scholarly journals Drug Therapy for Pain Diseases:Selection of Analgesics Based on “Second Edition of Guidelines for the Pharmacologic Management of Neuropathic Pain”

2018 ◽  
Vol 38 (4) ◽  
pp. 465-473
Author(s):  
Shinsuke HAMAGUCHI
Author(s):  
Sachin Rastogi ◽  
Fiona Campbell

Neuropathic pain is defined as “pain arising as a direct consequence of a lesion or disease affecting the somatosensory system.” It is often contrasted with nociceptive pain, which is associated with tissue injury or inflammation. Neuropathic pain conditions in children are qualitatively different from those common in adults and include complex regional pain syndrome, postoperative neuropathic pain, and autoimmune and degenerative neuropathies. Few randomized controlled trials in pediatrics means that evidence from adult studies is extrapolated to guide pharmacological management in children, which is problematic as the etiologies and mechanisms are different. An algorithm for drug therapy is proposed based on the best-available evidence, clinical experience, and the safety of these drugs in pediatric practice. A step-wise approach should be tried methodically according to effectiveness and side effects. Neuropathic pain in children, if identified and treated in a timely manner as part of an interprofessional framework, can be managed effectively.


2020 ◽  
Vol 24 (9) ◽  
Author(s):  
Mariam Salisu Orhurhu ◽  
Robert Chu ◽  
Lauren Claus ◽  
Jacob Roberts ◽  
Bisi Salisu ◽  
...  

2022 ◽  
Vol 34 (1) ◽  
pp. 61-81
Author(s):  
Yoav Nudell ◽  
Harry Dym ◽  
Feiyi Sun ◽  
Michael Benichou ◽  
Jonathan Malakan ◽  
...  

2019 ◽  
pp. 105-112
Author(s):  
Sebastian Rubino ◽  
Shelby Sabourin ◽  
Julie G. Pilitsis

Vertebral metastases often lead to a complex pain syndrome that consists of both nociceptive and neuropathic pain. Multimodal medical management often includes paracetamol, non-steroidal anti-inflammatory agents, bisphosphonates, opioids, antidepressants, anti-epileptics, and neuroleptics. Surgical treatment to address oncologic burden and spinal instability, radiation therapy, and vertebroplasty or kyphoplasty may be indicated for some patients. However, often times patients with advanced malignancies are not able to safely undergo surgery and have medication-refractory oncologic pain. For these patients and for patients unwilling to undergo large oncologic or spinal stabilization surgeries, intrathecal drug therapy (IDT) serves as a safe and effective adjunct in the management of cancer-related pain.


Revista Dor ◽  
2016 ◽  
Vol 17 ◽  
Author(s):  
Durval Campos Kraychete ◽  
Mariana Camargo Palladini ◽  
Anita Perpétua Carvalho Rocha Castro

Pain ◽  
2007 ◽  
Vol 132 (3) ◽  
pp. 237-251 ◽  
Author(s):  
Robert H. Dworkin ◽  
Alec B. O’Connor ◽  
Miroslav Backonja ◽  
John T. Farrar ◽  
Nanna B. Finnerup ◽  
...  

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