  
pp. 131-135 ◽  
Author(s):  
M. E. Ohl ◽  
D. H. Spach

2020 ◽  
Vol 192 (49) ◽  
pp. E1723-E1726
Author(s):  
Carl Boodman ◽  
Terence Wuerz ◽  
Philippe Lagacé-Wiens

2015 ◽  
Vol 9 (5) ◽  
pp. e0003789 ◽  
Author(s):  
Hamza Leulmi ◽  
Idir Bitam ◽  
Jean Michel Berenger ◽  
Hubert Lepidi ◽  
Jean Marc Rolain ◽  
...  

Author(s):  
Ba-Hoang-Anh Mai ◽  
Rémi Barbieri ◽  
Thomas Chenal ◽  
Dominique Castex ◽  
Richard Jonvel ◽  
...  

ABSTRACTBartonella quintana caused trench fever in the framework of two World Wars and is now recognized as an agent of re-emerging infection. Many reports indicated the popularity of B. quintana exposure since the 90s. For evaluating its prevalence in ancient populations, we used real-time PCR to detect B. quintana DNA in 400 teeth collected from 145 individuals dating from the 1st to 19th centuries in nine archeological sites with the presence of negative controls. Fisher’s exact test was used to compare the prevalence of B. quintana detection in civil and military populations. B. quintana DNA was confirmed in a total of 28/145 (19.3%) individuals, comprising 78 citizens and 67 soldiers, 20.1% and 17.9% of which were positive for B. quintana bacteremia, respectively. This study collected previous studies on these ancient samples and showed that the presence of B. quintana infection followed the course of time in human history; a total of 14/15 sites from five European countries had a positive prevalence. The positive rate in soldiers was higher than those of citizens, with 20% and 18.8%, respectively, in the 18th - 19th centuries, but the difference in frequency was not significant. These results confirmed the role of dental pulp in diagnosing B. quintana bacteremia in ancient populations and showed the incidence of B. quintana in both citizens and soldiers. Many recent findings contributed to understanding the coevolution of the relationship between B. quintana and humans.


2003 ◽  
Author(s):  
Charles Thomas Parker ◽  
Dorothea Taylor ◽  
George M Garrity
Keyword(s):  

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