scholarly journals Uterine Artery Embolization Versus Hysterectomy in the Treatment of Symptomatic Adenomyosis: Protocol for the Randomized QUESTA Trial (Preprint)

2017 ◽  
Author(s):  
Annefleur Machteld de Bruijn ◽  
Paul NM Lohle ◽  
Judith AF Huirne ◽  
Jolanda de Vries ◽  
Moniek Twisk ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Uterine Artery Embolization ◽  
Uterine Artery ◽  
Transvaginal Ultrasound ◽  
Uterine Disease ◽  
Artery Embolization ◽  
Randomized Controlled ◽  
The Impact

BACKGROUND Adenomyosis is a benign uterine disease characterized by invasion of endometrium into the myometrium resulting in heavy menstrual bleeding and pain (dysmenorrhea). Hysterectomy is established as the final treatment option when conservative treatment fails. Uterine artery embolization (UAE) in patients with symptomatic adenomyosis has demonstrated to reduce symptoms and improve quality of life. However, randomized controlled trials are lacking. OBJECTIVE With this study, we aim to evaluate the impact of UAE on Health-Related Quality of Life (HRQOL) in a randomized comparison to hysterectomy in patients with symptomatic adenomyosis. METHODS This is a multicenter non-blinded randomized controlled trial comparing UAE and hysterectomy. Eligible patients are symptomatic premenopausal women without the desire to conceive and who have symptomatic magnetic resonance imaging (MRI)–confirmed pure adenomyosis or dominant adenomyosis accompanied by fibroids. After obtaining informed consent, patients will be randomly allocated to treatment in a 2:1 UAE versus hysterectomy ratio. The primary objective is HRQOL at 6 months following the assigned intervention. Secondary outcomes are technical results, pain management, clinical outcomes, HRQOL, and cost effectiveness during 2 years of follow-up. In addition, transvaginal ultrasound (TVUS) and MRI will be performed at regular intervals after UAE. RESULTS Patient enrollment started November 2015. The follow-up period will be completed two years after inclusion of the last patient. At the time of submission of this article, data cleaning and analyses have not yet started. CONCLUSIONS This trial will provide insight for caretakers and future patients about the effect of UAE compared to the gold standard hysterectomy in the treatment of symptomatic adenomyosis and is therefore expected to improve patients’ wellbeing and quality of life. CLINICALTRIAL Netherlands Trial Register NTR5615; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=5615 (Archived by WebCite at http://www.webcitation.org/6xZRyXeIF)

scholarly journals Myoma of the uterus: the organ-preservation treatment (a review)

2020 ◽  
Vol 20 (1-2) ◽  
pp. 13-18
Author(s):  
Elmira T. Nurmukhametova
Keyword(s):  
Quality Of Life ◽  
Organ Preservation ◽  
Uterine Artery Embolization ◽  
Uterine Artery ◽  
Web Of Science ◽  
Uterine Fibroids ◽  
Artery Embolization ◽  
Radical Method ◽  
Methods Of Treatment

Uterine fibroids are one of the main causes of hysterectomy. This radical method of treatment allows to control such symptoms as pain and bleeding, but significantly worsens womens quality of life, preventing them from their childbearing function. This article includes the results of domestic and foreign studies on organ-preserving methods of treatment of uterine fibroids published within 10 years. The method of uterine artery embolization, which is preferred by an increasing number of doctors and patients suffering from fibroids, is also described in the article. The search for articles was carried out in the databases Pubmed, Web of Science, Scopus.

scholarly journals Uterine artery embolization for symptomatic fibroids: long-term changes in disease-specific symptoms and quality of life

2011 ◽  
Vol 26 (8) ◽  
pp. 2036-2042 ◽  
Author(s):  
C. Scheurig-Muenkler ◽  
A. Lembcke ◽  
V. Froeling ◽  
M. Maurer ◽  
B. Hamm ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Uterine Artery Embolization ◽  
Uterine Artery ◽  
Artery Embolization ◽  
Long Term Changes ◽  
Specific Symptoms ◽  
Disease Specific

scholarly journals Uterine artery embolization improves quality of life in patients with pure adenomyosis: A single-center experience

2020 ◽  
Vol 4 (2) ◽  
pp. 117
Author(s):  
Ibrahim Alrashidi ◽  
Hayat Alharthy ◽  
Faisal Alahmari ◽  
Sultan Alammari ◽  
Hatim Alobaidi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Uterine Artery Embolization ◽  
Uterine Artery ◽  
Single Center ◽  
Artery Embolization ◽  
Single Center Experience

Uterine artery embolization for leiomyomata – symptoms control and quality of life

