HUMAN ORGANIC SOLUTE TRANSPORTERS UTTERED IN SMALL INTESTINE, LIVER, AND KIDNEY FOR HOMEOSTASIS

The transporters participate in a significant role in drug absorption, distribution, metabolism, and elimination. Transporters are of efflux and influx type, need ATP-binding sites for their in and out movement across the cell membrane. These transporters play an important role in allowing or opposing the drugs into the cells, results in non-linearity in drug pharmacokinetics. A wide range of transporters was discovered; among them, organic solute transporters (OST) play a key role in drug absorption and disposition. Organic solute transporters is a heteromeric transporter localized to the basolateral of epithelial cells. It is the primary efflux bile acid transporter in the intestine of mammals.

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Effect of Bile Acids and Other Factors on Cholesterol Uptake by Inverted Intestinal Sacs

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1958.195.3.773 ◽

1958 ◽

Vol 195 (3) ◽

pp. 773-778 ◽

Cited By ~ 6

Author(s):

Archie L. Smith ◽

C. R. Treadwell

Keyword(s):

Small Intestine ◽

Bile Acid ◽

Bile Acids ◽

Binding Sites ◽

Cellular Protein ◽

Rat Small Intestine ◽

Cholesterol Uptake ◽

Quantitative Studies ◽

Mucosal Cells ◽

Intestinal Mucosal Cells

Conditions for the use of inverted sacs of rat small intestine for quantitative studies of cholesterol uptake are described. The uptake of cholesterol by sacs did not require glucose in the incubation medium. Albumin aided cholesterol uptake but was not obligatory for this process. A binding of cholesterol to a cellular protein is proposed as the mechanism for the entrance of cholesterol into intestinal mucosal cells. Both conjugated and unconjugated bile acids inhibited cholesterol uptake possibly by blocking the binding sites of the protein responsible for cholesterol uptake. Commercial taurocholate and glycocholate contain an inhibitor of cholesterol uptake other than the bile acid.

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Elimination of Na + -dependent bile acid transporter from small intestine by ileum resection increase colonic tumorigenesis in the rat fed deoxycholic acid

Cancer Letters ◽

10.1016/s0304-3835(99)00240-2 ◽

1999 ◽

Vol 145 (1-2) ◽

pp. 115-120 ◽

Cited By ~ 15

Author(s):

Ryuhei Kanamoto ◽

Naoyuki Azuma ◽

Hitoshi Suda ◽

Thoru Seki ◽

Yasunari Tsuchihashi ◽

...

Keyword(s):

Small Intestine ◽

Bile Acid ◽

Deoxycholic Acid ◽

Bile Acid Transporter ◽

Acid Transporter

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Antibacterial Drug Treatment Increases Intestinal Bile Acid Absorption via Elevated Levels of Ileal Apical Sodium-Dependent Bile Acid Transporter but Not Organic Solute Transporter α Protein

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.b14-00640 ◽

2015 ◽

Vol 38 (3) ◽

pp. 493-496 ◽

Cited By ~ 5

Author(s):

Masaaki Miyata ◽

Kenjiro Hayashi ◽

Hiroki Yamakawa ◽

Yasushi Yamazoe ◽

Kouichi Yoshinari

Keyword(s):

Bile Acid ◽

Drug Treatment ◽

Antibacterial Drug ◽

Acid Absorption ◽

Bile Acid Absorption ◽

Organic Solute Transporter ◽

Sodium Dependent ◽

Bile Acid Transporter ◽

Organic Solute ◽

Solute Transporter

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Ileal Bile Acid-binding Protein, Functionally Associated with the Farnesoid X Receptor or the Ileal Bile Acid Transporter, Regulates Bile Acid Activity in the Small Intestine

Journal of Biological Chemistry ◽

10.1074/jbc.m507454200 ◽

2005 ◽

Vol 280 (51) ◽

pp. 42283-42289 ◽

Cited By ~ 56

Author(s):

Mayuko Nakahara ◽

Norihiko Furuya ◽

Kentaro Takagaki ◽

Takeshi Sugaya ◽

Keiko Hirota ◽

...

Keyword(s):

Small Intestine ◽

Bile Acid ◽

Binding Protein ◽

Farnesoid X Receptor ◽

Acid Binding Protein ◽

Bile Acid Transporter ◽

Bile Acid Binding ◽

Acid Transporter

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224 Organic Solute Transporter alpha-beta (Osta-Ostβ) Protects Small Intestine from Potential Bile Acid-Induced Injury

Gastroenterology ◽

10.1016/s0016-5085(16)33454-0 ◽

2016 ◽

Vol 150 (4) ◽

pp. S1020

Author(s):

Courtney B. Ferrebee ◽

Anuradha Rao ◽

Jamie Haywood ◽

Kim Pachura ◽

Paul A. Dawson

Keyword(s):

Small Intestine ◽

Bile Acid ◽

Organic Solute Transporter ◽

Organic Solute ◽

Alpha Beta ◽

Solute Transporter

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Increased expression of ileal apical sodium-dependent bile acid transporter in postpartum rats

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.00309.2001 ◽

2002 ◽

Vol 282 (1) ◽

pp. G41-G50 ◽

Cited By ~ 15

Author(s):

Aldo D. Mottino ◽

Tim Hoffman ◽

Paul A. Dawson ◽

Marcelo G. Luquita ◽

Juan A. Monti ◽

...

Keyword(s):

Small Intestine ◽

Bile Acid ◽

Membrane Vesicles ◽

Proximal Region ◽

Unit Weight ◽

Intestinal Loop ◽

Loop Model ◽

Sodium Dependent ◽

Bile Acid Transporter ◽

Acid Transporter

The expression and activity of the apical ileal sodium-dependent bile acid transporter (asbt) was examined in the small intestine of control, pregnant, and lactating postpartum rats 2, 12, and 21 days after delivery. Western blot analysis of brush border membrane vesicles (BBMV) prepared from different regions of the small intestine demonstrated that expression of asbt was maximal in the most distal segments for all experimental groups, was not substantially affected in pregnant and 2-day postpartum rats, and was significantly increased in 12- and 21-day postpartum rats. Analysis of mRNA suggested that asbt protein was regulated at the posttranscriptional level in postpartum rats. Increased expression of asbt protein postpartum was maximal (∼2-fold) in the proximal region of the ileum, consistent with a 60% increase in taurocholate (TC) transport in BBMV from the proximal ileum in 14- to 21-day postpartum rats relative to control rats. Absorption of TC, determined from the intact proximal ileum using an intestinal loop model, demonstrated a 30% increase in TC uptake per unit weight of tissue in 14- to 21-day postpartum rats relative to control rats. Together with the marked increase in intestinal mass observed at peak lactation, these data indicate a significant increase in asbt-mediated reclamation of bile acids in the intestine of lactating rats.

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