Plastic Embedding of Arabidopsis Stem Sections

The use of a plastic embedding technique has been described and its relevance in orthodontic teaching and clinical practice discussed. We have found that many aspects of orthodontic instruction benefit from the use of these materials.

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Introduction to Currently Applied Device Pathology

Toxicologic Pathology ◽

10.1177/0192623319826585 ◽

2019 ◽

Vol 47 (3) ◽

pp. 221-234 ◽

Cited By ~ 5

Author(s):

Molly C. Friedemann ◽

Nicole A. Mehta ◽

Staci L. Jessen ◽

Fatima H. Charara ◽

Anne-Marie Ginn-Hedman ◽

...

Keyword(s):

Medical Device ◽

Complex Nature ◽

Safety And Efficacy ◽

Pathologic Evaluation ◽

Microscopic Evaluation ◽

Plastic Embedding ◽

Medical Device Safety ◽

Efficacy Assessment ◽

Pathologic Analysis ◽

Implanted Devices

Pathologic evaluation is crucial to the study of medical devices and integral to the Food and Drug Administration and other regulatory entities’ assessment of device safety and efficacy. While pathologic analysis is tailored to the type of device, it generally involves at a minimum gross and microscopic evaluation of the medical device and associated tissues. Due to the complex nature of some implanted devices and specific questions posed by sponsors, pathologic evaluation inherently presents many challenges in accurately assessing medical device safety and efficacy. This laboratory’s experience in numerous collaborative projects involving veterinary pathologists, biomedical engineers, physicians, and other scientists has led to a set of interrelated assessments to determine pathologic end points as a means to address these challenges and achieve study outcomes. Thorough device evaluation is often accomplished by utilizing traditional paraffin histology, plastic embedding and microground sections, and advanced imaging modalities. Combining these advanced techniques provides an integrative, comprehensive approach to medical device pathology and enhances medical device safety and efficacy assessment.

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Microwave Mechanisms — The Energy/Heat Dichoto

Microscopy Today ◽

10.1017/s1551929500051944 ◽

2004 ◽

Vol 12 (2) ◽

pp. 18-23 ◽

Cited By ~ 8

Author(s):

Jose J. Galvez ◽

Richard T. Giberson ◽

Robert D. Cardiff

Keyword(s):

Biological Sciences ◽

Microwave Energy ◽

Microwave Oven ◽

Chemical Processes ◽

Antigen Retrieval ◽

Microwave Technology ◽

Plastic Embedding ◽

Speed Up ◽

Histological Staining

The current use of microwave technology in science creates a dichotomy. Is it the heat or is it the energy? One entire branch of science, chemistry, uses microwave energy to apply heat to a broad range of chemical processes, under pressure, to produce the desired end-products quickly and efficiently (1). The biological sciences, surgical pathology in particular, have tried to adapt the microwave oven to speed up a broad range of processes: fixation, decalcification, antigen retrieval, tissue processing for paraffin and plastic embedding, and histological staining, including special stains, immunolabeling, and in situ hybridization (2). The biologists have assumed that they are also applying heat to speed processing. However, recent improvements in the microwave suggest that the energy is the critical variable (9). We have designed fixation experiments to test the two views.

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