2018 ◽  
Vol 4 (22) ◽  
pp. 22
Author(s):  
Cătălin George Nenciu ◽  
Mihai Dumitraşcu ◽  
Adina-Elena Nenciu
Keyword(s):  
Quality Of Life ◽  
Uterine Artery Embolization ◽  
Uterine Artery ◽  
Artery Embolization

scholarly journals Arterial Embolization in Large Uterine Fibroids : A 4-Year Single Center Experience

2019 ◽  
Vol 7 (10) ◽  
Author(s):  
Volkan Çakır ◽  
Ömür Ballı
Keyword(s):  
Tumor Size ◽  
Uterine Artery Embolization ◽  
Uterine Artery ◽  
Current Knowledge ◽  
Case Reports ◽  
Uterine Fibroids ◽  
Artery Embolization ◽  
Pelvic Mri ◽  
The Impact

Purpose: Current knowledge concerning the use of uterine artery embolization (UAE) in large uterine fibroids is limited with the majority of studies being limited to case reports. The present retrospective study aimed to investigate the impact of UAE on symptoms and tumor size in symptomatic women with at least one large uterine fibroid. Methods: 39 patients undergoing UAE for symptomatic large uterine fibroids (>5cm) were consecutively enrolled in this study. All patients underwent a detailed physical examination and contrast-enhanced pelvic MRI at 3, 6 and 12 months after the procedure. Results: Compared to baseline values (7.8 ± 2.4 cm), the mean diameter of the fibroids significantly reduced at 3rd (5.5 ± 1.7 cm), 6th (4.2 ± 1.3 cm) and 12th (3.1 ± 0.6 cm) months follow-up (p<0.005 for each compared to baseline) implying a 60 % reduction in tumor size at 12 months compared to baseline measurements. At the end of the 12 months follow-up, complete necrosis of the fibroid was achieved in 88%, complete symptom resolution was achieved in 92%, and >50 % reduction in fibroid diameter was acquired in 87 % of the participants. Conclusion: Uterine artery embolization provides 60 % reduction in fibroid volume and a 92 % improvement in fibroid-related symptoms in patients with large fibroids at the end of 12 months follow-up.

scholarly journals Role of Uterine Artery Embolization using Embolic Microspheres in Treatment of Uterine Fibroid

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
R H Bassiouny ◽  
A M S Elshimy ◽  
B S Tawfik
Keyword(s):  
Quality Of Life ◽  
Minimally Invasive ◽  
Uterine Artery Embolization ◽  
Uterine Artery ◽  
Invasive Procedure ◽  
Baseline Score ◽  
Minimally Invasive Procedure ◽  
Artery Embolization ◽  
The Mean

Abstract Background Uterine Artery Embolization (UAE) is a well-established treatment of symptomatic fibroids with clinical efficacy comparable with traditional surgical treatment. UAE is now commonly proposed as an organ preserving treatment to the population of younger women willing to conceive. It has been proven, in a large cohort of women wishing to conceive before embolization, that complete pregnancies can occur after UAE Objectives The study aims to assess the effect of uterine artery embolization using the different types of embolic microspheres in treatment of patients with uterine fibroid. Patients and Methods Type of Study: prospective study. Study Setting: At the radiology department of Ain Shams University hospitals and Ain Shams University Specialized Hospitals. Study Period: 6-12 months. Results High symptom severity score indicates severe symptoms and a high HRQOL score indicates a good quality of life. The mean UFS questionnaire baseline score was 70± 11.51 prior to embolization and became 45± 9.34 three months following embolization which indicates a good symptomatic response to the microspheres embolization. The mean QOL baseline score was 65± 8.58 prior to embolization and 81± 6.48 three months following embolization. Conclusion UAE using embolic microsphere is , an effective, minimally invasive procedure and easily one day procedure which showed competitive promising and well proved results when compared to other modalities outcomes in treating uterine fibroids such as conventional surgery. It deserves our attention to it's value and efficacy for the sake of the patient as a minimally invasive procedure providing better quality of life , using Embosphere and Embozene microspheres have the same symptomatic effect and volume reduction after three months follow up in compare with using Embosphere alone or with spherical polyvinyl alcohol particles.

Patient satisfaction and disease specific quality of life after uterine artery embolization

2004 ◽  
Vol 190 (6) ◽  
pp. 1697-1703 ◽  
Author(s):  
Wendy J Smith ◽  
Elizabeth Upton ◽  
Elizabeth J Shuster ◽  
Arnold J Klein ◽  
Martin L Schwartz
Keyword(s):  
Quality Of Life ◽  
Patient Satisfaction ◽  
Uterine Artery Embolization ◽  
Uterine Artery ◽  
Artery Embolization ◽  
Disease Specific
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